DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and trhde.2

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	925	Identity:	269/925 - (29%)
Similarity:	441/925 - (47%)	Gaps:	74/925 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILS 69
            ||    .||.||        :.|||.||:|.|...:|    :.:|||||.|.......|:.|:|.
Zfish   104 PW----RHLRLP--------ATLRPRHYDLRLTVHME----NFSFSGEVNIEFECVNSTKLIVLH 152

  Fly    70 NNGLQVGENVLLVRRNTGG--RVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RA 131
            ::.|::.:.::.......|  |:..|..:|...|:.:.: ...|..| ..|.:.:.|:..:. ..
Zfish   153 SDRLELDKVLVFSDSKKAGAMRIQRRFHYQPKQVYVIAL-HREMKPL-RTYKINITFTAHIEHEL 215

  Fly   132 SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKT 196
            .|:|...||.:... :::||||.:|..|...||||:...:.|.|.::|.|.....::|||.|..|
Zfish   216 LGFFRSSYMLNGER-RFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEAT 279

  Fly   197 SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKI--ADQGDYAISI 259
            :..| |.:|...|.:||.||...||:::..||.: .|....|..:..:.||..  :..||||:.|
Zfish   280 TSDE-DGWVTNHFSRTPRMSTYYLAWAVCNFTYK-EAVADNGVLIRLYARPDAIQSGSGDYALRI 342

  Fly   260 TPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASH 324
            |.:::.|:...|...|...|:|.|.:|...|.:.|:.||..:.|...|.....|:...:.::...
Zfish   343 TKRLLQFYQDYFKVKYSLPKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMV 407

  Fly   325 VAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQAL-AVLVEDSK 385
            |..|..|.|..||.....:   ||..|.:.|......|.:.|.|...:...:...| .|::.|..
Zfish   408 VVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGL 472

  Fly   386 SSAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAF 445
            :|::|:|......:.     |..|.:|.|.|.|||.:::|...|..||..||. :|...::.:..
Zfish   473 ASSHPISQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLM-THMYGNAARDD 536

  Fly   446 LWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDT--NEVTVTQERF-------L 501
            ||:.|.|....:   .:||.::|:||.||:|.|||::.:.:| |:  |.:|::||.|       :
Zfish   537 LWNKLSEAMQRE---GKDINITQVMDRWTLQMGYPVVTISKN-DSLDNSITISQEHFVYDTDAKI 597

  Fly   502 RNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLR 566
            :|| :|..|..| |.:|||.| .|..|.:||....|:|.:........::.|.     |::.|:.
Zfish   598 QNP-ELFNKSFQ-WQIPLTLA-VGNASHISTETIIWVTNKSEAHRVGHVVGET-----WLLGNIN 654

  Fly   567 LATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNE 631
            .....|:.||..||:|:...|: .|.:.|....||.||.||.|||.||.:..::.|..:.:|..|
Zfish   655 QTGYFRVNYDLHNWKLLIQQLT-RNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQE 718

  Fly   632 DEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDEL----FKRDGSAAENANIT-EL 691
            .||:.|.||...|..|.:.|.:|...|.|..::...::.|:.:|    ...|||...:|..| ||
Zfish   719 TEFLPWHAASRALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSLMHSAYQTEEL 783

  Fly   692 MVIVLQLSCRTDLESCADFALKEFAG-LTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTR 755
            ...|:.|:|....:.|...|:...:. ::...||||.::.:.:|||.:....|..|..:...:..
Zfish   784 QREVIMLACSFGNKHCHRQAVSLISDWISSNKNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHS 848

  Fly   756 SNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDN 820
            |....|:::||.|:.||...:.|::||||:.....:|..||:.:...||:||||.::|.:|..:.
Zfish   849 STAVSEKKVLLEALTCSDNIFLLNRLLNLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREK 913

  Fly   821 IKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEI--AFRRILELGEDN 883
            ...:...||......::|::.:.:.:.||.|||.|:.|:.|.     |.|.  ||.|.:|:.:.|
Zfish   914 WDILNSRYGEALFMNSKLISGVTEFLNTEAELNELKEFILTS-----GGESAPAFARAVEIVQAN 973

  Fly   884 ISWH---NRQYHNLL 895
            :.||   ..|::..|
Zfish   974 VKWHILFQEQFYQWL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	97/324 (30%)
		Peptidase_M1	25..392	CDD:279741	104/375 (28%)
		GluZincin	30..480	CDD:301352	130/463 (28%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	109/407 (27%)
		M1_APN_2	118..568	CDD:189008	130/462 (28%)
		ERAP1_C	649..968	CDD:288671	97/324 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940