DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and anpepa

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	923	Identity:	237/923 - (25%)
Similarity:	413/923 - (44%)	Gaps:	111/923 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NLRPLHYNLSL-----------LTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENV 79
            :|.|..||:.|           .||...|     |:|...:|:...:.:..:.|..:.:.|  ..
Zfish    67 SLIPESYNVFLQPYLYAAITNNYTEQSYL-----FTGNSTVRVNCTKTSSRVFLHVHNINV--TA 124

  Fly    80 LLVRRNTGGRVTVRKMWQ--ASSVHQLGIVFNSMLWLGEEYTLVVQFSGQ-LSRASGYFVGGY-- 139
            :.||::........|.:|  .:..:.|.|.....:.....|.:..:|.|: |...:|::...|
Zfish   125 VEVRKSDTNEKLPLKGYQIFKNETNFLDIHLEVAIKENGTYDIFTEFEGELLEDLTGFYASRYTG 189

  Fly   140 --MDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSN----MRVLKTSD 198
              .|.:...:::|.:.|.|..|.||||||:.....|.|.:.:.|.....|.||    .|.::.:.
Zfish   190 KGTDDEDEERFLATSLLQPTDARTVFPCFDEPAMKAVFTITIIHRPEIRARSNEDGDPRTIQING 254

  Fly   199 HEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKI----------ADQG 253
               .|::.|||:.|..||...|.|.|  :...|.:.:.||      .|.||          |...
Zfish   255 ---TDWIRTTFKPTKKMSSYLLGFII--YDTHTFSYVSKG------TRTKIHVHGRSEAIDAGHA 308

  Fly   254 DYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAK 318
            |||:..|..|:..:.::||..||..||||:.|||...::.|:.|.:||.|:..||..:.::|..:
Zfish   309 DYALETTETILSHYENIFGLRYPMSKIDQIALPDFGVRAMENWGFISYQESGLLYDKETASTFDE 373

  Fly   319 QQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVL 380
            :||.:.:|.|.||.|..:|...:.:   ||..|.:.|:|...|:.|  .|...:|.::|:.....
Zfish   374 EQVTTLIAHELAHQWFGNLVTMSWWNDLWLKEGFATYMSYKGVEAV--GWDLKDLIVLREIQTAF 436

  Fly   381 VEDSKSSAYPMSL-AYASKSS-------DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHK 437
            ..||.::::|:|: ||..::|       |.....|.|.:.|||.:.:|...|:..:::||.: .:
Zfish   437 QMDSLNTSHPLSMNAYDVQTSSQISELFDDITYSKGAAVLRMLATRMGENEFMKGVKMYLSK-FQ 500

  Fly   438 GSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLR 502
            ..::....||..|..::        .|||.:.|.:||.:.|||::.::.  ||.:  .:||:|
Zfish   501 FENTVPKDLWECLNMDT--------HIKVDEFMKTWTEEVGYPVLTIIT--DTGD--TSQEQF-- 551

  Fly   503 NPGKLMQK---RQQCWWVPLTFAT--AGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVV 562
                |::|   ....|.:|:.:.|  ||:..|     ..:.|.:|........:.:    |.|::
Zfish   552 ----LLKKEGGHDSLWHIPIKYMTLKAGVKEF-----PNFFTDKGPDPIPDFKIGK----DNWLL 603

  Fly   563 FNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGH 627
            .|:......|:.|||.||..:...|. .|...|....|.|||.|..|||.|..:...:|||...:
Zfish   604 ANINCTGFYRVNYDEENWNRLTAQLQ-KNHRIIPLINRGQLIDDAFNLARAHRLNVTIALNLTKY 667

  Fly   628 LRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDEL--FKRDGSA-----AEN 685
            |.|:.|:|.|::|...|::......::.:......::|:|:...::|.  :..:|:.     .:.
Zfish   668 LINDLEYIPWESALKNLDFFTLMFDRSEVYGPIMKYLRNLVTPLYEEYEEYTINGTIPIEKYTDQ 732

  Fly   686 ANITELMVIVLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLR 750
            .|    .|..:.::|...|..|...|...|:.....:|.|..:|...:||:|:..|.|.||..:.
Zfish   733 CN----QVNAITVACSNGLPECITMAKDLFSDYKNGSNPIHPNLRRAVYCSAVASGDEDDWEYVW 793

  Fly   751 RLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKK 815
            ..|.::.|:.|:..|..|::|::|.|.|::.|........:.|.|::...|.:|||..|..:|..
Zfish   794 EEYQKATVAAEKDKLRYALSCTKEIWLLNRYLQYTLEPSKIRKMDMVSTISYIAQNVAGQPLAWD 858

  Fly   816 YLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEI-AFRRILEL 879
            ::..:...|.:.||:....|..|:.|:.|..:||.||..|:...|..:|:...... |..:::|.
Zfish   859 FIRGHWSYITQEYGAGIISLGSLLDVVTKRFSTEVELEELKQLQREQIQDDKWIAARALEQVIER 923

  Fly   880 GEDNISW--HNRQ 890
            ...||.|  .|:|
Zfish   924 TAANIIWVKENKQ 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	83/324 (26%)
		Peptidase_M1	25..392	CDD:279741	105/400 (26%)
		GluZincin	30..480	CDD:301352	127/492 (26%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	110/424 (26%)
		M1_APN_2	71..535	CDD:189008	127/492 (26%)
		ERAP1_C	602..923	CDD:288671	83/325 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010