DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	907	Identity:	235/907 - (25%)
Similarity:	413/907 - (45%)	Gaps:	88/907 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRPLHYNLSLLTEVEPLKLSGN-FSGEVIIRLRVWRETRTIILSNNGLQ---VGENVLLVRRNTG 87
            |.|.:||::|...:....|... |:|:..:.....:||..|::.::.|.   ..|.........|
Zfish    74 LLPEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEKHHAELMGLG 138

  Fly    88 G--RVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMDSKHHPQWI 149
            |  ...:.|.|.......:.|.....|.:|:.|.|..:|.|:|: ...|::...|:::... :.:
Zfish   139 GTRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGFYRSEYVENGVE-KVV 202

  Fly   150 AVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSD--HEKDDYVWTTFQQT 212
            |.||:.|..|.|.||||:..:..|.|.|.|.||.||.|::|.....|.:  .|....:.|.|:.|
Zfish   203 ATTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALANGMETGTENITIENQQVLQTRFEPT 267

  Fly   213 PAMSVQKLAFSINRFTNRTSAEIPKGP---ALTTWLRPKIAD--QGDYAISITPQIIVFFISLFG 272
            ..||...|||.|:.|   .|.:.|.|.   .:..|.|.:..:  :||||:::|..::.:..|.:.
Zfish   268 EKMSTYLLAFVISEF---PSIQSPLGANKILVRIWGRREAIENGEGDYALNVTFPVLKYLESYYN 329

  Fly   273 KPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDL 337
            ..||..|.||:.|||.:..:.|:.|||:|.|....|..:.|:...|:.|.:.::.|.||.|..:|
Zfish   330 TTYPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITVISHELAHMWFGNL 394

  Fly   338 ENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKS 399
            .....:   ||:.|.:.|||..|.|..||.|...||.:::|.......|:..|::|:|....:.:
Zfish   395 VTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALVSSHPLSSREDAVN 459

  Fly   400 SDTQANQ--------KSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDN 456
            :..|..:        |.|.:.|||...:....|...|..||| .|..|::....||..|||.:|:
Zfish   460 TPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQ-EHAYSNTVYTDLWKKLQEVADS 523

  Fly   457 QMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQC---WWVP 518
            ..::.....:.::|:.|.:|.|:|::.:    ||:..:::|:.||.:|..::.|....   |:||
Zfish   524 DGNVHLPASIEEIMNRWILQAGFPVVTI----DTHTGSISQQHFLIDPEAVVNKPSDYNYEWFVP 584

  Fly   519 LTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLI 583
            :|:...|     ..:...||.  .:.|:..|:..|.    .|::.||.:....|:.||.:||:.:
Zfish   585 ITWMKNG-----RNMGQHWLL--NKSTSYELMKTET----NWILANLNVTGYYRVNYDSQNWERL 638

  Fly   584 GNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLH 648
            ...|: ::..:|....|.|:|.|...||.|.::...:||....:|.||.|:|.|::|...||:..
Zfish   639 IKQLT-SDHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYIPWESAIRNLEYFF 702

  Fly   649 RTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITEL---------MVIVLQLSCRTDL 704
            ....:|.:....:.::|..::..| ..||     ...:|.|..         .:..:.::|:|.:
Zfish   703 LMFDRTEVRGPLEAYLRRKVEPLF-HYFK-----VITSNWTRKPTRHMDQYNQLNAITMACKTRV 761

  Fly   705 ESCADFA-------LKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEER 762
            ::|::..       :|:     ...|.:|.||...:||.||..|...:|.....::..|.|:.|.
Zfish   762 KACSELTSMWYRQWMKD-----PNVNPVPSDLKTVVYCNAIAAGGVEEWDFGWAMFKNSTVAAEA 821

  Fly   763 RILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKL 827
            ..|:..::|::|.|.|::.|:.|.....:.|.||......:|.|.:|..:|    .|..:|..:|
Zfish   822 EKLMYGLSCTKEPWLLNRYLHYAIDPNLIRKQDVTYPIVYIASNVIGQPLA----WDFFRAKWQL 882

  Fly   828 YGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEI---AFRRILELGEDNISW 886
            .   |.|...|:..::|..:||.:|..|:.|.....::  |..:   |..:.:|..:.|:.|
Zfish   883 M---TTEFRVLILGIVKTFSTEFQLQQLQRFQEEVAES--GVSLGTHAIEQAIEQTKANVKW 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	79/335 (24%)
		Peptidase_M1	25..392	CDD:279741	110/381 (29%)
		GluZincin	30..480	CDD:301352	132/474 (28%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	132/472 (28%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	81/340 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010