DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and SP1029

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster

Alignment Length:	937	Identity:	307/937 - (32%)
Similarity:	498/937 - (53%)	Gaps:	51/937 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPWYLI---VLHLCLPIGGTGATA-----------SNLRPLHYNLSLLTEVE-PLKLSGNFSGEV 53
            :.|:|:   .|.|.|....:.|.:           ::|||..|:|.:||.:| |..|  .|||.|
  Fly     1 MKWFLLFVAALGLGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDL--RFSGSV 63

  Fly    54 IIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSV---HQLGIVFNSM-LWL 114
            .|.:.....|:.:.|.:..|.:.|:.:.:|: .||.........:::|   |...|:.... |..
  Fly    64 KILIEALENTKNVTLHSKNLTIDESQITLRQ-IGGEGKKENCVSSTAVNPSHDFYILNTCQELLA 127

  Fly   115 GEEYTLVVQFSGQLSR-ASGYFVGGYMDS-KHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFIL 177
            |..|.|.:.|:..|:| ..||:...|.|. .:..:||:|||..|..|...||||:...|.|||::
  Fly   128 GNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVV 192

  Fly   178 NLAHPRGTNAVSNMRVLKTSDHEK-DDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPAL 241
            .|.:.:...|:|||...:|..||. .||:|..||::..||...:|:|:|.|:::.|. :|.....
  Fly   193 TLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPST-LPNSALF 256

  Fly   242 TTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAF 306
            .||.||...||.|||....|:::.::...||..:|..||||:.:||.:..:.|:.|||:|.|.|.
  Fly   257 RTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIAL 321

  Fly   307 LYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFH 368
            ||||..|:...||:|||.||.|.||.|..:|.....:   ||:.|.:.||:...|:|:.|.||..
  Fly   322 LYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSM 386

  Fly   369 ELSMVRQALAVLVEDSKSSAYPMS-----LAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNAL 428
            |...:...|.:...|:..|::|:|     ::..|:|.|..:.||.:.:.||:|..:|.::|.:.|
  Fly   387 EQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGL 451

  Fly   429 RLYLQR-SHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNE 492
            :.|||: |:|  ::.|..||.:|.:.:....||.:...:..:|||||:|.|||:|.|.|:|....
  Fly   452 QAYLQKFSYK--NAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAART 514

  Fly   493 VTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQP 557
            ..:.|||:|.|.......|..||||||::.|..:..|.:|.|..|:.|.....:.|..:.::..|
  Fly   515 AKLNQERYLLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGP 579

  Fly   558 DKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLAL 622
            |:||:||.:|:|..::.||.:||:|:...|:..:...|....|||||.|.|.||..|...|::|:
  Fly   580 DQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAM 644

  Fly   623 NFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDG-----SA 682
            ..:.:|:.|.|::.|::|...|:.:.|.:|||.....||.:|:.|:...::.|   :|     ||
  Fly   645 RLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL---NGINDTFSA 706

  Fly   683 AENANITELMVIVLQLSCRTDLESCADFALKEFAGLTLET-----NRIPVDLSETIYCTAIQFGT 742
            ....:...|..:|:..:|:..:..|...||..:.....|.     |.:|:::..|:|||:|:.|:
  Fly   707 IPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGS 771

  Fly   743 EADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGR-YMPKDDVLLIFSAVAQN 806
            ::||..|...|.:|||:.|:|.:|:|:.||||.|.|.:.|.|.|..: .:.|.|.:..|.|||.|
  Fly   772 DSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFN 836

  Fly   807 PLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEI 871
            .:|:.:||||.:||:..|.|.|...|.::::|::.|.::|.|..:.|..:.|:....|:|.|.|.
  Fly   837 EVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQ 901

  Fly   872 AFRRILELGEDNISWHNRQYHNLLAAV 898
            |.::.||:...|:.|..|.||.:..::
  Fly   902 AIQQTLEIMLTNVQWKERNYHQMSRSI 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	106/327 (32%)
		Peptidase_M1	25..392	CDD:279741	130/377 (34%)
		GluZincin	30..480	CDD:301352	157/466 (34%)
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	135/401 (34%)
		M1_APN_2	43..502	CDD:189008	157/464 (34%)
		ERAP1_C	583..908	CDD:288671	106/327 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449984
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850