DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and ERAP1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	960	Identity:	236/960 - (24%)
Similarity:	428/960 - (44%)	Gaps:	149/960 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IKLPWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTI 66
            |:||.|:|.:|..|.|             |.||:.||          |.|...:.:...:.|.||
Human    52 IRLPEYVIPVHYDLLI-------------HANLTTLT----------FWGTTKVEITASQPTSTI 93

  Fly    67 ILSNNGLQVGENVLLVRRNTGGRVTVR--KMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS 129
            ||.::.||:....|  |:..|.|::..  ::.:.....|:.::....|.:|..||:|:.::|.||
Human    94 ILHSHHLQISRATL--RKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLS 156

  Fly   130 RA-SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRV 193
            .. .|::...|...:...:.:|.||..|..|...||||:...|.|.|.:.:.......|:|||.:
Human   157 ETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPL 221

  Fly   194 LKT--------SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPK-GPALTTWLRPKI 249
            :|:        .||         |..|..||...:||.|:.|  .:.::|.| |..::.:..|..
Human   222 VKSVTVAEGLIEDH---------FDVTVKMSTYLVAFIISDF--ESVSKITKSGVKVSVYAVPDK 275

  Fly   250 ADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRST 314
            .:|.|||:.....::.|:...|..|||..|.|...:||....:.|:.||.:|.|:|.|:.|::|:
Human   276 INQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSS 340

  Fly   315 TRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVR-- 374
            ..:|..:...||.|.||.|..:|.....:   ||:.|.:.::...:|....|..:..:....:
Human   341 ASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCF 405

  Fly   375 QALAVLVEDSKSSAYPMSL-----AYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR 434
            .|:.|   |:.:|::|:|.     |...:..|..:..|.|.:..||...:...||.:.:..|||:
Human   406 DAMEV---DALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQK 467

  Fly   435 SHKGSSSNQAFLWHTL-------------------QEESDNQMSLRQDIKVSQLMDSWTMQPGYP 480
             |...::....||.::                   |..|.:....::.:.|..:|::||:|.|:|
Human   468 -HSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFP 531

  Fly   481 LIRV-VRNYDTNEVTVTQERFLR------NPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWL 538
            ||.: ||.   ..|.:.||.:::      :.|.|       |.|||||.|:..|     :...:|
Human   532 LITITVRG---RNVHMKQEHYMKGSDGAPDTGYL-------WHVPLTFITSKSD-----MVHRFL 581

  Fly   539 TCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQL 603
            .   :.....|||.|..:   |:.||:.:.....:.|::..|..:...|.||: :::....||.|
Human   582 L---KTKTDVLILPEEVE---WIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTH-TAVSSNDRASL 639

  Fly   604 ISDVLNLAGAGVVTYDLALNFLGHLRNEDEFI-VWQAADTYLEWLHRTLRQ---TTIISTFKGF- 663
            |::...|...|.::.:.||:...:|::|.|.: |:|..:..:. :::.:.:   ..:.:.||.|
Human   640 INNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIP-MYKLMEKRDMNEVETQFKAFL 703

  Fly   664 ---MRDLL--QTKFDELFKRDGSAAENANITELMVIVLQLSCRTDLESCADFALKEFAGLTLETN 723
               :|||:  ||..||     ||.:|....::|::    |:|..:.:.|...|...|.... |:|
Human   704 IRLLRDLIDKQTWTDE-----GSVSERMLRSQLLL----LACVHNYQPCVQRAEGYFRKWK-ESN 758

  Fly   724 ---RIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSREN-----WALDK 780
               .:|||::..::....| .||. |..|...|..|..|.|:..:..|: |..:|     |.||:
Human   759 GNLSLPVDVTLAVFAVGAQ-STEG-WDFLYSKYQFSLSSTEKSQIEFAL-CRTQNKEKLQWLLDE 820

  Fly   781 LLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKE 845
                :|.|..:...:...|.:.:.:||:||.:|.::|..|...:::.:...:..:|.:|.....:
Human   821 ----SFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQ 881

  Fly   846 VTTEEELNALRMFMRTDLQNLPGFEI-AFRRILELGEDNISWHNRQYHNL 894
            .:|...|..::.|..:..:|  |.:: ..::.:|..|:||.|.::.:..:
Human   882 FSTRTRLEEVKGFFSSLKEN--GSQLRCVQQTIETIEENIGWMDKNFDKI 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	76/335 (23%)
		Peptidase_M1	25..392	CDD:279741	100/383 (26%)
		GluZincin	30..480	CDD:301352	123/490 (25%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	126/509 (25%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	78/339 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850