DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and Npepps

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_536320.1	Gene:	Npepps / 50558	RGDID:	619962	Length:	920	Species:	Rattus norvegicus

Alignment Length:	913	Identity:	211/913 - (23%)
Similarity:	380/913 - (41%)	Gaps:	116/913 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQV-------------- 75
            :.:.|::|:|.|    :|..|...|.|::....:|.:.|..|:::...:.:
  Rat    57 TEVSPINYSLCL----KPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIH 117

  Fly    76 --GENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVG 137
              |.|.    :|...:||              :.|.|.|..|.. ||.:.|.|:|: :..|::..
  Rat   118 ATGFNY----QNEDEKVT--------------LSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRS 163

  Fly   138 GYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKD 202
            .|.......::.||||.....|...|||::.....|.|.::|..|:...|:|||.|:....:..|
  Rat   164 RYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDD 228

  Fly   203 D-YVWTTFQQTPAMSVQKLAFSINR--FTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQII 264
            : .|...|.:||.||...:||.:..  |....|.:   |..:..:.....|:||.:|:.:..:.:
  Rat   229 ENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKD---GVCVRVYTPVGKAEQGKFALEVAAKTL 290

  Fly   265 VFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEF 329
            .|:...|..|||..|||.:.:.|.|..:.|:.|||:|.|.|.|...:.|.:.::|.||..|..|.
  Rat   291 PFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHEL 355

  Fly   330 AHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAW----RFHELSMVR-QALAVLVEDSKS 386
            ||.|..:|.....:   ||:.|.:.::....||:..|.:    :|......| |.|     |:..
  Rat   356 AHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQEL-----DALD 415

  Fly   387 SAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFL 446
            :::|:.::....|.     |..:..|.|.:.||||..||.:.|...:.:||.:..:.:::.:. |
  Rat   416 NSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATED-L 479

  Fly   447 WHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKR 511
            |.:|:..|..        .::.:|::||.|.|:|||.|      ....|..:|.|    ||.||:
  Rat   480 WESLESASGK--------PIAAVMNTWTKQMGFPLIYV------EAEQVEDDRVL----KLSQKK 526

  Fly   512 ---------QQC--WWVPLTFATAGIDSFVSTLPSE-WLTCQGRQTASPLILNEVAQPDKWVVFN 564
                     :.|  |.||:|.:|       |..|:: .|.....:....::|..| :||:||..|
  Rat   527 FCASGPYVGEDCPQWMVPITIST-------SEDPNQAKLKILMDKPEMSVVLKNV-KPDQWVKLN 583

  Fly   565 LRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLR 629
            |......|..|..   .::.:.|.|....|:....|..|.:|:.:||.||:::....|..:....
  Rat   584 LGTVGFYRTQYSS---AMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFV 645

  Fly   630 NEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKR---DGSAAENANITEL 691
            ||..:.||......|..|...|..|......:.|::|:    |..:.:|   |....|......|
  Rat   646 NEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDV----FSPIGERLGWDPKPGEGHLDALL 706

  Fly   692 MVIVLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRS 756
            ..:||....:...::..:.|.:.|.........:..||...:|.|.::.|......::.:|:.::
  Rat   707 RGLVLGKLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQA 771

  Fly   757 NVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNI 821
            ::.||:..:...:..:.....:.|:|..|.:....|:|.|.:|......:..|...|.|::.||.
  Rat   772 DMQEEKNRIERVLGATLSPELIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNW 836

  Fly   822 KAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISW 886
            :.:...|.... .:::|:.:.::....::....::.|..:  ...|..|...::..|....|.:|
  Rat   837 EELYNRYQGGF-LISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQCCENILLNAAW 898

  Fly   887 HNR 889
            ..|
  Rat   899 LKR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	60/319 (19%)
		Peptidase_M1	25..392	CDD:279741	100/394 (25%)
		GluZincin	30..480	CDD:301352	121/482 (25%)
Npepps	NP_536320.1	Peptidase_M1	54..442	CDD:279741	102/415 (25%)
		M1_APN_2	62..505	CDD:189008	121/482 (25%)
		ERAP1_C	580..891	CDD:288671	60/320 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820