DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and Lvrn

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	931	Identity:	241/931 - (25%)
Similarity:	388/931 - (41%)	Gaps:	126/931 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSG---NFSGEVIIRLRVWRETRTI 66
            ||.    ||.||        ..|.||||:|.|...::|..||.   .|:|.|.|.:|....|.|:
  Rat    89 PWD----HLRLP--------PWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTL 141

  Fly    67 ILSN---NGLQV---GENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFS 125
            :|.:   |..||   |......|..|.|||.:..:|.|..:..:.:.....|..|..|.|...||
  Rat   142 LLHSFFLNYKQVEVWGPLAPDTRNATVGRVPLENVWFALDMQYVVLDLGQSLDPGSSYELNFDFS 206

  Fly   126 GQLSR--ASGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAV 188
            ||:.:  :.|.|:..|.|.......|| ||:.|..|..|||||:.....|.|.:.:.|..|..|:
  Rat   207 GQVLQEGSEGLFLNLYTDEDQLRALIA-TQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVAL 270

  Fly   189 SNMRVLKTS---DHEKDDYVWTTFQQTPAMSVQKLAFSINRF--TNRTSAEIPKGPALTTWLRPK 248
            |||..|..|   |.....:..|:|..||.|....:|..|..|  .:||.    :|..:..|.|..
  Rat   271 SNMPQLGQSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTE----RGKEIRVWARKD 331

  Fly   249 IADQG--DYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQ 311
            ....|  |:|.:.|..:..|...||...||..|.|.:.||.....:.|:.||:.: :|:.|....
  Rat   332 DIADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-DASLLLELD 395

  Fly   312 RSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDY----VSGFAVDNVEPAWRF-- 367
            ......:..:.|.::.|..|.|..:|...:.:   ||:.|.:.|    ::.:....|.....|
  Rat   396 DDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKVPRNMIFFL 460

  Fly   368 ---HEL-----SMVRQALAVLVEDSKSSAYPMSLAYASKSSDTQANQKSALLFRMLHSLIGTQAF 424
               |::     |:..:|::..||:...:      ...::..|....:|.|.:..||...:....|
  Rat   461 TVLHDILEDDHSLESRAVSTPVENFTET------REINRLFDIYTYKKGACMAWMLAGFLSQHLF 519

  Fly   425 LNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYD 489
            :|||:.||: :...|::.|..||..:|...|.|..:.....|.::|||||.|.|:|:|.:  |..
  Rat   520 INALKSYLE-TFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITL--NAS 581

  Fly   490 TNEVTVTQERF----LRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLI 550
            |.  .|.||.|    :.|...|   ....|.||:.:...||     |.|..||      ..|.:|
  Rat   582 TG--VVKQEPFYLERVENQTLL---SHNTWIVPIFWMKNGI-----TQPLVWL------DKSSMI 630

  Fly   551 LNEVAQPDK---WVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAG 612
            ...:...|.   ||:.|..:....|:.||:..|:.:...|. .:..:|....|.||:||...|:.
  Rat   631 FPGMKLSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQLE-KDPKAIPVINRLQLVSDAFALSK 694

  Fly   613 AGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFK 677
            ...:..:.||:...::..|||.:||      .|.|...:.:..:......::..||:..|.:...
  Rat   695 NNYIEIETALDLTKYIAKEDEILVW------FEVLVNLINREVVYDVKNYYLYPLLKKYFLKRLN 753

  Fly   678 ----------RDGSAAENANITELMVI--VLQLSCRTDLESCADFALKEF-AGLTLETNRIPVDL 729
                      |:..|:...|...|:.:  ..:.:|...||.|...:.:.| ..:......||..:
  Rat   754 SIWTIYSAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMAHPETAIPPQI 818

  Fly   730 SETIYCTAIQFGTEADWTLLRRLYTRSNVSEERR---ILLSAMACSRENWALDKLLN---LAFAG 788
            .:.:.|.||..|:..||..|..||.  |.:||:.   .|:.||.||::...|::.:.   ..|..
  Rat   819 EKVVLCNAIALGSNKDWDFLFNLYI--NKTEEQEDLFHLVHAMGCSKDPRTLNRFMEYDITVFPS 881

  Fly   789 RYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEV-TTEEEL 852
            |:...:    :...||::.:|..:||.:|::|..|:.:     :..|:.|:......| ||..|.
  Rat   882 RFNETN----LIEVVAESEVGRYVAKDFLINNWVAVYE-----SPSLSPLLQQYFVSVWTTIAEH 937

  Fly   853 NALRMFMRTDLQN-LPGFEIA 872
            :::.  :|.|.|: ..|:.:|
  Rat   938 SSVH--LREDCQHRSAGYGVA 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	76/333 (23%)
		Peptidase_M1	25..392	CDD:279741	110/401 (27%)
		GluZincin	30..480	CDD:301352	134/484 (28%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	131/479 (27%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	66/284 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040