DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG14516

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	250/903 - (27%)
Similarity:	430/903 - (47%)	Gaps:	62/903 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NLRPLHYNLSLLTEVEPLKLSGN--FSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRR---- 84
            ::|||.||::    :|| :||||  |:|.|.||:||..:...|.:....|.:..:...|.|
  Fly   117 SIRPLKYNIT----IEP-QLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNN 176

  Fly    85 --NTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSRASGYFVGGYMDS---KH 144
              ..|..:.:.|.:...:.....|.....|....||.:.::|.|.:   ..|..|.|..|   .:
  Fly   177 GEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGII---EDYLQGFYRSSYEVHN 238

  Fly   145 HPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDH-EKDDYVWTT 208
            ..:|:|.||.....|...||||:.....|.|.|::|.||....:|||.::.::|| ....|||..
  Fly   239 ETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDH 303

  Fly   209 FQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGK 273
            |.::..||...:|::|:.||:.:|..      ...|.|.......:||:|:.|:|:.|....|..
  Fly   304 FAESLPMSTYLVAYAISDFTHISSGN------FAVWARADAIKSAEYALSVGPRILTFLQDFFNV 362

  Fly   274 PYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLE 338
            .:|..|||.:.||:....:.|:.||:::.|.|.||....:|...||:|||.|..|.||.|..:|.
  Fly   363 TFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLV 427

  Fly   339 NAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAY----- 395
            ..:.:   ||:.|.:.|:.....|.|.|.|:..:..:|.:..||...|:.|:::.:|...
  Fly   428 TPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQE 492

  Fly   396 ASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSL 460
            .|:..|..:..|.:.:.||:...:....|...|..|||.. ..:|:.|..|||.|..|:.:...|
  Fly   493 ISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEM-AYNSATQDDLWHFLTVEAKSSGLL 556

  Fly   461 RQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFL-----RNPGKLMQKRQQCWWVPLT 520
            .....|.::||:||:|.|||:::|.|:.:::.:.:.|.||:     |....|:      |::|:|
  Fly   557 DDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLL------WYIPIT 615

  Fly   521 FATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGN 585
            |.|....:|.:|.|:.|:.    :|....:.|......||.:||::.....|:.||..||..|..
  Fly   616 FTTDSELNFANTRPTTWMP----RTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITE 676

  Fly   586 ALSGT-NASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHR 649
            .|... |...|....|||||.||:|||....::|:.|:|...:|.:|...:.|:||.:...::..
  Fly   677 HLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDS 741

  Fly   650 TLRQTTIISTFKGFMRDLLQTKFDEL-FKRDGSAAENANITELMVIVLQLSCRTDLESCADFALK 713
            ....:......|.::...|:..:|:: ||.....:|:..:......:|.::|....:.|...|.:
  Fly   742 MFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASR 806

  Fly   714 EFAGLTLET------NRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACS 772
            .|.. .::|      |.|..:|...:||:|||:|||.:|......:.::||..|:.:||:|:.||
  Fly   807 HFQN-WMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCS 870

  Fly   773 RENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQ 837
            :|.|.|.:.|....:|:::.|.|:..:|:||:...:|.|||..:|.:|.:.|....||....:..
  Fly   871 KEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHT 935

  Fly   838 LVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISWHNRQYHNLL 895
            |.....|...::.:|.....|::....:   ::...::|:|..|.::.|.|:.|.:::
  Fly   936 LFKFATKGFNSKFQLGEFENFVKDAHWD---YDRPVQQIVEHIETSVDWMNKNYKSIV 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	85/324 (26%)
		Peptidase_M1	25..392	CDD:279741	112/380 (29%)
		GluZincin	30..480	CDD:301352	136/469 (29%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	115/401 (29%)
		M1_APN_2	121..576	CDD:189008	136/469 (29%)
		ERAP1_C	652..974	CDD:288671	85/325 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850