DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG31233

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	852	Identity:	218/852 - (25%)
Similarity:	374/852 - (43%)	Gaps:	96/852 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LCLPIGGTGATASNLR------PLHYNLSLLTEVEPLKLSGN--FSGEVIIRLRVWRETRTIILS 69
            |.:|:    |...|.|      |.||.:||.|.|.    :|:  |:|.|.|.|.|...|..|::.
  Fly    46 LVVPL----ADEDNYRLPYDTIPSHYAVSLSTNVH----TGDTVFNGTVAITLSVLNTTTKIVVH 102

  Fly    70 NNGLQVGEN--VLLVRRNTGGRVTVRKMWQASSVHQL------GIVF-NSMLWLGEEYTLVVQFS 125
            ...|   ||  ..::::.....|....:::..:..:.      |:.| ....|:     |.:.:.
  Fly   103 ARQL---ENFTASIIQQGVTEAVAQELVYEYEAEREFLTFSKTGLTFPEDTTWI-----LTINYQ 159

  Fly   126 GQL-SRASGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVS 189
            |.| :...|:::..|.|.:.:.:::|.||.....|...|||::..:..|.|.:.:.|....||:|
  Fly   160 GHLRTDNGGFYLSTYTDEEGNTKYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAIS 224

  Fly   190 NMRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFT--------------NRTSAEIPKGPA 240
            ||.|    |......| |.||:|..|....:||.::.|.              :|...|..:..|
  Fly   225 NMPV----DSSSTSGV-TVFQKTVNMPSYLVAFIVSEFVFSEGELNGLPQRVFSRNGTEHEQEWA 284

  Fly   241 LTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAA 305
            |||.:..:....|                .|..|:...|:||..:||.|..:.|:.||.:|.|..
  Fly   285 LTTGMLVEKRLSG----------------YFDVPFALPKLDQAGIPDFAAGAMENWGLATYREEY 333

  Fly   306 FLYSAQRSTTRAKQQVASHVAQEFAHHWLSDL---ENAALYWLHNGLSDYVSGFAVDNVEPAWRF 367
            .||:.:.|||..:..:|:..|.|.||.|..||   |..:..||..|.:......|||...|.|..
  Fly   334 LLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDI 398

  Fly   368 HELSMVRQALAVLVEDSKSSAYPMSLAYASKSS------DTQANQKSALLFRMLHSLIGTQAFLN 426
            .:........:.||.|:.::|.||| .:..|.|      |:.:..|:..:..|....:....|..
  Fly   399 FQTFHAGSYQSALVNDASANARPMS-HFVQKPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQR 462

  Fly   427 ALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIK--VSQLMDSWTMQPGYPLIRVVRNYD 489
            .|..||. .::.:::|.:.|:..:.:.:..:   ..::|  |..:|.|||.|.|.||:.|.||||
  Fly   463 GLHNYLV-DNQFTAANPSKLFEAIAKAAVEE---NYEVKATVPDMMGSWTNQGGVPLLTVTRNYD 523

  Fly   490 TNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEV 554
            ....||.|..:..:......|   .|:||:.:|.:....|.:|..:.:|..|...|    |.:::
  Fly   524 NGSFTVKQSVYTNDKDYTNDK---LWYVPINYAESKNPDFRNTEATHYLLNQSEIT----IYSDL 581

  Fly   555 AQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYD 619
            .|.: |::.|.:.....|:.||.:|:|||.:||. |....||...|||||:|:...|.:|.|.:.
  Fly   582 DQTN-WLILNKKSTGYYRVLYDAQNYQLITSALI-TRPHKIDPRNRAQLINDLYRFATSGRVPHA 644

  Fly   620 LALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAE 684
            ..|..|.:|..||::..|.|.:|.:..|:|.|........|:.::|:|:..:||: |..:.:..:
  Fly   645 TLLELLTYLPQEDQYSPWSATNTVITLLNRYLSGDADYGNFQFYVRELVSLQFDK-FGVNDNKGD 708

  Fly   685 NANITELMVIVLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLL 749
            :..:.....:::.|:|...||:|......:...|..|..:|..:|...:||..::...:..:..:
  Fly   709 HHLVPFTRNVLINLACLAGLENCLTETTAKLTALVEEGTKIEPNLQSQVYCNGLKQADDKTFDFV 773

  Fly   750 RRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAV-AQNPLGYNIA 813
            ......|....|||:|:||:.||:....|:|.:..:.....:...:.:.:.|.| ::..:|..:|
  Fly   774 FNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRGEVGLLVA 838

  Fly   814 KKYLVDN 820
            .::|..|
  Fly   839 IEFLQKN 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	67/261 (26%)
		Peptidase_M1	25..392	CDD:279741	104/401 (26%)
		GluZincin	30..480	CDD:301352	122/486 (25%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	108/419 (26%)
		M1_APN_2	65..514	CDD:189008	122/486 (25%)
		ERAP1_C	587..905	CDD:288671	67/261 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940