DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG8774

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	222/899 - (24%)
Similarity:	386/899 - (42%)	Gaps:	82/899 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGR 89
            :||.|.||.|....::|    :|||:|:..|.::|...|..|||.:..|.:....:|.|.
  Fly    70 TNLVPTHYELYWHPDLE----TGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNRE----- 125

  Fly    90 VTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQL-SRASGYFVGGYMDSKHHPQWIAVTQ 153
              |.|.........|.|.....|.:....||.:.|.||: .:..|.:...|::.....:.|:.|:
  Fly   126 --VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188

  Fly   154 LAPNLANTVFPCFENRTFLAPFILNLAHPRGT-NAVSNMRVLKTSDHEKDDYVWTTFQQTPAMSV 217
            ..|..|...||||:.....|.|.:.:.||.|: :|||||:  :|..:...||....|:.:.:||.
  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQ--QTESNYLGDYTEAIFETSVSMST 251

  Fly   218 QKLAFSINRFTNRTSAEIPKGP----ALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAM 278
            ..:...::.|.::::.....|.    ::..:......::.::|:.....:..::|..:..|||..
  Fly   252 YLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLT 316

  Fly   279 KIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY 343
            |:|...:||.|..:.||.|||:|.|.|.||....|:|..||.:|..:|.|.||.|..:|.....:
  Fly   317 KLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWW 381

  Fly   344 ---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKSS----- 400
               ||:.|.:.|:....|:.|.|.|...|...:.....||:.|:|.|::|:.....|...
  Fly   382 NDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIF 446

  Fly   401 DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIK 465
            ||.:.:|...:.|||.:|:|.:.|..|:..||.:....::....||...        .::..|:.
  Fly   447 DTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEV--------EAVVTDLD 503

  Fly   466 VSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQC-----WWVPLT-FATA 524
            :.:||.:||.|.|||::.|.:..| ....|||:|||.||....:.....     |.||:| ||..
  Fly   504 IKKLMLTWTEQMGYPVLNVSKVAD-GSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADD 567

  Fly   525 G----------IDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERN 579
            |          :||....:|||                     .:|:..|:......|:.|:|..
  Fly   568 GSENSFIYDYDVDSVGIAVPSE---------------------VQWIKLNVNQTGYYRVNYEESL 611

  Fly   580 WQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYL 644
            |.|:...|: |:.:..:...|..|::|...||.|..::|.:.|:...:|..|.:|:.|..|...|
  Fly   612 WALLIQQLT-TSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKL 675

  Fly   645 EWLHRTLRQTTIISTFKGFMRDLLQTKFDEL-FKRDGSAAENANITELMVIVLQLSCRTDLESCA 708
            ..|||:|..:....::..:.|.|:...::|: :..|   |:|.....|.|.:|..:|...:..|.
  Fly   676 RSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVD---ADNHLKNRLRVSILTAACALGVPDCL 737

  Fly   709 DFALKEFAG-LTLETNRIPVDLSETIYCTAIQFGT-EADWTLLRRLY-TRSNVSEERRILLSAMA 770
            ..|.:.|:. |...|.|...||.|.:|...:|..| ::.|..|.:|: ..::.||:.:::.....
  Fly   738 QQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSG 802

  Fly   771 CSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDEL 835
            .....:..|.|...:.....:...|.......:|.||:|..:..::..:....:...:|.|....
  Fly   803 VRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNF 867

  Fly   836 AQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISWHNR 889
            .:|:..:.....:..:|..::.|.....::..|.......: |..:.||.|.:|
  Fly   868 GRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAV-ETIKYNIEWLSR 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	66/320 (21%)
		Peptidase_M1	25..392	CDD:279741	104/375 (28%)
		GluZincin	30..480	CDD:301352	123/463 (27%)
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	107/396 (27%)
		M1_APN_2	75..518	CDD:189008	123/463 (27%)
		ERAP1_C	593..910	CDD:288671	66/321 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850