DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG8773

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	240/903 - (26%)
Similarity:	396/903 - (43%)	Gaps:	73/903 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GATAS----------NLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQV 75
            |.|||          .|:|.||:|.|...:|    :|.|||:..|.:.|...|..|:|.:..|.:
  Fly   111 GTTASPEKIDYRLPGTLKPTHYDLYLFPNIE----TGEFSGQETITITVEEATDQIVLHSLNLNI 171

  Fly    76 GENVLLVRRNTGGRVTVRKMWQASSVHQLGIVF--NSMLWLGEEYTLVVQFSGQL-SRASGYFVG 137
            ....::   |||............:|.:. ::|  |..|..|....|.:.|.|.: ::..|.:..
  Fly   172 SSVSIM---NTGSDTLEILETTVDAVREF-LIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSS 232

  Fly   138 GYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGT--NAVSNMRVLKTSDHE 200
            .|:......:|||.::..|..|...||||:.....|.|.:.|.||.|.  :|:|||.|  .|...
  Fly   233 SYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--DSSVS 295

  Fly   201 KDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGP----ALTTWLRPKIADQGDYAISITP 261
            :..:...||.::..||.....|.::.|..:..:...||.    :::.:..|:..|:.|.|::|..
  Fly   296 QGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGK 360

  Fly   262 QIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVA 326
            .:|.::|..|...||..|:|...:||....:.||.|||:|.|.:.||....|:...||::||.:|
  Fly   361 GVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIA 425

  Fly   327 QEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSA 388
            .||||.|..:|.....:   ||:.|.:.:|....||.|.|.|:..:...|....:||..|....:
  Fly   426 HEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGS 490

  Fly   389 YPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWH 448
            :|:.....:...     ||....|.:.|.|||...:|...|..|:..||......::....|.
  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFF-- 553

  Fly   449 TLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQ 513
               .|.|   .|.....|:::|.:||:|.|.|::.:.:..|| |..:||:|||.||.......:.
  Fly   554 ---TEID---KLELGYNVTEIMLTWTVQMGLPVVTIEKVSDT-EYKLTQKRFLSNPNDYDADHEP 611

  Fly   514 C-----WWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRI 573
            .     |.:|:|:.|:. ||.|..|   |......:     |...|....:|:.||.......|:
  Fly   612 SEFNYRWSIPITYFTSS-DSVVQRL---WFYHDQSE-----ITVTVPAAVEWIKFNADQVGYYRV 667

  Fly   574 TYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQ 638
            .||...|..:.:.|. ...|:.....||.|::|...||.:..:.|..|.....:|..|.:::.|.
  Fly   668 NYDTDLWNDLADQLV-VQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWS 731

  Fly   639 AADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVIVLQLSCRTD 703
            .|.:.|..|.|||..|:..:.:|.:...|::..:..|   ..:..|:.....|.|..|..:|...
  Fly   732 VAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTAL---TWTVGEDHLDNRLRVTALSAACSLG 793

  Fly   704 LESCADFALKEF-AGLTLETNRIPVDLSETIYCTAIQ-FGTEADWTLLRRLYTRSNVSEERRILL 766
            ||||...|.::| |.|....:|...|:.||:|...|| .|::.||..:..|:...:.:.|:..|:
  Fly   794 LESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLM 858

  Fly   767 SAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSN 831
            ..::..:..|.|.:.::||:...|:...|.....:.::.||:|.::...|:.:|.:.::..:|.|
  Fly   859 YGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLN 923

  Fly   832 TDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLP--GFEIAFR-RILELGEDNISW 886
            ...|..|:..:....:|:.:|..:..|    ....|  |...|.| |.||..::||.|
  Fly   924 ERYLGNLIPSITARFSTQTKLEEMEQF----FAKYPEAGAGTAARVRALETVKNNIVW 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	78/321 (24%)
		Peptidase_M1	25..392	CDD:279741	109/388 (28%)
		GluZincin	30..480	CDD:301352	128/466 (27%)
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	110/402 (27%)
		M1_APN_2	130..579	CDD:189008	128/466 (27%)
		ERAP1_C	655..969	CDD:288671	78/321 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850