DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and npepps

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	858	Identity:	204/858 - (23%)
Similarity:	357/858 - (41%)	Gaps:	95/858 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQV---------GENVL 80
            :::.|::|.|.|    :|..:...|.|::...:.|.:.|..|:::...:.:         ||.:.
Zfish    12 TDVYPVNYGLRL----KPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDIITASFVPDGGEEIN 72

  Fly    81 LV---RRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMD 141
            ..   .:|...:||              :.|.|.|..|.. :|.:.|.|:|: :..|::...| .
Zfish    73 ATGFNYQNEDEKVT--------------LCFPSTLQKGSG-SLKIDFVGELNDKMKGFYRSKY-S 121

  Fly   142 SKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKD-DYV 205
            |....::.||||.....|...|||::.....|.|.:.|..|:...|:|||.|:....:.:| ..|
Zfish   122 SSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSLV 186

  Fly   206 WTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISL 270
            ...|..||.||...:||.|..: :...::...|..:..:.....|:||.:|:.:..:.:.|:...
Zfish   187 EVKFATTPIMSTYLVAFVIGEY-DFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDY 250

  Fly   271 FGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLS 335
            |..|||..|||.:.:.|.|..:.|:.|||:|.|.|.|...:.|...::|.||..|..|.||.|..
Zfish   251 FSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFG 315

  Fly   336 DLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYAS 397
            :|.....:   ||:.|.:.::....||:..|.:......:.......|..|:..:::|:.:....
Zfish   316 NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGH 380

  Fly   398 KSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR-SHKGSSSNQAFLWHTLQEESDN 456
            .|.     |..:..|.|.:.||||:.||.:.|...:..||.: .||.:|:..  ||..|::.|..
Zfish   381 PSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTED--LWECLEQASGK 443

  Fly   457 QMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNE--VTVTQERFL----RNPGKLMQKRQQC- 514
                    .::.:|:|||.|.|:|:|.|.:....::  :.::|::|.    ||.       :.|
Zfish   444 --------PIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRND-------EDCP 493

  Fly   515 -WWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDER 578
             |.||::..|:...|...|   :.|..|...|.:   :..|| ||.|:..|.......||.|..
Zfish   494 NWMVPISICTSEDPSCTKT---KILLDQPETTVN---ITNVA-PDHWIKINPGTVGFYRIQYSS- 550

  Fly   579 NWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTY 643
              .::.:.|.|....::....|..|.:|:.:||.||:::....|..:....||..:.||......
Zfish   551 --AMLESLLPGIRDLTLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCN 613

  Fly   644 LEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVIVLQLSCRTDLESCA 708
            |..|...|..|......:.|:|||. |........|....|......|..:||....:...::..
Zfish   614 LGVLSSLLSHTDFHEDIQEFIRDLF-TPIGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATL 677

  Fly   709 DFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSR 773
            :.|.:.|.........:..||...:|.|.::.|.......:.:|:.::::.||:..:...:....
Zfish   678 EEARRRFREHVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKNRIERVLGAIP 742

  Fly   774 ENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDN-------------IKAII 825
            ....:.::||.|.:....|:|.|.:|......:..|...|.|::.||             |..:|
Zfish   743 APDLIQRVLNFALSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRYQGGFLISRLI 807

  Fly   826 KLY--GSNTDELA 836
            ||.  |...|::|
Zfish   808 KLTVDGFAIDKMA 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	61/291 (21%)
		Peptidase_M1	25..392	CDD:279741	95/383 (25%)
		GluZincin	30..480	CDD:301352	120/472 (25%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	97/404 (24%)
		M1_APN_2	17..459	CDD:189008	120/472 (25%)
		ERAP1_C	534..845	CDD:288671	61/291 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820