DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and LTA4H

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	676	Identity:	137/676 - (20%)
Similarity:	236/676 - (34%)	Gaps:	152/676 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRE---TRTIILSNNGLQVGENVLLVRRN 85
            ||..|..|.:|....:.....|:|..:      |.|..:   .|:::|....|.: |.|::..:.
Human    14 ASVCRTKHLHLRCSVDFTRRTLTGTAA------LTVQSQEDNLRSLVLDTKDLTI-EKVVINGQE 71

  Fly    86 TGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSRASG---YFVGGYMDSKHHPQ 147
            ....:..|:.::.|.:.     .:..:.|.:...:|::.|.:.|..|.   :........|.||.
Human    72 VKYALGERQSYKGSPME-----ISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPY 131

  Fly   148 WIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNA-VSNMRVLKTSDHEKDDYVWTTFQQ 211
            ..:..|...  ...:.||.:..:....:...::.|:...| :|.:|..:|.|.|........|.|
Human   132 LFSQCQAIH--CRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQ 194

  Fly   212 TPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYP 276
            ...:....:|..:....:|..     ||....|...:..::..|..|.|..::.....| |.||.
Human   195 KVPIPCYLIALVVGALESRQI-----GPRTLVWSEKEQVEKSAYEFSETESMLKIAEDL-GGPYV 253

  Fly   277 AMKIDQLVLPDTAYQSHEHLGLVSYP----EAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDL 337
            ..:.|.||||.            |:|    |...|.....:.....:.:::.:|.|.:|.|..:|
Human   254 WGQYDLLVLPP------------SFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNL 306

  Fly   338 ENAAL---YWLHNG----LSDYVSG------FAVDNVEPAW--------RFHELSMVRQALAVLV 381
            .....   :||:.|    |..::.|      |...|....|        .|.|.....:.:..|.
Human   307 VTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLT 371

  Fly   382 EDSKSSAYPMSLAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR-SHKGSSSN--Q 443
            :.....||          |.....:..||||.:...|.|.:.||..|:.|::: |:|..:::  :
Human   372 DIDPDVAY----------SSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWK 426

  Fly   444 AFLWHTLQEESD--NQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYD---TNEVTVTQERFLRN 503
            .||:...:::.|  ||:.          .::|...||.|.|:  .|||   ||......:|
Human   427 DFLYSYFKDKVDVLNQVD----------WNAWLYSPGLPPIK--PNYDMTLTNACIALSQR---- 475

  Fly   504 PGKLMQKRQQCWWVPLTFATAGIDSFVST----LPSEWLT---CQGRQTASPLILNEVAQPDKWV 561
                        |:  |.....::||.:|    |.|..|.   .|..|.| ||.|..:.:..:
Human   476 ------------WI--TAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRA-PLPLGHIKRMQE-- 523

  Fly   562 VFNLRLATPCRITYD------ERNWQ-LIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYD 619
            |:|........|.:.      :..|: .|..||.........:||| .|..|        :..:|
Human   524 VYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTR-PLFKD--------LAAFD 579

  Fly   620 LALNFLGHLRNEDEFIVWQAADTYLE 645
                     ::.|     ||..||.|
Human   580 ---------KSHD-----QAVRTYQE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	19/92 (21%)
		Peptidase_M1	25..392	CDD:279741	74/398 (19%)
		GluZincin	30..480	CDD:301352	93/486 (19%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	137/676 (20%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		1/4 (25%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		0/2 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810