DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9806 and LNPEP

DIOPT Version :9

Sequence 1:NP_572643.1 Gene:CG9806 / 31994 FlyBaseID:FBgn0030222 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_005566.2 Gene:LNPEP / 4012 HGNCID:6656 Length:1025 Species:Homo sapiens


Alignment Length:942 Identity:239/942 - (25%)
Similarity:394/942 - (41%) Gaps:170/942 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVR 93
            ||.|.|||    .|...|..|.|.|.|.::..:.|..|||.:.|..:            .|||. 
Human   174 PLRYELSL----HPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNI------------SRVTF- 221

  Fly    94 KMWQASSVH------------QLGIVFNSMLWLGEEYTLVVQFSGQLSRA-SGYFVGGYMDSKHH 145
             |...||..            |:.||....|..|..|||.:::|..:|.: .|::...|.|..:.
Human   222 -MSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNE 285

  Fly   146 PQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWTTFQ 210
            .::.|.||..|..|.:.||||:...|.|.||:.:.......|:||| ..|:|....|..|...|.
Human   286 KKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNM-PKKSSVVLDDGLVQDEFS 349

  Fly   211 QTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPY 275
            ::..||...:||.:....| .|.:: .|..::.:..|:...|..||:..|.:::.||.:.|...|
Human   350 ESVKMSTYLVAFIVGEMKN-LSQDV-NGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQY 412

  Fly   276 PAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENA 340
            |..|:|.:.:||....:.|:.||:::.|...||.:..|:...::.|...:|.|.||.|..:|...
Human   413 PLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTM 477

  Fly   341 ALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQAL----AVLVEDSKSSAYPMSLAYASK 398
            ..:   ||:.|.:.::..|:::.:     |.|||.....|    ..:.:||.:|::|:|.:..|.
Human   478 KWWNDLWLNEGFATFMEYFSLEKI-----FKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSS 537

  Fly   399 SS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQM 458
            ..     |:.:..|.:.|..||.:.:....|.:|:.||| .:|..:|.....||.:..|.::   
Human   538 EQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYL-HNHSYASIQSDDLWDSFNEVTN--- 598

  Fly   459 SLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRN--PGKLMQKRQQCWWVPLTF 521
               |.:.|.::|.:||:|.|:||:.|.:.  ..|:.:.||||..|  |..........|.:||::
Human   599 ---QTLDVKRMMKTWTLQKGFPLVTVQKK--GKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSY 658

  Fly   522 ATAGIDSFVSTLPSEWLTCQGR-----QTASPL-----ILNEVAQPDKWVVFNLRLATPCRITYD 576
            .|                 :||     |:.|.|     ::| :.:...||..|:.:.....:.|.
Human   659 VT-----------------EGRNYSKYQSVSLLDKKSGVIN-LTEEVLWVKVNINMNGYYIVHYA 705

  Fly   577 ERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEF-----IV 636
            :.:|:.:.:.|. .|...:....||.||:::..|||.|.|....|.:.:.:|.||:..     .:
Human   706 DDDWEALIHQLK-INPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEAL 769

  Fly   637 WQAADTY--LEWL-HRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVIVLQL 698
            :|....|  ||.| :..|....:...||     |||.:..:....|..   ..::.||...:|:.
Human   770 FQTDLIYNLLEKLGYMDLASRLVTRVFK-----LLQNQIQQQTWTDEG---TPSMRELRSALLEF 826

  Fly   699 SCRTDLESCADFALKEFAGLTLE--TNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEE 761
            :|..:|.:|:..|:|.|......  |..:|.|:..|::....:  |:..|:.|...|.......|
Human   827 ACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAE 889

  Fly   762 RRILLSAMACSRE----NWALDKLLN--------LAF----AGRYMPKDDVLLIFSAVAQN---- 806
            :..:|.|:|.|.:    .|.:...||        |:|    .||:.|..  ||.:..|.:|    
Human   890 KNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGH--LLAWDFVKENWNKL 952

  Fly   807 ----PLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLP 867
                |||     .|.:.||.|     ||         |.|.   :|:..|:.::.|....     
Human   953 VQKFPLG-----SYTIQNIVA-----GS---------TYLF---STKTHLSEVQAFFENQ----- 990

  Fly   868 GFEIAFR-----RILELGEDNISWHNRQYHNL 894
             .|..||     ..||:.:.||.|..:...:|
Human   991 -SEATFRLRCVQEALEVIQLNIQWMEKNLKSL 1021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9806NP_572643.1 ERAP1_C 561..878 CDD:288671 82/355 (23%)
Peptidase_M1 25..392 CDD:279741 106/382 (28%)
GluZincin 30..480 CDD:301352 129/474 (27%)
LNPEPNP_005566.2 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding 96..101
M1_APN_2 175..617 CDD:189008 129/474 (27%)
Substrate binding. /evidence=ECO:0000250 428..432 0/3 (0%)
ERAP1_C 689..1009 CDD:314669 85/360 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155402
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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