DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and erap1b

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	983	Identity:	240/983 - (24%)
Similarity:	428/983 - (43%)	Gaps:	138/983 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKLP--WYLIVL--HL---------CLPIGGTG--------ATASNLRPLHYNLSLLTEVEPLK 44
            |.:||  ..||||  ||         ..||..:|        .....:.||||||.    :.|..
Zfish     4 MTRLPVLLNLIVLPIHLWAAVTPEPTSFPISSSGEPFPWNKMRLPDTISPLHYNLL----IHPNL 64

  Fly    45 LSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFN 109
            .|.:|:|.|.|::.|.::|:||||.:..||: .:..|:..|...:..: |:.:.....|:.:|.:
Zfish    65 TSLDFTGSVQIQIEVLQDTKTIILHSKNLQI-SSARLLDANIAQQQPL-KVLEYPYFQQIALVSD 127

  Fly   110 -SMLWLGEEYTLVVQFSGQLSRA-SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFL 172
             ::|..|..|::.:.|:..||.: .|::...|..||...:.:|.||.....|...||||:...|.
Zfish   128 KALLKRGHVYSVELHFAANLSESFHGFYKSTYRTSKGDVRVVASTQFEATSARAAFPCFDEPAFK 192

  Fly   173 APFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRF--TNRTSAEI 235
            |.|.:.:.......|:|||..|:|.: .|:......|..:..||...:|:.::.|  .::||..
Zfish   193 ANFSVQIRREAKHIALSNMPKLRTLE-LKNGLFEDQFDVSVKMSTYLVAYIVSDFLSISKTSQH- 255

  Fly   236 PKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMK--------------------I 280
              |..::.:..|:..||.::|:....:::.|:...|..|||..|                    :
Zfish   256 --GVQISVYAVPEKIDQAEFALDAAVKLLDFYDDYFDIPYPLPKQEKPTIKHAKEEFSVYIICFV 318

  Fly   281 DQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY-- 343
            |...:||....:.|:.||.:|.|:|.|:...:|:...|..:...:|.|.||.|..:|.....:
Zfish   319 DLAAIPDFQSGAMENWGLTTYRESALLFDPHKSSASDKLGITMIIAHELAHQWFGNLVTMQWWND 383

  Fly   344 -WLHNGLSDYVSGFAVDNVEPAWRFHE--LSMVRQALAVLVEDSKSSAYPMSL-----AYASKSS 400
             ||:.|.:.::...:|:...|..:..:  |....:|:.|   ||.||::|:|.     |...:..
Zfish   384 LWLNEGFAKFMEFVSVNITNPELQVEDYFLGKCFEAMEV---DSLSSSHPVSTPVENPAQIQEMF 445

  Fly   401 DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR-SHKGS-SSNQAFLWHTLQEESD-------- 455
            |..:..|.|.:..||...:..:.|...:..||:. |::.: :||   ||.:|....|
Zfish   446 DDVSYDKGACILNMLREFLTPKIFKLGIVKYLKHYSYQNTVNSN---LWESLTNVCDSDGLDEGR 507

  Fly   456 ----------------NQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNP 504
                            ::.....::.|..:|::||:|.|:|||.:.  ....||.::|||:|::
Zfish   508 LKGDESCRHSASNTGASKWHSEDELDVKAMMETWTLQEGFPLITIA--VKGREVRLSQERYLKS- 569

  Fly   505 GKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLAT 569
            ..|.|.....|.||||:.|:.     ||....:|.   :.....|.|.|...   |:.||:.::.
Zfish   570 DDLSQTSSFLWQVPLTYITSD-----STTVHRFLL---KTKTDVLYLPEEVD---WIKFNVDMSG 623

  Fly   570 PCRITYDERNW-QLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDE 633
            ...:.|:...| .||  .|...|.:::....||.||::...|...|.:..|.||:...:|..|.|
Zfish   624 YYIVHYEGSGWDDLI--TLLKHNHTALSSNDRASLINNAFQLVSVGKLPLDKALDLTLYLSKETE 686

  Fly   634 FIVWQAADTYLEWLHRTLRQTTII---STFKGFMRDLLQTKFD-ELFKRDGSAAENANITELMVI 694
            .:........|..|::.:.:..::   :..||::..|.|...: :|:..:||.:|..    |...
Zfish   687 IMPVTQGFNELVPLYKLMEKRDMVELENQMKGYILQLFQKLIEQQLWTDEGSVSERM----LRSY 747

  Fly   695 VLQLSCRTDLESCADFALKEFAGLTLETN---RIPVDLSETIYCTAIQFGTEADWTLLRRLYTRS 756
            :|...|......|...|.:.| .|..:::   .:|.|::..::....:  ||..|..|...|..|
Zfish   748 LLLFGCVRGHPPCVSNATQLF-NLWRDSDGNMSLPNDVTMAVFSVGAR--TEDGWDFLFEKYKES 809

  Fly   757 -NVSEERRI---LLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYL 817
             .||.:.||   |:::....:..|.:::.|.    |..:...|:..:.::|::||..|..|..:|
Zfish   810 MYVSMKSRIKQALMTSPLDHKLKWMMEQSLE----GELIKTQDLPYVVTSVSRNPKAYKHAWDFL 870

  Fly   818 VDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEI-AFRRILELGE 881
            ..|..::||.:...:..:|.:|..:..:.:|.|.|..:|.|... ||...|.|: ..::.:|..|
Zfish   871 QANWDSLIKKFDLGSHSIAHMVVGVTNQYSTREMLAEVRNFFSL-LQPETGAELRCIQQAVENIE 934

  Fly   882 DNISWHNR 889
            :||.|.::
Zfish   935 ENIRWMDK 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	74/329 (22%)
		Peptidase_M1	25..392	CDD:279741	102/395 (26%)
		GluZincin	30..480	CDD:301352	124/509 (24%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	105/419 (25%)
		M1_APN_2	54..548	CDD:189008	124/509 (24%)
		ERAP1_C	615..932	CDD:288671	74/330 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850