DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG3502

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	269/922 - (29%)
Similarity:	430/922 - (46%)	Gaps:	95/922 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGEN---VLLVRRNTG 87
            ::.||||||.:||.:.  .....|.|.|.|.|.....|:.|.|....|::.||   |:..:...|
  Fly    33 SVEPLHYNLRILTHLN--STDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTSVVSGQEKFG 95

  Fly    88 -GRVTVRKMWQASSVHQLGIVFNSMLWLGEE------YTLVVQFSGQLSRA-SGYFVGGYMD--- 141
             .|:.|      :.||...|     |.||.|      |.|.:.|...|:.: |||:...|.|
  Fly    96 VNRIEV------NEVHNFYI-----LHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNYTDIVT 149

  Fly   142 -SKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEK-DDY 204
             ..||   :||||.:|..|...||||:..::.|.|.:.|.:.:....:|.|.||:..||:. .:|
  Fly   150 KEVHH---LAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLRCQDHDSLTNY 211

  Fly   205 VWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPAL--TTWLRPKIADQGDYAISITPQIIVFF 267
            ||.........|...:||:::...|..:.|......:  ..|::||:..|...::.|.|:::.|:
  Fly   212 VWCDHDTLLRTSTYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKLLGQEMISMEIAPKLLSFY 276

  Fly   268 ISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHH 332
            .:||...:|..|:|||.:|...:.:.|:.|||:|.|.....:......:.|...|..||.|:||.
  Fly   277 ENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTAFTVAHEYAHQ 341

  Fly   333 WLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLA 394
            |..:|.....:   ||..|.|.|....|:|:::|.||..|..:.|.......:||.:     ::.
  Fly   342 WFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDSNA-----TVP 401

  Fly   395 YASKSSDTQAN----------QKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHT 449
            ..||.....|.          :|.:|..||||.|:|.:||.:.:|.:|:|...|:.: ||.||::
  Fly   402 AISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVA-QADLWNS 465

  Fly   450 LQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQC 514
            ||..:.....:..|..:|:.|||||:|.||||:.::|||.|.|||:.|.||.:..|  ::|...|
  Fly   466 LQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQEHG--IEKASSC 528

  Fly   515 WWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQP-----DKWVVFNLRLATPCRIT 574
            |||||.|....:..|..|.|..||.|       ||....:..|     |:||:.|.::||..|:.
  Fly   529 WWVPLRFVRQNLPDFNQTTPQFWLEC-------PLNTKVLKLPDHLSTDEWVILNPQVATIFRVN 586

  Fly   575 YDERNWQLIGNAL-SGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQ 638
            |||.||:||..:| :..|:..|.:..:|||:.|::.||...:..||.|.:.|.:|:.|.:|:.||
  Fly   587 YDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLPWQ 651

  Fly   639 AADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMV--IVLQLSCR 701
            .|...|..| ..|......:.||.:|:.||...::...|..|.......|.::..  .....:||
  Fly   652 RAIGILNRL-GALLNVAEANKFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPFAHFAYSQACR 715

  Fly   702 TDLESCADFALKEFAGLTLETN---RIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERR 763
            ..:..|.|.|  :...:|..|.   .:|.|..:..||:.:..|.:|::..:..|:..|....:||
  Fly   716 YHVADCTDQA--KILAITHRTEGQLELPSDFQKVAYCSLLDEGGDAEFLEVFGLFQNSTNGSQRR 778

  Fly   764 ILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLL-------IFSAVAQNPLGYNIAKKYLVDNI 821
            ||.||:.|.|.....::.||..     :..|:.||       :.||:.:.|| .:....|::.:.
  Fly   779 ILASALGCVRNFGNFEQFLNYT-----LESDEKLLGDCYMLAVKSALNREPL-VSPTANYIISHA 837

  Fly   822 KAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISW 886
            |.:.:.:  ...||..|:..|.:.:.:.||::.|    :..|::|..||...::.|..|:.|..|
  Fly   838 KKLGEKF--KKKELTGLLLSLAQNLRSTEEIDRL----KAQLEDLKEFEEPLKKALYQGKMNQKW 896

  Fly   887 HNRQYHNLLAAV 898
            ......:.:.|:
  Fly   897 QKDCSSDFIEAI 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	87/329 (26%)
		Peptidase_M1	25..392	CDD:279741	112/386 (29%)
		GluZincin	30..480	CDD:301352	143/480 (30%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	115/412 (28%)
		M1_APN_2	37..496	CDD:189008	143/480 (30%)
		ERAP1_C	573..890	CDD:288671	88/331 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850