DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and Trhde

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	927	Identity:	256/927 - (27%)
Similarity:	422/927 - (45%)	Gaps:	83/927 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILS 69
            ||..:.|            :.:|:||||||.|...:|    :..|||||.:.:.....||.::|.
  Rat   177 PWTQLRL------------SGHLKPLHYNLMLTAFME----NFTFSGEVNVEIACQNATRYVVLH 225

  Fly    70 NNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQL-SRASG 133
            .:.:.| |.|.:......|.|.|...:.......|.:|.|..|.....|.|.:.::..: :...|
  Rat   226 ASRVAV-EKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLG 289

  Fly   134 YFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSD 198
            :|...|:..... :::.|||.:|..|...||||:...:.|.|.:::.|.....::|||.| :||.
  Rat   290 FFRSSYVIHGER-RFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSV 352

  Fly   199 HEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKI--ADQGDYAISITP 261
            .|:|.:|...|.|||.||...||::|..||.|.:. ...|..:..:.||..  ...||||:.||.
  Rat   353 FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETT-TKSGVVVRLYARPDAIRRGSGDYALHITK 416

  Fly   262 QIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVA 326
            ::|.|:...|..||...|:|.|.:|...|.:.|:.||..:.|...|.....|:......|...:.
  Rat   417 RLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIV 481

  Fly   327 QEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQAL-AVLVEDSKSS 387
            .|..|.|..||.....:   ||..|.:.|......|.:.|:|...:...:...| .|::.|..:|
  Rat   482 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLAS 546

  Fly   388 AYPMS-----LAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLW 447
            ::|:|     .....|..|..|.:|.|.|.|||.:.:|...|...|:.|| ..||..::.:..||
  Rat   547 SHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYL-TIHKYGNAARNDLW 610

  Fly   448 HTLQEESDNQMSLRQD---IKVSQLMDSWTMQPGYPLIRVVRNYDT-NEVTVTQERFLRNPGK-- 506
            :||.|      :|:::   :.:.::||.||:|.|||:|.::.|... |.:.:||:.|:.:.|.
  Rat   611 NTLSE------ALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIYDIGAKT 669

  Fly   507 ---LMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDK--WVVFNLR 566
               .:|.....|.:|||. ..|..|.||:....|::.:...       :.:...||  |::.|:.
  Rat   670 KALQLQNSSYLWQIPLTI-VVGNRSHVSSEAIIWVSNKSEH-------HRITYLDKGSWILGNIN 726

  Fly   567 LATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNE 631
            .....|:.||.|||:|:.:.|. .|...:....||.||.|..:||.||.:..::.|..:.:|..|
  Rat   727 QTGYFRVNYDLRNWRLLIDQLI-RNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEE 790

  Fly   632 DEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANIT------- 689
            .:|:.|.||...|..|.:.|.:....:.|..::...:.|.:.:|    |....|.|.:
  Rat   791 KDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKL----GWPKNNFNGSVVQASYQ 851

  Fly   690 --ELMVIVLQLSCRTDLESC---ADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLL 749
              ||...|:.|:|....:.|   |...:.::  ::...||||:::.:.:|||.:....|..|..:
  Rat   852 HEELRREVIMLACSFGNKHCHQQASTLISDW--ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFI 914

  Fly   750 RRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAK 814
            ...:..:....|::|||.|:.||.:...|.:||||:.....:...|.:.:...||:||.|.::|.
  Rat   915 WMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAW 979

  Fly   815 KYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIA-FRRILE 878
            |:..|..|.:...||......::|::.:.:.:.||.||..|:.||:    :..|...| |.|.:|
  Rat   980 KFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMK----SYDGVASASFSRAVE 1040

  Fly   879 LGEDNISWHNRQYHNLL 895
            ..|.|:.| .|.|.:.|
  Rat  1041 TVEANVRW-KRLYQDEL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	87/329 (26%)
		Peptidase_M1	25..392	CDD:279741	108/373 (29%)
		GluZincin	30..480	CDD:301352	135/464 (29%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	132/459 (29%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	89/334 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349252
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940