DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG40470

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	223/935 - (23%)
Similarity:	386/935 - (41%)	Gaps:	154/935 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LIVLHLCLPIGGTGATASNLRPLHY--NLSLLTEVEPLKL---------SGNFSGEVIIRLRVW- 60
            |.:|.:.|...|..|..::...||.  .:.|..||.||..         :.||.|.:.:.|| |
  Fly    23 LFILTILLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLR-WI 86

  Fly    61 ----------RETRTIILSN---NGLQVGE-----NVLLVRRNTGGRVTVRKMWQASSVHQLGIV 107
                      .:|..|.:|.   ..|.:|:     ||:::|   |.|:..:.::
  Fly    87 GDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILR---GVRLPRKPVF----------- 137

  Fly   108 FNSMLWL------GEEYTLVVQFSGQLSRA-SGYFVGGYMDSKHHPQWI-AVTQLAPNLANTVFP 164
               :|:|      |.|..|.:.|.|.:|.. .|.|...|.:|.:..:.| ..|.|.||.|..:||
  Fly   138 ---VLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFP 199

  Fly   165 CFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEK-DDYVWTTFQQTPAMSVQKLAFSINRFT 228
            ||:......||.:::|.|:|...:.|..:..|.:|.| ..|....|..|..||.....|.|.:..
  Fly   200 CFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLH 264

  Fly   229 NRTSAEIPKG---PALTTWLR----PKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLP 286
            .....:|.|.   ||:..|..    ..:.|..: .:::....|..|   |..|.|..|:|.:.:|
  Fly   265 MWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQN-KLNVAHTTIQHF---FNIPLPLTKLDVIAIP 325

  Fly   287 DTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALYW----LHN 347
            .        |..:.:..|:.:..|:.|....|.  ...:::|..:.|:. :.....:|    ::.
  Fly   326 S--------LATLPFISASGILIARESEILKKD--VFEISRELIYQWIG-IWITPEWWTDANVNK 379

  Fly   348 GLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYA-----SKSSDTQ---- 403
            .|..:::...|..:.....|                  :..|||::.|:     ||.....
  Fly   380 ALISFIASEIVFEINGGIEF------------------NGKYPMTILYSLYYELSKRYPNSHITG 426

  Fly   404 -----ANQKSALLFRMLHSLIGTQAFLNALRLYLQR---SHKGSSSNQAFLWH--TLQEESDNQM 458
                 |:.|..|:.|||...:|...|    ||.:|.   .:|..:...:..|:  |.|.::||
  Fly   427 IKHEFASIKVQLIIRMLSLTVGKYTF----RLGIQSFICDYKFKTYKSSDFWNAITTQAKADN-- 485

  Fly   459 SLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQ---CWWVPLT 520
            ||..|:.:..:.:||......||:.::|:||:....|.|:.:||.  :|.....|   .||:|:.
  Fly   486 SLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRE--RLHDVPDQDNMLWWIPIA 548

  Fly   521 FATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGN 585
            .......|||:|...:|:. :.||    ::::.:...:.:::.|.....|..:.||:.||.::..
  Fly   549 LKRQDSLSFVNTGSFKWMN-KTRQ----MLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSK 608

  Fly   586 AL-SGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHR 649
            .| :.....||..:|||:|:.|..|||.||.:.:..|||....|:.|...|||....|:|:.:.:
  Fly   609 YLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGK 673

  Fly   650 TLRQTTIISTFKGFMRDLLQTKFDELFKRDGSA--AENANITELMVIVLQLSCRTDLESCADFAL 712
            .|.:::|...|:.::.:||...::.|    |:|  .|:.|||||..:.....|:.....|...|.
  Fly   674 RLEKSSINKKFELYIIELLAPLYEYL----GTAHFNEDINITELRKLTTSFLCKAGYFPCFKEAR 734

  Fly   713 KEF---AGLTLETNRIPVDLSETIYCTAIQFGTEADWTL-LRRL--YTRSNVSEERRILLSAMA- 770
            :.|   ...:......||. :|.| |:..::|:..:|.. |.||  :.:|.:..:|..||..:|
  Fly   735 RAFNIWINSSFPNFETPVP-NEYI-CSIFKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAG 797

  Fly   771 CSRENWALDKLLNLAFAGR--YMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTD 833
            |..:...:..||.||....  .....|.:||.|.|....:||.....:|.:|...|...:.:||:
  Fly   798 CPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTN 862

  Fly   834 ELAQLVTVLMKEVTTEEELNALRMF 858
            ...:|::......:|:|..:.::.|
  Fly   863 IWTKLISSATGMFSTQEGYDLVKKF 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	83/310 (27%)
		Peptidase_M1	25..392	CDD:279741	88/416 (21%)
		GluZincin	30..480	CDD:301352	114/518 (22%)
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	108/499 (22%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	83/310 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920