DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG31445

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	301/936 - (32%)
Similarity:	484/936 - (51%)	Gaps:	66/936 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPWYLIVLHLCLPIGGTGATASN------------LRPLHYNLSLLTEVE-PLKLSGNFSGEVII 55
            :.|:|:.:   |.||...:.|::            |||..|.|.:||.:| |..|  .|:|.|.|
  Fly     1 MKWFLLFV---LAIGLDLSVANSISRYNHYRLPTALRPQRYYLRILTLLESPDDL--RFAGNVQI 60

  Fly    56 RLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSV------------HQLGIVF 108
            .::..:.||.|.|.:..|.:.|:          |:|:|::..|.::            |.. .:|
  Fly    61 VIKALQNTRNITLHSKNLTIDES----------RITLRQISGAGNMDNCVSSTSVNPTHDY-YIF 114

  Fly   109 NSM--LWLGEEYTLVVQFSGQLS-RASGYFVGGYMDS-KHHPQWIAVTQLAPNLANTVFPCFENR 169
            ::.  |..|..|.|.:.||..|: :..||:...|.|. .:..:|::.||..|:.|...||||:..
  Fly   115 HTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEP 179

  Fly   170 TFLAPFILNLAHPRGTNAVSNMRVLKTSDHEK-DDYVWTTFQQTPAMSVQKLAFSINRFTNRTSA 233
            .|.|.|::.|.:.:..||:|||.|.:...||. .:|:|..||::..||...:|:|:|.|:.:.|.
  Fly   180 GFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPST 244

  Fly   234 EIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGL 298
             :|.|....||.||...||.|||....|:::.::...||..||..||||:.:||.:..:.|:.||
  Fly   245 -LPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGL 308

  Fly   299 VSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDN 360
            |.|.|:..|||...|:...||.:|:.:|.|.||.|..:|.....:   ||:.|.:.||:|..|..
  Fly   309 VKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQE 373

  Fly   361 VEPAWRFHELSMVRQALAVLVEDSKSSAYPMS-----LAYASKSSDTQANQKSALLFRMLHSLIG 420
            :.|.|...:...:...:.....||..|::|:|     :....:|.|..:.||.:.:.||:|..:|
  Fly   374 IYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMG 438

  Fly   421 TQAFLNALRLYLQ-RSHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRV 484
            .::|...||.||: .::|.:..|.  ||.:|...:....:|.....::.:|||||:|.|:|::.:
  Fly   439 EESFRTGLREYLKLYAYKNAEQNN--LWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNI 501

  Fly   485 VRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPL 549
            .|:|.|....:||||:|||.......|..||||||::.|...:.|.:|.|..|:.|.......|.
  Fly   502 TRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPT 566

  Fly   550 ILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAG 614
            .::..|.|::|::.|::|:||.:..||.|||:|:.:.|:..:..||....|||||.|||..|..|
  Fly   567 TIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTG 631

  Fly   615 VVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRD 679
            ...|:.||....:||.|.:.|.|::|...|:.|:|.||||....:||.:|:.||...::.|...:
  Fly   632 EQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMN 696

  Fly   680 GSAAENANITELMV--IVLQLSCRTDLESCADFALKEFAGLTLETN-----RIPVDLSETIYCTA 737
            .:.:......|:::  .|:.::|:.|:..|...|...|.....|||     .:|::|..|:||||
  Fly   697 DTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTA 761

  Fly   738 IQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGR-YMPKDDVLLIFS 801
            |..|||.||..|...|.:|||:.||:.:||.:.||:|.|.|.:.:..:|..: .:.|.|..|.|.
  Fly   762 ISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQ 826

  Fly   802 AVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNL 866
            |||...:|:.:||:|.::|::.|.|.|...|..:::|:|.|.::|:|..:||..|.|.......|
  Fly   827 AVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFL 891

  Fly   867 PGFEIAFRRILELGEDNISWHNRQYH 892
            .|...|.::.||....|:.|.:..||
  Fly   892 KGIRQAMQQSLETMLTNVQWMDWNYH 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	111/324 (34%)
		Peptidase_M1	25..392	CDD:279741	123/399 (31%)
		GluZincin	30..480	CDD:301352	147/476 (31%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	127/411 (31%)
		M1_APN_2	43..497	CDD:189008	145/469 (31%)
		ERAP1_C	578..904	CDD:288671	112/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449993
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850