DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG31343

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	875	Identity:	220/875 - (25%)
Similarity:	383/875 - (43%)	Gaps:	81/875 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TASNLR------PLHYNLSLLTEVEPLKLSGN--FSGEVIIRLRVWRETRTIILSNNGLQVGENV 79
            :|.|.|      |..||:.|.|.|.    :|:  |:|.|.|.:||..||..|.|........|..
  Fly    52 SAGNYRLPNTTEPESYNVELWTNVH----NGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEAT 112

  Fly    80 LL---VRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSG-QLSRASGYFVGGYM 140
            ::   |...|...:||....|...:................:|:.:.::| ..|...|:::..|.
  Fly   113 IISRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYT 177

  Fly   141 DSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRV--LKTSDHEKDD 203
            |......::|.||.....|...|||::.....|.|.:.:.|.....|:|||.|  ..||...
  Fly   178 DDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGV--- 239

  Fly   204 YVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFI 268
               |.||.||.||...:||.::.|.: |:.|: .|.....:.|....||.::|:.....:.....
  Fly   240 ---TAFQTTPKMSTYLVAFIVSDFES-TTGEL-NGIRQRVFSRKGKQDQQEWALWSGLLVESSLA 299

  Fly   269 SLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHW 333
            |.||.|:...|:||..:||.:..:.|:.||.:|.|....::.|.||...|..:|:.:..|:||.|
  Fly   300 SYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMW 364

  Fly   334 LSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAY 395
            ..||.:...:   ||..|.:...|..:.|...|.|..:::..|....:.|:.|:.:||.||: .|
  Fly   365 FGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMT-HY 428

  Fly   396 ASKSSD------TQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEES 454
            ....|:      |.:..|.|.:..|..:....:.|...|..||.: ::.:|.::..|:.:.||.:
  Fly   429 VQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTK-NQYTSCDEWDLFASFQESA 492

  Fly   455 DNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPL 519
            | ::.......|..:..||:.|.||||:.|.|||:...:|:||:|::.|.   .......|:|||
  Fly   493 D-ELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANK---TDTNSATWYVPL 553

  Fly   520 TFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEV-AQPDKWVVFNLRLATPCRITYDERNWQLI 583
            .||||....:..|..:.:|.     ..:..::::| |..|.|::.|::.:...|..||.:|:.||
  Fly   554 NFATANKYDYRDTSATHYLL-----NVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLI 613

  Fly   584 GNALSGTNASSIDRF---TRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLE 645
            ..||.    |...||   .||||:.|.........:::.:.|..||:|.||.::..|..|:|.|.
  Fly   614 TAALK----SQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILT 674

  Fly   646 WLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVIVLQLSCRTDLESCADF 710
            ...|.||.......|:.|::.|:...||::...:.......| ..|.::::.|:|:...:.|.:.
  Fly   675 VYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLN-NYLRIVLVSLACQVGSDDCYNQ 738

  Fly   711 ALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRE- 774
            :..:.:........|...|....||..::..|...::.::.....|:.|.:|.:.:|::.||..
  Fly   739 SANKLSEYLYNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGST 803

  Fly   775 -------NWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNT 832
                   ..:||...:|:::.|      ..|:.||.:::.:|...:.::|..|.:|.     :|.
  Fly   804 SQLLDFLRLSLDTNNSLSYSER------TSLLNSAYSRSEIGLTASLEFLESNWEAY-----ANL 857

  Fly   833 DELAQLVTVLMKEVTT-------EEELNAL 855
            .:.|:.:...::.:.|       :..||||
  Fly   858 SDSAKPLDAALRGIATYVVSEKQKTRLNAL 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	69/313 (22%)
		Peptidase_M1	25..392	CDD:279741	103/383 (27%)
		GluZincin	30..480	CDD:301352	121/466 (26%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	106/401 (26%)
		M1_APN_2	65..517	CDD:189008	121/466 (26%)
		ERAP1_C	591..886	CDD:288671	66/310 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850