DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and anpepb

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001082794.1	Gene:	anpepb / 322533	ZFINID:	ZDB-GENE-030131-1253	Length:	965	Species:	Danio rerio

Alignment Length:	917	Identity:	249/917 - (27%)
Similarity:	415/917 - (45%)	Gaps:	109/917 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRPLHYNLSLLTEVEPLKLSGN------FSGEVIIRLRVWRETRTIILSNNGLQVGENVLL--VR 83
            |.|..|.::|..     :|..|      |:|:..:..|....|..|::.:|.|.:.::..|  :.
Zfish    83 LSPETYKVTLWP-----RLQKNAEGLYIFTGDSSVVFRCVENTDLILIHSNKLTIKDSTTLKALG 142

  Fly    84 RNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMDSKHHPQ 147
            .|....:...||:  .....:.|..:..|..||.|.|..:|.|:|| ...|::...|.|.....:
Zfish   143 GNPAPNIVSTKMY--PKTQYMAIWLDRELTAGESYELYTEFVGELSDDLGGFYRSEYYDENGVLK 205

  Fly   148 WIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKD--DYVWTTFQ 210
            .:|.||:....|...||||:.....|.|.:.|.|..||.|:||..|::......|  ....|||.
Zfish   206 VVATTQMQATDARKAFPCFDEPAMKAVFNIVLLHDPGTVALSNGVVIEEIPVTVDGISLTKTTFA 270

  Fly   211 QTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKI---------------ADQGDYAISIT 260
            .|..||...|||.::.|               |::..|:               |:||:||:|:|
Zfish   271 PTEKMSTYLLAFIVSEF---------------TYIEQKLDDLQIRIFARKEAIDANQGEYALSVT 320

  Fly   261 PQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHV 325
            .:|:.||...:...||..|.||:.|||....:.|:.||::|.|.|.||..:.|:...|::|.:.:
Zfish   321 GKILRFFEEYYNSSYPLPKSDQIALPDFNAGAMENWGLITYRETALLYDEEMSSNGNKERVVTVI 385

  Fly   326 AQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSS 387
            |.|.||.|..:|.....:   ||:.|.:.||.....|..||.|...:|.::.....|...|:.:|
Zfish   386 AHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADEAEPLWNIKDLIVLNDVHRVFAIDALAS 450

  Fly   388 AYPMSLAYASKSSDTQ------------ANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSS 440
            ::|:|    ||..|.|            :..|.|.:.|||.:.:....|...||.||:. .|.::
Zfish   451 SHPLS----SKEEDVQRPEQISEVFDTISYSKGASVLRMLSNFLSEDVFTQGLRTYLEH-FKFNN 510

  Fly   441 SNQAFLWHTLQ---EESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVT--VTQERF 500
            :....||..||   :|:..::..    .|..:||.|.:|.|:|::.:      |.||  ::||.|
Zfish   511 TVYTDLWDHLQMAVDETGTELPR----SVKDIMDRWVLQMGFPVVTI------NTVTGQISQEHF 565

  Fly   501 LRNPGKLMQKRQ--QCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEV-AQPDKWVV 562
            |.:|....:..:  ..|:||:|:.     ...:..|..||..:..|      .::: ...::||:
Zfish   566 LLDPETKPEPSEFNYEWFVPITWT-----KNEAIKPQYWLLQKNTQ------FDDMKTNANEWVL 619

  Fly   563 FNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGH 627
            .|:......|:.|||:||:.:.|||. |:..||....|||||.|..|||.||::...|||.....
Zfish   620 ANINTVGYYRVNYDEQNWERLLNALQ-TSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEF 683

  Fly   628 LRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFD---ELFKRDGSAAENANIT 689
            |..|.|::.||:|...|::.:....::.:....:.::|..:...|:   ||....| ..:|....
Zfish   684 LDVETEYMPWQSALNNLDYFYLMFDRSEVYGHMQAYIRKQVTPLFEYFTELTDWQG-VPDNHTEQ 747

  Fly   690 ELMVIVLQLSCRTDLESCADFALKEFAGL--TLETNRIPVDLSETIYCTAIQFGTEADWTLLRRL 752
            ...|..|:::|...|::|.|.....|...  ..:.|.|..:|..|:||:||..|...:|....::
Zfish   748 YNQVNALRVACSIGLKNCTDLVTSWFGEWMNNEDVNPIHANLRSTVYCSAIAAGGAEEWEFAWKM 812

  Fly   753 YTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYL 817
            :.:::|:.|:..|.:||||:.:.|.|::.|........:.|.|......::|.|..|.::|..::
Zfish   813 FEKTSVASEKDKLRAAMACATQPWLLNRYLEYTLDANKIRKQDATSTIVSIASNVGGQSLAWDFV 877

  Fly   818 VDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF---EIAFRRILEL 879
            ..|.:.|...||..:...:.|:..:.|..:||.||..|..| :.|.::: ||   .:|.::.:|.
Zfish   878 RANWEYIFNQYGGGSFSFSNLINGVTKRFSTEFELKQLMQF-KEDNEHI-GFGSGSLAIQQSIER 940

  Fly   880 GEDNISW 886
            .:.||.|
Zfish   941 TKANIKW 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	90/324 (28%)
		Peptidase_M1	25..392	CDD:279741	110/393 (28%)
		GluZincin	30..480	CDD:301352	135/493 (27%)
anpepb	NP_001082794.1	Peptidase_M1	78..479	CDD:279741	115/421 (27%)
		M1_APN_2	88..549	CDD:189008	135/491 (27%)
		ERAP1_C	618..940	CDD:288671	90/325 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040