DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and CG31198

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	234/964 - (24%)
Similarity:	407/964 - (42%)	Gaps:	150/964 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTG--------------AT-------ASNLRPLHYNLSLLTEVEPLKLSGN 48
            |...::|..|:.:...|              ||       |.::.|::||::|...:  |:..||
  Fly     4 PRVAVLLVACVSLASAGTRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYL--LETDGN 66

  Fly    49 ----FSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMWQA-------SSVH 102
                |.||      ||.|    ::||   |...::.|..:|.  ..:||:.||.       .:|.
  Fly    67 KRFTFDGE------VWIE----VISN---QTTNDIYLHSKNL--TYSVREYWQKPTTEVANPTVI 116

  Fly   103 QLG-------------IVFNSMLWLGEEYTLVVQFSGQL-SRASGYFVGGYMDSKHHPQWIAVTQ 153
            |:.             :..::.|.....|.|...::|.: ....|::...|:|..:..:|:..||
  Fly   117 QISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQ 181

  Fly   154 LAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWTTFQQTPAMSVQ 218
            ...:.|...||.|:...|.|.|.:.|...|..|:|||.|::.:....::......::.||.||..
  Fly   182 FQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTY 246

  Fly   219 KLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAM---KI 280
            .|||.|:.|..|      |......:.||:...|..|..::..||:........|.|.:|   |:
  Fly   247 LLAFIISEFVAR------KDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKM 305

  Fly   281 DQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY-- 343
            |...:||.:..:.|:.||::|.|.:.|.....:|..::|.:|:.||.|.||.|..||.....:
  Fly   306 DMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSY 370

  Fly   344 -WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMS------LAYASKSSD 401
             ||:.|.:.|...|....||..|...:..:|.|..:|:..||.::..|:|      .|:.|:..:
  Fly   371 TWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFN 435

  Fly   402 TQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFL--WHTLQEESDNQMSLRQDI 464
            :.:..|.|...||:...:|.|.|..:|:.||::....||..:..|  |......|....|.:...
  Fly   436 SISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESSKDIF 500

  Fly   465 KVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFL--RNPGKLMQKRQQCWWVPLTFATAGID 527
            |      |:|.|.|||||.|  ....::|:.||:|||  .:.|.....:   :.||:::.|:..:
  Fly   501 K------SFTEQVGYPLINV--TVGNSQVSFTQKRFLLKESDGSDSSLK---YTVPISYTTSETN 554

  Fly   528 SFVSTLPSEWL------TCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNA 586
            :|::|.|...|      |.|...|.            ||:|.|::.....|:||.:.||..|.:|
  Fly   555 NFLNTTPKFILKPNVTTTVQFNSTI------------KWIVVNIQQTGYYRVTYSDDNWHAIHHA 607

  Fly   587 LSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTL 651
            |...|...|....|||::.|:.|||.||.|||:|.|:.:.:|:.|..:|.|.:|.....:|  |:
  Fly   608 LITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL--TI 670

  Fly   652 RQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVI----VLQLSCRTDLESCADFAL 712
            |.....:.|..:::.|....:::|     ...|.:|.|.|.:.    :|..:||.....|...|.
  Fly   671 RLGNDTADFNYYIQTLTNKAYNQL-----GFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQ 730

  Fly   713 KEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWA 777
            ..|..|.    .:|.::..|:||..::.|.||::..|...:....|:.|..:|.::..|.:....
  Fly   731 GYFQSLA----TVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSL 791

  Fly   778 LDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQ----- 837
            ::|:.:|..:.....:|...::.:...:|.           :|:..:..|.....:|||:
  Fly   792 IEKVFDLIISDEIRRQDKSSVLATLYTENN-----------ENVSPVFALVTQKYEELAEAMGGY 845

  Fly   838 -----LVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISW 886
                 :::.:....||.::|..|..|.:.:.......:..........::|:.|
  Fly   846 SAVATVISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEW 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	74/330 (22%)
		Peptidase_M1	25..392	CDD:279741	103/397 (26%)
		GluZincin	30..480	CDD:301352	126/488 (26%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	107/422 (25%)
		M1_APN_2	50..510	CDD:189008	126/488 (26%)
		ERAP1_C	582..898	CDD:288671	75/337 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920