DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and Aopep

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_008769651.1	Gene:	Aopep / 290963	RGDID:	1309592	Length:	886	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	124/600 - (20%)
Similarity:	199/600 - (33%)	Gaps:	186/600 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 TQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHE------KDDYVWTTFQ 210
            |..:|.....:|||.|      |.:..........|.::..||.:.:..      ::.|:...:.
  Rat   335 TMGSPINNRALFPCQE------PPVAMSTWQATVRAAASFVVLMSGEKSAKPTPLREGYMSWHYY 393

  Fly   211 QTPAMSVQKLAFSINRFTNRTSAEIPKGPAL------TTWLRPKIAD--------QGDY------ 255
            .|..|.......::..:|...    ||...|      |..|||..||        ..:|
  Rat   394 VTMPMPASTFTIAVGCWTEMK----PKTSPLDDLTEHTLPLRPSDADFRYGNTCSHMEYPCRFQS 454

  Fly   256 AISITPQIIVFFI--------------------------SLFGKPYPAMKIDQLVLPDTAYQSHE 294
            |.:.|..||.:.:                          |:.| .:|..::|.|::| |.:.|
  Rat   455 ASAATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLG-THPFSRLDILIVP-TNFPS-- 515

  Fly   295 HLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALYWLHNGLSDYVSGFAVD 359
             ||:.| |...||  :|.:.|.......:.:..|.||.|.. |...|..|....||:   |||..
  Rat   516 -LGMAS-PHIIFL--SQSTLTGTSHLCGTRLCHEIAHAWFG-LAIGARDWTEEWLSE---GFATH 572

  Fly   360 NVEPAW---------------------RFH----ELSMVRQALAVLVEDSKSSAYPMSLAYASKS 399
            ..:..|                     |:|    ||....:.:.||..:.:.:.: :|.:.||..
  Rat   573 LEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEKTGH-VSASGASVV 636

  Fly   400 SDTQANQKSAL---------LFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESD 455
            .:....:|..:         |.|.|...:|.:.:...||.::...|.....:|.||...|:...:
  Rat   637 KNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLFHGQLILSQDFLQMLLESIPE 701

  Fly   456 NQMSLRQDIKVSQLMDSWTMQPGYP----------------LIRVVRNYDTNEVTVTQERFLRNP 504
            |:   |..:.|..::..|...||.|                |:|.|.:.....:.|.     |.|
  Rat   702 NK---RFGLSVENIVGDWLECPGIPKALQEERKAKDCSPSRLVRQVGSEVAKWIRVN-----RRP 758

  Fly   505 GKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQP-----------D 558
            ||..:::::.     .|.....|..|..|  |||..|  :|.||..|:.:.|.           .
  Rat   759 GKRQRRKREA-----AFEKLSPDQIVLLL--EWLLEQ--KTLSPQTLHRLQQTYHLQEQDAEVRH 814

  Fly   559 KWVVFNLRLATPCRI--------TYDE-----RNWQLIGNALSGTNASSIDRFTRAQ-------- 602
            :|          |.:        .||:     :..|.:|..|.|....|.|  .|.|
  Rat   815 RW----------CELVIKHKYTKAYDQVKRFLQEDQAMGIYLYGELMVSED--ARLQQLAHRCFE 867

  Fly   603 LISDVLNLAGAGVVT 617
            |:...::.|.|.|||
  Rat   868 LVKGHMDKASAQVVT 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	16/77 (21%)
		Peptidase_M1	25..392	CDD:279741	63/316 (20%)
		GluZincin	30..480	CDD:301352	84/413 (20%)
Aopep	XP_008769651.1	GluZincin	250..697	CDD:301352	77/384 (20%)
Aopep	XP_008769651.1	Leuk-A4-hydro_C	743..884	CDD:286244	36/165 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830