Protein Alignment CG9806 and ANPEP

DIOPT Version :10

• Sequence 1: NP_572643.1
• Gene: CG9806 / 31994
• FlyBaseID: FBgn0030222
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 249/911 - (27%)
• Similarity: 398/911 - (43%)
• Gaps: 87/911 - (9%)

  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGN------FSGEVIIRLRVWRETRTIILS----NNGLQVGENV 79
            :.|:|..|.::|...:.|     |      |.|...:|......|..||:.    |..|..|..|
Human    78 NTLKPDSYRVTLRPYLTP-----NDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRV 137

  Fly    80 LLVRRNTGGR--VTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMD 141
            :|  |..||.  ..:.|.........|.:.....|....:|.:..:|.|:|: ..:|::...||:
Human   138 VL--RGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYME 200

  Fly   142 SKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVW 206
            .... :.:|.||:....|...||||:.....|.|.:.|.||:...|:|||.....|....:|..|
Human   201 GNVR-KVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNW 264

  Fly   207 --TTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPK--IADQGDYAISITPQIIVFF 267
              |.|..||.||...|||.::.| :....:...|..:..|.||.  .|..||||:::|..|:.||
Human   265 NVTEFHTTPKMSTYLLAFIVSEF-DYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFF 328

  Fly   268 ISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHH 332
            ...:..|||..|.||:.|||....:.|:.|||:|.|.:.|:....|::..|::|.:.:|.|.||.
Human   329 AGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQ 393

  Fly   333 WLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSL- 393
            |..:|.....:   ||:.|.:.||.....|..||.|...:|.::.....|:..|:.:|::|:|.
Human   394 WFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTP 458

  Fly   394 -------AYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAF--LWHT 449
                   |..|:..|..:..|.|.:.|||.|.:....|...|..||   |..:..|..:  ||..
Human   459 ASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYL---HTFAYQNTIYLNLWDH 520

  Fly   450 LQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQ- 513
            |||..:|: |::....|..:|:.||:|.|:|:|.|    ||:..|::||.||.:|...:.:..:
Human   521 LQEAVNNR-SIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFLLDPDSNVTRPSEF 580

  Fly   514 --CWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPD-------KWVVFNLRLAT 569
              .|.||:|...                 .|||.....:::..||.|       :||:.||.:..
Human   581 NYVWIVPITSIR-----------------DGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTG 628

  Fly   570 PCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEF 634
            ..|:.|||.||:.|...|. .:.|:|....|||:|:|..|||.|..|...||||....|..|.::
Human   629 YYRVNYDEENWRKIQTQLQ-RDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQY 692

  Fly   635 IVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGS----AAENANITELMVIV 695
            :.|:||.:.|.:......::.:....|.:::..:...|.. |:.:.:    ..||.......|..
Human   693 MPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIH-FRNNTNNWREIPENLMDQYSEVNA 756

  Fly   696 LQLSCRTDLESCADFALKEFAGLTLETNRIPV--DLSETIYCTAIQFGTEADWTLLRRLYTRSNV 758
            :..:|...:..|.:.....|.......|..|:  :|..|:||.||..|.|.:|......:..:.:
Human   757 ISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATL 821

  Fly   759 SEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKA 823
            ..|...|.:|:|||:|.|.|::.|:.......:.|.|......::..|.:|..:...::..|.|.
Human   822 VNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKK 886

  Fly   824 IIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF---EIAFRRILELGEDNIS 885
            :...||..:...:.|:..:.:..:||.||..|..|.:.:.:.  ||   ..|..:.||..:.||.
Human   887 LFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEET--GFGSGTRALEQALEKTKANIK 949

  Fly   886 W 886
            |
Human   950 W 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	M1_APN-Q_like	30..474	CDD:341064	135/473 (29%)
		ERAP1_C	560..878	CDD:463368	82/326 (25%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62
		Metalloprotease	69..967		249/911 (27%)
		M1_APN-Q_like	84..545	CDD:341064	136/473 (29%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		0/6 (0%)
		ERAP1_C	619..946	CDD:463368	84/330 (25%)