DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9806 and ANPEP

DIOPT Version :9

Sequence 1:NP_572643.1 Gene:CG9806 / 31994 FlyBaseID:FBgn0030222 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_001141.2 Gene:ANPEP / 290 HGNCID:500 Length:967 Species:Homo sapiens


Alignment Length:911 Identity:249/911 - (27%)
Similarity:398/911 - (43%) Gaps:87/911 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGN------FSGEVIIRLRVWRETRTIILS----NNGLQVGENV 79
            :.|:|..|.::|...:.|     |      |.|...:|......|..||:.    |..|..|..|
Human    78 NTLKPDSYRVTLRPYLTP-----NDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRV 137

  Fly    80 LLVRRNTGGR--VTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMD 141
            :|  |..||.  ..:.|.........|.:.....|....:|.:..:|.|:|: ..:|::...||:
Human   138 VL--RGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYME 200

  Fly   142 SKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVW 206
            .... :.:|.||:....|...||||:.....|.|.:.|.||:...|:|||.....|....:|..|
Human   201 GNVR-KVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNW 264

  Fly   207 --TTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPK--IADQGDYAISITPQIIVFF 267
              |.|..||.||...|||.::.| :....:...|..:..|.||.  .|..||||:::|..|:.||
Human   265 NVTEFHTTPKMSTYLLAFIVSEF-DYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFF 328

  Fly   268 ISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHH 332
            ...:..|||..|.||:.|||....:.|:.|||:|.|.:.|:....|::..|::|.:.:|.|.||.
Human   329 AGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQ 393

  Fly   333 WLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSL- 393
            |..:|.....:   ||:.|.:.||.....|..||.|...:|.::.....|:..|:.:|::|:|. 
Human   394 WFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTP 458

  Fly   394 -------AYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAF--LWHT 449
                   |..|:..|..:..|.|.:.|||.|.:....|...|..||   |..:..|..:  ||..
Human   459 ASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYL---HTFAYQNTIYLNLWDH 520

  Fly   450 LQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQ- 513
            |||..:|: |::....|..:|:.||:|.|:|:|.|    ||:..|::||.||.:|...:.:..: 
Human   521 LQEAVNNR-SIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFLLDPDSNVTRPSEF 580

  Fly   514 --CWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPD-------KWVVFNLRLAT 569
              .|.||:|...                 .|||.....:::..||.|       :||:.||.:..
Human   581 NYVWIVPITSIR-----------------DGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTG 628

  Fly   570 PCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEF 634
            ..|:.|||.||:.|...|. .:.|:|....|||:|:|..|||.|..|...||||....|..|.::
Human   629 YYRVNYDEENWRKIQTQLQ-RDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQY 692

  Fly   635 IVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGS----AAENANITELMVIV 695
            :.|:||.:.|.:......::.:....|.:::..:...|.. |:.:.:    ..||.......|..
Human   693 MPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIH-FRNNTNNWREIPENLMDQYSEVNA 756

  Fly   696 LQLSCRTDLESCADFALKEFAGLTLETNRIPV--DLSETIYCTAIQFGTEADWTLLRRLYTRSNV 758
            :..:|...:..|.:.....|.......|..|:  :|..|:||.||..|.|.:|......:..:.:
Human   757 ISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATL 821

  Fly   759 SEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKA 823
            ..|...|.:|:|||:|.|.|::.|:.......:.|.|......::..|.:|..:...::..|.|.
Human   822 VNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKK 886

  Fly   824 IIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF---EIAFRRILELGEDNIS 885
            :...||..:...:.|:..:.:..:||.||..|..|.:.:.:.  ||   ..|..:.||..:.||.
Human   887 LFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEET--GFGSGTRALEQALEKTKANIK 949

  Fly   886 W 886
            |
Human   950 W 950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9806NP_572643.1 ERAP1_C 561..878 CDD:288671 81/325 (25%)
Peptidase_M1 25..392 CDD:279741 112/386 (29%)
GluZincin 30..480 CDD:301352 139/479 (29%)
ANPEPNP_001141.2 Cytosolic Ser/Thr-rich junction 33..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..62
Metalloprotease 69..967 249/911 (27%)
M1_APN-Q_like 84..545 CDD:341064 136/473 (29%)
Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485 288..295 0/6 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:22932899 352..356 0/3 (0%)
ERAP1_C 619..946 CDD:403137 84/330 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155436
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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