DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and ape2

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	857	Identity:	207/857 - (24%)
Similarity:	371/857 - (43%)	Gaps:	110/857 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRV 90
            |::|:||:|||..::|..    .:.|:|::.|.|..::.:|.|....|::     |......|..
pombe    23 NVKPIHYDLSLYPDLETF----TYGGKVVVTLDVLEDSNSITLHGINLRI-----LTAALEWGSQ 78

  Fly    91 TVRKMWQASSV----HQLGIVFNSMLWLGEEYTLVVQFSGQLSRA-SGYFVGGYMDSKHHPQWIA 150
            ||   | ||.|    .::.:.|.|.:.......|.:.|:.::|.. .|::...|:||..:.:::|
pombe    79 TV---W-ASEVSYGDERIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDGNTKYLA 139

  Fly   151 VTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWTTFQQTPAM 215
            .||:.|..|...|||::.....|.|.:::........:|||..::  :..||......|.:|..|
pombe   140 TTQMEPTSARRAFPCWDEPALKATFTIDITAKENYTILSNMNAVE--ETVKDGLKTARFAETCRM 202

  Fly   216 SVQKLAF------SINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKP 274
            |...||:      .:..||  .....|:.| :..:..|..::||.:|..:..:.:.||..:||:|
pombe   203 STYLLAWIVAELEYVEYFT--PGKHCPRLP-VRVYTTPGFSEQGKFAAELGAKTLDFFSGVFGEP 264

  Fly   275 YPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLEN 339
            ||..|.|.:.:||....:.|:.|||:|..||.|.|...:.| ..::||..|..|.||.|..:|..
pombe   265 YPLPKCDMVAIPDFEAGAMENWGLVTYRLAAILVSEDSAAT-VIERVAEVVQHELAHQWFGNLVT 328

  Fly   340 AALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKSSD 401
            ...:   ||:.|.:.::|.|:.::..|.|:..|..:.....:.|..|:..|::|:.:..   ..|
pombe   329 MQFWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPIEVPI---MHD 390

  Fly   402 TQANQ--------KSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQM 458
            .:.||        |.:.:.||:...:|...|:..::.|:.:...|::..:. ||..|..||.
pombe   391 YEINQIFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTED-LWAALSAESG--- 451

  Fly   459 SLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFAT 523
               |||  |..|.:||.:.|||::.|....| .|:.:.|.|||.......::....:|.||...|
pombe   452 ---QDI--SSTMHNWTKKTGYPVLSVSETND-GELLIEQHRFLSTGDVKPEEDTVIYWAPLKLKT 510

  Fly   524 -----AGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQP---DKWVVFNLRLATP----CRITYD 576
                 |.:|                   ...:|::.::.   ||..:.:.:|.:.    .|:.|.
pombe   511 MKDGKAVVD-------------------EKAVLSDRSKKIKVDKEALESYKLNSEQSGIYRVNYS 556

  Fly   577 ERNWQLIGN-ALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAA 640
            ..:.:.:.. |:...:..|::  .||.||:||.:|:.||.......|:.:...::|..|:|:...
pombe   557 ADHLKKLSQIAVEKPDYLSVE--DRAGLIADVASLSRAGYGKVSSTLDLIKTWKDEPNFVVFAEM 619

  Fly   641 DTYLEWLHRTLR--QTTIISTFKGFMRDLLQTKFDEL---FKRDGSAAENANITELMVIVLQLSC 700
            ...|..:..|||  .:.||:..|..:.::..||...|   ||    |.::..|.:....|...:.
pombe   620 LARLNGIKSTLRFESSDIIAAMKKLVLEVSATKAHSLGWEFK----ANDDHIIRQFKSTVYNYAG 680

  Fly   701 RTDLESCADFALKEF-AGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRI 764
            ....:.....||.:| |..:...:.|..:|...::..||::|....|..|..:||::|....|..
pombe   681 LFGDDKVVKDALSKFDAYASGNKSAINDNLRSAVFNIAIRYGGAKSWDQLLEIYTKTNDPYVRNS 745

  Fly   765 LLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYG 829
            .|.|...:.:...:.|.|:|.. ...:.:.|:.||...::.:..|           :.|:.|...
pombe   746 CLRAFGVTEDEKYIQKTLDLTL-DPIVKEQDIYLILVTLSTHKNG-----------VLAMWKFAT 798

  Fly   830 SNTDELAQLVTV 841
            ||.|:|...:.|
pombe   799 SNWDKLLSRLPV 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	64/292 (22%)
		Peptidase_M1	25..392	CDD:279741	102/379 (27%)
		GluZincin	30..480	CDD:301352	123/471 (26%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	206/856 (24%)
		M1_APN_2	27..468	CDD:189008	123/471 (26%)
		ERAP1_C	541..857	CDD:288671	64/288 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910