DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and LVRN

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	895	Identity:	239/895 - (26%)
Similarity:	388/895 - (43%)	Gaps:	99/895 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRPLHYNLSLLTEVEPLKLSGN---FSGEVIIRLRVWRETRTIILSN-----------NGLQVGE 77
            |.||||:|.|..::.|.:|...   |:|.|.|.:|....|..::|.:           ..|..|.
Human   102 LVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGT 166

  Fly    78 NVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSR--ASGYFVGGYM 140
            .     ..|.|||.|..:|.|.....:.:..:..|..|..|.|.:.|||.:..  ..|.|:..|.
Human   167 G-----NATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYT 226

  Fly   141 DSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDD-- 203
            |.......:| :||.|..|..|||||:.....|.|.:.:.|.....|:|||.  |....||:|
Human   227 DQGERRALLA-SQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMP--KLGQSEKEDVN 288

  Fly   204 ---YVWTTFQQTPAMSVQKLAFSINRF--TNRTSAEIPKGPALTTWLRPKIADQG--DYAISITP 261
               :..|||..||.|....:||.|..:  .|||.    :|..:..|.|......|  |:|::||.
Human   289 GSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTE----RGKEIRIWARKDAIANGSADFALNITG 349

  Fly   262 QIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVA 326
            .|..|...||...|...|.|.:.||.....:.|:.||:.:.|:..|...:...|..|..::..|:
Human   350 PIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVS 414

  Fly   327 QEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHEL--------------SMVR 374
            .|..|.|..:|.....:   ||:.|.:.|.....::...|....:|:              ::|.
Human   415 HEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVT 479

  Fly   375 QALAVLVEDSKSSAYPMSLAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGS 439
            :|:|:.||:.|:|.       ..:..|.....|.|.:.|||...:....|::||:.|| ::...|
Human   480 RAVAMKVENFKTSE-------IQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYL-KTFSYS 536

  Fly   440 SSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERF-LRN 503
            ::.|..||...|...|:|.::.....:..:|||||.|.|:|:|.:  |..|.  .:.||.| |.|
Human   537 NAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITL--NVSTG--VMKQEPFYLEN 597

  Fly   504 -PGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPD-KWVVFNLR 566
             ..:.:......|.||:.:...|     :|.|..||.    |::......:|:..| .||:.||.
Human   598 IKNRTLLTSNDTWIVPILWIKNG-----TTQPLVWLD----QSSKVFPEMQVSDSDHDWVILNLN 653

  Fly   567 LATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNE 631
            :....|:.||:..|:.:...|. .:..:|....|.|||.|..:|:....:..:.||....:|..|
Human   654 MTGYYRVNYDKLGWKKLNQQLE-KDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEE 717

  Fly   632 DEFIVWQAADTYLEWLHRTLRQTT----IISTFKGFM---RDLLQTKFDELFKRDGSAAENANIT 689
            ||.|||..  ..:..:.|.|....    |.|..|.::   .:|:...:..:.:.:..|.::   .
Human   718 DEIIVWHT--VLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQD---D 777

  Fly   690 ELMVIVLQ----LSCRTDLESCADFALKEFA-GLTLETNRIPVDLSETIYCTAIQFGTEADWTLL 749
            .|.:|.|:    .:|...||.|...:.:.|| .:....|.||..:.:.:.|..|..|::.:|.:|
Human   778 YLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDIL 842

  Fly   750 RRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAK 814
            ...||.:...||:..|..||:||::.|.|::.:..|.:......::..:| ..||.:.:|..:||
Human   843 LNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNII-EVVASSEVGRYVAK 906

  Fly   815 KYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQ 864
            .:||:|.:|:.|.||  |..|..|:..:.:.|||:.::..|:.|....|:
Human   907 DFLVNNWQAVSKRYG--TQSLINLIYTIGRTVTTDLQIVELQQFFSNMLE 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	82/316 (26%)
		Peptidase_M1	25..392	CDD:279741	111/406 (27%)
		GluZincin	30..480	CDD:301352	134/491 (27%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91
		Peptidase_M1	97..506	CDD:279741	112/422 (27%)
		M1_APN_2	105..577	CDD:189008	134/491 (27%)
		Substrate binding. /evidence=ECO:0000250	379..383		0/3 (0%)
		ERAP1_C	648..951	CDD:288671	81/311 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850