DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and anp-1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	933	Identity:	231/933 - (24%)
Similarity:	393/933 - (42%)	Gaps:	112/933 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TASNLR------PLHYNLSLLTEVEPL-----KLSGNFSGEVIIRLRVWRETRTIILSNNGLQVG 76
            :||.||      |:.|.|::.|.:...     |.:..|.|:|:|.|.:.:..:.:.|::..|...
Worm    80 SASELRLPTSVSPISYQLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYT 144

  Fly    77 ENVLLVRRNT---GGRVTVRKMWQASSVHQLGIVFNSMLWLGE------EYTLVVQFSGQL-SRA 131
            |.  .:::::   .|:.....:....|.|: .|.||    |.|      ..||.|.|...| :..
Worm   145 EE--FIKKSSILVNGKSIAFTLDDKQSTHE-KIFFN----LDETVEPTTSATLKVAFGAPLRTDM 202

  Fly   132 SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKT 196
            ||.:...|.:||...:..||||:.|..|..:.|||:...:.|.:.:.:.||..|.||||....|.
Worm   203 SGLYQTTYTNSKGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSNGIEDKV 267

  Fly   197 SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITP 261
            .|.: ..::.:||:.||.||...||..|:.| ....|....|.....|.||:..:...||:....
Worm   268 EDGQ-PGFIISTFKPTPRMSSYLLAIFISEF-EYNEATTKSGVRFRVWSRPEEKNSTMYAVEAGV 330

  Fly   262 QIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVA 326
            :.:.::...:...:|..|.|.:.|||.:..:.|:.||::|.|:|.||..:..:...|::||..:|
Worm   331 KCLEYYEKYYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIA 395

  Fly   327 QEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPA-WRFHELSMVRQALAVLVEDSKSS 387
            .|.||.|..:|.....:   ||:.|.:..|.....|.:... .|..|...:....:.|..||.:|
Worm   396 HELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFTMDALWSALAADSVAS 460

  Fly   388 AYPMSLAY-----ASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLW 447
            .:|::...     ...|.|:....|...:..|:...||.:.|...:..||.| |:..:::...|.
Worm   461 THPLTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTR-HQFDNADAGNLL 524

  Fly   448 HTLQEESDNQMSLRQDIK--VSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERF-LRNPGKLMQ 509
            ..|.|:..:.:...:.:|  :|:.||.||.|.||||:...|..:|: :.|.|.|| |...||..:
Worm   525 TALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTH-IIVEQSRFKLLATGKEEE 588

  Fly   510 KRQQCWW-----VPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLAT 569
            |.....|     ||:.:...|    .|.|..:|:     :...|||:    :.||.|:.|.....
Worm   589 KYSNPVWGFKWDVPVWYQVVG----SSELEMKWM-----KRNEPLII----KSDKNVIINAESNG 640

  Fly   570 PCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEF 634
            ..|..|....|:.|...|. .|.......||.:||.|...||.||:::|.:.||.:.:|:||.|:
Worm   641 FYRAGYSSGLWKEISEMLK-ENHEQFSPQTRVRLIDDSFALARAGLLSYSIPLNLITYLKNEKEY 704

  Fly   635 IVWQAADTYLEWL---HRTLRQTTIISTFKGFMRD---------------LLQTKFDELFKRDGS 681
            :.|..|...:..|   :.:..:..|::.|...:.:               |.:.||.|:    |:
Worm   705 LPWSGAIAKIRELIDMYGSNPEKDIVNKFMIALAENAPARRSIDFVSKNYLDEKKFYEV----GA 765

  Fly   682 AAENANITELMVIVLQLSCRTDLESCADFALKEFAGLTL----------ETNRIPVDLSETIYCT 736
            |.:         |:|. ||......|....:|.|....|          |.::||.......||.
Worm   766 AQQ---------IILN-SCGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIPAPFRAESYCE 820

  Fly   737 AIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAF--AGRYMPKDDVLLI 799
            |::.|....:..:...|.......|:..|::|:.||::...|.|||..|.  .|......|...:
Worm   821 AVRNGNSDTFEKVFHWYKTERNQVEKLNLMTALTCSKDILTLKKLLLDAMKPEGSSFRLQDCAAL 885

  Fly   800 FSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQ 864
            |:.::.|....:....:|:|..:.:.|...::....:::::.::..:.|...|:.||.|.:
Worm   886 FAKISSNDATTDAMLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRGGLDQLRKFRK---- 946

  Fly   865 NLP-GFEIAFRRILELGEDNISW 886
            ..| ..|....::.|..|..::|
Worm   947 KAPKASEFGLDKMEESAEVTVTW 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	75/347 (22%)
		Peptidase_M1	25..392	CDD:279741	105/391 (27%)
		GluZincin	30..480	CDD:301352	123/475 (26%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	105/409 (26%)
		M1_APN_2	93..559	CDD:189008	123/475 (26%)
		ERAP1_C	632..964	CDD:288671	76/350 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020