DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and AC3.5

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001256214.1	Gene:	AC3.5 / 179447	WormBaseID:	WBGene00007071	Length:	1090	Species:	Caenorhabditis elegans

Alignment Length:	969	Identity:	217/969 - (22%)
Similarity:	387/969 - (39%)	Gaps:	153/969 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATASNLRPLHYNLSLLTEVEPLKLSGNFS-GEVIIRLRVWRETRTIILSNNGLQVGENVLLVR-- 83
            |...|::|:.|::||    .| |:.||.: |...::|.:...|..|:|:...::...|:..::
Worm   155 ALPKNVQPVWYDVSL----SP-KVGGNGTMGLAHVKLNIEEPTNKIVLNAKDIEFTRNLEKIQLS 214

  Fly    84 ------------------------------RNTGGRVTVRKMWQASSVHQLGI------------ 106
                                          ..|....|.......||....||
Worm   215 KEVTKRAKKSVDSGTNSTSEMPEGSGEEAMATTATTTTTESTTPVSSFVDTGIKVTNIEFDENLE 279

  Fly   107 ----VFNSMLWLGEEYTLVVQFSGQLSRASGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFE 167
                ..:..|..|....|.:.|:.::|..:|.....|.:|:...|.:..||.:.:....|||.|:
Worm   280 KVTLTLDQELKKGSTVVLKIPFTSKVSNNNGLKEYKYKNSEGKEQSMFTTQPSYSYLRHVFPSFD 344

  Fly   168 NRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWTTFQQT--PAMSVQKLAFSINRFTNR 230
            ...|.||..:.|.|.:|:..|:|..| ||.|  ..|...:|..:.  |...:..|..|   ..|.
Worm   345 QEAFKAPAAITLMHSKGSIVVANTGV-KTKD--DGDAQTSTLNKVLDPDFVIGDLVAS---EVNT 403

  Fly   231 TSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEH 295
            ||     |..:..|.||::....:.::....|.|.....:......:..:|.:.:|.....:...
Worm   404 TS-----GITIRIWTRPEVKHSTEQSLDYANQAIDAMEHILQSRLESKSLDIVAVPGFQTGNRVS 463

  Fly   296 LGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENA---ALYWLHNGLSDYVSGFA 357
            ...:..||...||:.|.:....|.::|..::...|..|...:.|.   ..:||:..|..::...|
Worm   464 PSFIVLPEEDILYNEQSNDINQKTRIARMISNRIAAQWFGGITNPEEFGTFWLNEALPRFLEVEA 528

  Fly   358 VD-----NVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKSSDTQ------ANQKSALL 411
            ::     |.:..|.:       :...:|..|:.:::.|:.:.....|:|..      ..:|.|.:
Worm   529 LEKILDINSDDLWTY-------EMEKILERDATATSQPLRVKNVFSSADIAEIDHEFIGKKGAAV 586

  Fly   412 FRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMS--LRQDIKVSQLMDSWT 474
            .||:...:|...|..|:|.::. |::.:......||.:.::....::.  ..:.:.|::.:::|.
Worm   587 LRMIQKSVGVNVFNKAIRSFVS-SYRSAYPYDDGLWKSFEKALGGKLKGWNNEPLDVAKFVNTWV 650

  Fly   475 MQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQK---RQQCWW----VPLTFATAGIDSFVST 532
            .|.|:||:. |...|...|.::|||| :|..|..::   |...:|    |||...::|....||
Worm   651 DQIGFPLVS-VEKLDDETVELSQERF-KNDHKTKEQFKFRNAKYWFNWEVPLFLKSSGPVGNVS- 712

  Fly   533 LPSEWLTCQGR---QTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASS 594
                ||....|   .|:..:.||    .|...|:        |:.|:|:.|..|...|..::...
Worm   713 ----WLHEAFRLPLNTSDSIYLN----TDSNGVY--------RVNYEEKRWNDIAKQLEKSHGKL 761

  Fly   595 IDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIIST 659
            .:| |||:|||||..||.:|.:.::.|||...:|..|...:.|..|....:.|...|....|...
Worm   762 SER-TRARLISDVFALANSGALPFETALNVTSYLPMETATVPWLIATRIFKKLTERLEGAPIQDK 825

  Fly   660 FKGFMRDLLQTKFDELFKRDGSAAEN-------ANITELMVIVL---------QLSCRTDLESCA 708
            ...|:...:..||:|:....|.|:.|       ||:.:||.||.         :|.....|..|
Worm   826 LNSFIYQKIHKKFEEISSSPGEASSNYLKNRLYANLLDLMAIVKPEKSNEKLNELFVEGFLAPC- 889

  Fly   709 DFALKEFAG-LTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACS 772
                 :|:| .:.:.:.:|.||.|.:||..::||.:..:..:|.|..:.....|:.:|.:::||.
Worm   890 -----QFSGNFSSDCSEVPGDLREKVYCNGVEFGNDTVFETVRELAEKEVDGAEKDLLQNSLACF 949

  Fly   773 RENWALDKLL--NLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDEL 835
            |:..||.:|:  ||      .....|.|:...:...|:|..||..:::||...::|....|..|.
Worm   950 RDPRALRRLILDNL------NSTSTVTLLLRKMNSRPVGKEIATNWIIDNWSTVLKKKFKNDPET 1008

  Fly   836 AQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNISWHNRQYHNL 894
            ...:......:..|.|.:.:..||....::..|.|...::|.|...| |.|..::.:.|
Worm  1009 LNAIADAGIILDNEREKSMIETFMEHHHKSTHGIESLDKKIEEATTD-IYWRKQKINEL 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	85/335 (25%)
		Peptidase_M1	25..392	CDD:279741	83/425 (20%)
		GluZincin	30..480	CDD:301352	98/516 (19%)
AC3.5	NP_001256214.1	Peptidase_M1	156..574	CDD:279741	85/440 (19%)
		GluZincin	165..656	CDD:301352	98/514 (19%)
		ERAP1_C	728..1052	CDD:288671	88/348 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28947
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030