DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and pam-1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	203/832 - (24%)
Similarity:	346/832 - (41%)	Gaps:	63/832 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVR 93
            |.|||:.|    .|.....:|.|...|.:.:...|..:.:....|.:....|:.:.....
Worm    86 PTHYNVRL----SPCLNQFSFDGHATIDVTIKEATDVLKVHAQSLLIQSVSLITQPGDAS----- 141

  Fly    94 KMWQASSVHQLGIVFNSM--LWLGEEYTLVVQFSGQLS-RASGYFVGGYMDSKHHPQWIAVTQLA 155
            |..:.|...:|.|:...:  ....::..|..:|.|:|: :..|::...|.|.....:::|.||..
Worm   142 KSLETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELNDKMRGFYRSQYKDKNGTEKFLASTQFE 206

  Fly   156 PNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLK---TSDHEKDDYVWTTFQQTPAMSV 217
            ...|...||||:...:.|.|.:.|.......|:|||.|:.   |:|.::..   .||..:|.||.
Worm   207 STYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISETPTADGKRKA---VTFATSPKMSS 268

  Fly   218 QKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQ 282
            ..:||::... ...||:...|..:..:..|...:||.|::.::.:.|.::...|...||..|.|.
Worm   269 YLVAFAVGEL-EYISAQTKSGVEMRVYTVPGKKEQGQYSLDLSVKCIDWYNEWFDIKYPLPKCDL 332

  Fly   283 LVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---W 344
            :.:||.:..:.|:.|||:|.|.|.|.....::||.|.:||..||.|.||.|..:|.....:   |
Worm   333 IAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLW 397

  Fly   345 LHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAV-LVEDSKSSAYPMSLAYASKSS-----DTQ 403
            |..|.:.::....|....|.::.. |..:...||. :..|:..:::|:.:...:.:.     |:.
Worm   398 LKEGFASFMEYMFVGANCPEFKIW-LHFLNDELASGMGLDALRNSHPIEVEIDNPNELDEIYDSI 461

  Fly   404 ANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQ 468
            ...||..:.|||...:....|...|||||:|....::..|. ||..|.|.|..        .|::
Worm   462 TYAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQD-LWTALSEASGQ--------NVNE 517

  Fly   469 LMDSWTMQPGYPLIRVVRNYDTNE--VTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVS 531
            ||..||.|.|:|:::|.:..|.|.  :||.|.||:.:.|:..:..|  |.||:|.|   :.|..|
Worm   518 LMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFISDGGEDPKNSQ--WQVPITVA---VGSSPS 577

  Fly   532 TLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSID 596
            .:.:.:|..:.:|   ...:..|| |.:||..|.......|:.|.:.....:...::......:|
Worm   578 DVKARFLLKEKQQ---EFTIEGVA-PGEWVKLNSGTTGFYRVEYSDEMLTAMLPDIASRRMPVLD 638

  Fly   597 RFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWL---HRTLRQTTIIS 658
            ||   .||:|:..|...|.|:....:........|||::||.|.|..:..|   .|.:.:.|:.|
Worm   639 RF---GLINDLSALLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREMSEDTLKS 700

  Fly   659 TFKGFMRDLLQTKFDELFKRDG---SAAENANITELMVIVLQLSCRTDLESCADFALKEFAGLTL 720
            .     :.|:...|::.....|   .|.|::....|..:|.....|...:...|...:.|.....
Worm   701 A-----KQLVVKMFEQTGAELGFAEQAGEDSQKMMLRSLVQARLARAGHQPTIDKFTQMFNDFLE 760

  Fly   721 ETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLA 785
            :...|..|:....:....::|.:..:..|..|...:...|..|..:.||:.:.|...|.:|....
Worm   761 KGTPIHPDIRLATFGVVARYGGKEGFDKLMNLRETTTFQEIERQTMVAMSQTPEESLLAQLFEYG 825

  Fly   786 FAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQ 837
            |....:...|.|.:|.......:|...|.||..::||..:..||.....|.|
Worm   826 FEKNKVRPQDQLYLFLGTGATHMGQQYAWKYFCEHIKEFLDKYGGANSSLFQ 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	60/283 (21%)
		Peptidase_M1	25..392	CDD:279741	93/372 (25%)
		GluZincin	30..480	CDD:301352	118/464 (25%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	118/464 (25%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	61/284 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020