DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	899	Identity:	207/899 - (23%)
Similarity:	346/899 - (38%)	Gaps:	112/899 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GGRVTVRKMWQASSVHQLGIVFNSM-LWLGEEYTLVVQFSGQLS--RASGYFVGGYMDSKHHPQW 148
            |..|.:..:.|..:..||.::.|:. :..|:.|.:...::|.::  ...|.:...|.|.:.:..:
Worm   149 GTVVPINSISQDDTTQQLSLITNANGVVAGQIYNIEFVYTGIINPYTDGGVYYTSYNDPQGNTHY 213

  Fly   149 IAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWT--TFQQ 211
            :..|.:.|..|..|||..:..::.|.|.:.:.:|....|:|||   ..::..|.|.:|:  ||.|
Worm   214 MIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSNM---METEPTKIDNIWSTITFPQ 275

  Fly   212 TPAMSVQKLAFSINRFTNRTSAEIPKGPALT-TWLRPKIADQGDYAISITPQIIVFFISLFGKPY 275
            ||.||...:||::..:.|  |..:.|...|| .|..|.......:|.....:.:.......|..:
Worm   276 TPKMSSYLIAFAVGPYVN--SQYVNKHNTLTRAWGWPGTEQYLQFAAQNAGECLYQLGEYTGIKF 338

  Fly   276 PAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENA 340
            |..|.|||.:|:....:.|:.||:.|......|:....|||..:..|..:..|.||.|..||...
Worm   339 PLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQWFGDLVTT 403

  Fly   341 ALYW----LHNGLSDYVSGFAVDNVEP--AWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKS 399
            | :|    |:.|.:||...|...:|.|  |.....|.::.:....|..|.:..|:|:........
Worm   404 A-WWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADVRYDAHPLVYPDGPAF 467

  Fly   400 SDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQE--ESDNQMS-LR 461
            .|...| |.|.:.|||..::|...|...:|.|||:. :.|::|...|:.||.:  :|:|.:. ..
Worm   468 DDITYN-KGASMLRMLSDVLGADVFKQGIRAYLQKM-QYSNANDFDLFSTLTDTAKSNNILDWCG 530

  Fly   462 QDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFAT-AG 525
            ..:.|:..|..:..|..:||||...|......|.:||.||.............|.:|||.|. ..
Worm   531 LPLNVTDFMQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISDLTATPWNYTWSIPLTSANLRH 595

  Fly   526 IDSFVSTLPSEWLTCQGRQTASPLILNE-VAQPDK----WVVFNLRLATPCRITYDERNWQLIGN 585
            .|.:...||.:    ||....:..|..| :.:|:|    |.:.::..||..||.||:..:..|
Worm   596 ADPYKQWLPRQ----QGCANMNENIQEERIKEPNKRAVQWELTSITSATYGRIIYDDIGFDRI-- 654

  Fly   586 ALSGTNASSIDRFTRAQLISDVLNLA----------GAGVVTYDLALNFLGHLRNEDEFI----- 635
             |.......|:...:..|::|..|..          |     |:..|:....:.|...|.
Worm   655 -LKLIKQDDINDNLKLTLLADEYNYMLREKKANRPFG-----YNRFLDLAKVIFNTQSFTNYPSY 713

  Fly   636 -VWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVIVLQLS 699
             |:..|...||.:.:..|............:...|..:::|..:|.|..:....:|   :.|..:
Worm   714 GVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLFFQNSYNQLKWQDTSIWDTDTFSE---VFLPFA 775

  Fly   700 CRTDLESCADFALKEFAGL----------TLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLY- 753
            .|.|:....:..|..||.:          |...|....:|.:.|||.|.::.........:.|:
Worm   776 VRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYCGAAKYAPATSDYFFQMLHS 840

  Fly   754 ------TRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNI 812
                  |.....:|...||..|:|::....|..|:.|.......|.    .||..:..||...::
Worm   841 YNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTSTLNPS----TIFGFLKYNPAASDV 901

  Fly   813 AKKYLVDN------------IKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNAL--------RM 857
            ...|.:.|            :.|:...:.|...| .||.|::.....|.::.:..        .|
Worm   902 LYNYFMANPQLVNSTMLDAYLDAMTYNWNSYFRE-GQLSTLMNTLTLTNDQFDIFDFYINRVSLM 965

  Fly   858 FMRTDLQNLPGFEIAFRRILELGEDNISWHNR-------QYHNLLAAVCNITGS 904
            |.......||.:...:..::.:|:  ..|...       .|:.|...| ||.||
Worm   966 FEYKSTYALPTYNWLYDNLVVIGK--TPWEKTPNIDAVFPYYKLDLQV-NIPGS 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	68/369 (18%)
		Peptidase_M1	25..392	CDD:279741	82/316 (26%)
		GluZincin	30..480	CDD:301352	105/407 (26%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008	105/407 (26%)
		ERAP1_C	640..931	CDD:314669	57/305 (19%)
		Peptidase_M1	999..1402	CDD:279741	7/19 (37%)
		ERAP1_C	1542..1839	CDD:314669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920