DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and mnp-1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_497878.1	Gene:	mnp-1 / 175564	WormBaseID:	WBGene00007139	Length:	781	Species:	Caenorhabditis elegans

Alignment Length:	772	Identity:	142/772 - (18%)
Similarity:	266/772 - (34%)	Gaps:	201/772 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPIGGTGATA------SNLRPLHYNLSL-LTEVEPLKLSGNFSGEVIIRLRVWRETRTII----- 67
            ||:..|.:.:      |..:|:||.|:: :.:|....|.|:        ::::..|:..:
Worm   157 LPVSCTPSQSPLTSDPSKFQPIHYVLNITIRDVRKPVLEGH--------MQLFASTKDQVQAISL 213

  Fly    68 --LSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSML--WLGEEYTLVVQFSGQL 128
              :..:.|:..:.:.:|..|||..:.|      |.|||:..:.:..|  .:.....|.|...|.:
Worm   214 HSVKIHNLENRDRIHVVNCNTGETICV------SRVHQIDDLIHLELAQSISSGVNLRVDIDGFI 272

  Fly   129 SRASGYFVGGYMDSK--HHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNM 191
            |..||..|...:.:.  ..||.|. :...|..|..|||.|:.....:.|.|.|.|....:|::|.
Worm   273 SADSGPHVFKQIPTAKWRVPQMIG-SVFEPTSARHVFPSFDLHNQKSTFNLCLNHGPSMSAIANS 336

  Fly   192 RV---LKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTN--------RTSAEIPKGPALTTWL 245
            .:   :.||.       .:.|::|..:..|:|:|.....||        ...|.:|:...:.. |
Worm   337 LINPNVSTSG-------ISCFEKTVPLIAQQLSFVAFEKTNPLFYNTTTMDGAYLPEIDMIFN-L 393

  Fly   246 RPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSA 310
            ..|...|.::..|...:::.......|..||..:::.:|.|..|  .|..||:::.|..|..|..
Worm   394 NAKNFKQYEWIHSEVSKVMALMSKWSGFSYPLTRLEIVVAPVQA--GHSALGVITLPAQAIAYQK 456

  Fly   311 QRSTTRAKQQVASHVAQEFAHHWLSDLENAALYWLHNGLSDYVSGFAVDNVEPAWRFH-ELSMVR 374
            ..||...       :.:|....|:..:...........|..||.          |:.: ||.:|:
Worm   457 HTSTHET-------LIKEVIGQWMEGVVTTEHTCFEKALIAYVE----------WKINEELQIVK 504

  Fly   375 QALAVLVEDSKSSAYPMSLAYASKS----------SDTQANQKSALLFRMLHSLIGTQAFLNALR 429
            :...:.|    |...|.:|...:.|          |....:.:...:|..|....|.:..:..:|
Worm   505 KTRKMEV----SKIRPRNLNETADSVRVLRQIKSQSSNLCSPRFVEVFYTLDETYGQETVIGMIR 565

  Fly   430 LYLQRSHKGSSSNQAFLWHTLQE-ESDNQMSLRQDIKVSQLMDSWTMQP----GYPLIRVVRNYD 489
            :...:.        ||...|:.: .|..:.:.....:...|:..| .:|    ..|::|.|  ..
Worm   566 VIFDKF--------AFSTATISDWASAAETATGGRPEAGALIHQW-YRPSSTISRPVLRAV--VS 619

  Fly   490 TNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFA-TAGIDSFVSTLPSEWLTCQGRQTASPLILNE 553
            :|.|            :..|..::.|.|||..: :||         ::......::.|.|.:.::
Worm   620 SNSV------------EFNQLTEETWTVPLEISGSAG---------TQLAVISEKKQAIPFVSSD 663

  Fly   554 VAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTY 618
                  :||.:....:...:.||...:..:......:...|.:       |..:.:..||.
Worm   664 ------YVVVDAGRKSHAFVVYDADTYLRLIRCFGDSRCPSKE-------IGGIFSDLGAA---- 711

  Fly   619 DLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAA 683
             |..|.|....|:|                        ::.:|...:.:.|....|     |:||
Worm   712 -LLANILPKPENQD------------------------VAKWKSVFKFMAQQNIVE-----GTAA 746

  Fly   684 ENANITELMVIVLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQF 740
                            |      |.:.|::|....:.      .|:.:.  ||.|.|
Worm   747 ----------------C------CVEHAIREMRKCSY------WDIQDV--CTKIDF 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	28/180 (16%)
		Peptidase_M1	25..392	CDD:279741	83/390 (21%)
		GluZincin	30..480	CDD:301352	95/488 (19%)
mnp-1	NP_497878.1	Peptidase_M1	172..556	CDD:279741	88/429 (21%)
		GluZincin	<294..>480	CDD:301352	44/203 (22%)
		GluZincin	<547..602	CDD:301352	9/62 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910