DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and Lnpep

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	235/940 - (25%)
Similarity:	396/940 - (42%)	Gaps:	130/940 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILS 69
            ||..|.|          .||  :.|..|.|||    .|...|..|.|.|.|.|:..::||.|||.
  Rat   162 PWAQIRL----------PTA--IIPQRYELSL----HPNLTSMTFRGSVTISLQALQDTRDIILH 210

  Fly    70 NNGLQVGENVLLVRRNTGGRVTVRKMWQASSV------------HQLGIVFNSMLWLGEEYTLVV 122
            :.|..:.              :|..|...||.            .|:.:|....|..|..|||.:
  Rat   211 STGHNIS--------------SVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKI 261

  Fly   123 QFSGQLSRA-SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTN 186
            ::|..:|.: .|::...|.|..:..:..|.||..|..|.:.||||:...|.|.||:.:.......
  Rat   262 EYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHT 326

  Fly   187 AVSNMRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIAD 251
            |:||| ..|:|...::..:...|.::..||...:||.:....| .|.:: .|..::.:..|:..|
  Rat   327 ALSNM-PKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRN-LSQDV-NGTLVSVYAVPEKID 388

  Fly   252 QGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTR 316
            |..:|:..|.:::.|:.:.|...||..|:|.:.:||....:.|:.||:::.|...||....|:..
  Rat   389 QVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVA 453

  Fly   317 AKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQAL- 377
            .::.|...:|.|.||.|..:|.....:   ||:.|.:.::..|:|:.:     |.||:.....|
  Rat   454 DRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKI-----FKELNSYEDFLD 513

  Fly   378 ---AVLVEDSKSSAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR 434
               ..:.:||.:|::|:|.:..|...     |:.:..|.|.|..||.|.:....|.:|:.||| .
  Rat   514 ARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYL-H 577

  Fly   435 SHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQER 499
            :|..::.....||.:..|.:...:    |:|  ::|.:||:|.|:||:.|.|.  ..|:.:.|||
  Rat   578 NHSYAAIQSDDLWDSFNEVTGKTL----DVK--KMMKTWTLQKGFPLVTVQRK--GTELLLQQER 634

  Fly   500 FLRNPGKLMQKRQQ------CWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLI-LNEVAQP 557
            |..:    ||...|      .|.:|:::.|.|.:.      ||:.:.......|.:| |.|..|
  Rat   635 FFPS----MQPEIQDSDTSHLWHIPISYVTDGRNY------SEYRSVSLLDKKSDVINLTEQVQ- 688

  Fly   558 DKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLAL 622
              ||..|..:.....:.|....|..:.|.|. .|...:....||.||:::..|||.|.|...:|.
  Rat   689 --WVKVNTNMTGYYIVHYAHDGWAALINQLK-RNPYVLSDKDRANLINNIFELAGLGKVPLQMAF 750

  Fly   623 NFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTII-------------STFKGFMRDLLQTKFDE 674
            :.:.:||||          |:...:...|.||.:|             |.....:..|||.:..:
  Rat   751 DLIDYLRNE----------THTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQ 805

  Fly   675 LFKRDGSAAENANITELMVIVLQLSCRTDLESCADFALKEFAGLTLE--TNRIPVDLSETIYCTA 737
            ....|..   ..::.||...:|:.:|...||:|...|.|.|.|....  |..:|.|:..|::...
  Rat   806 QTWTDEG---TPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVG 867

  Fly   738 IQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSA 802
            .:  ||..|..|..:|:......|:..:|.|:|.|.:...|..|:..:..|..:....:.||...
  Rat   868 AR--TEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRT 930

  Fly   803 VAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQ--- 864
            |.:...|:.:|..::.:|...::..:...:..:..:|.......:|:..|:.::.|.....:
  Rat   931 VGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATL 995

  Fly   865 NLPGFEIAFRRILELGEDNISWHNRQYHNL 894
            .|...:.|| .::||   ||.|..|....|
  Rat   996 QLRCVQEAF-EVIEL---NIQWMARNLKTL 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	72/334 (22%)
		Peptidase_M1	25..392	CDD:279741	101/386 (26%)
		GluZincin	30..480	CDD:301352	125/474 (26%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	107/422 (25%)
		M1_APN_2	176..617	CDD:189008	125/473 (26%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	690..1005	CDD:288671	72/331 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850