DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and Anpep

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	930	Identity:	250/930 - (26%)
Similarity:	413/930 - (44%)	Gaps:	88/930 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPIGGTGATASNLRPL--------HYNL--SLLTE-----VEPLKLSGN-----FSGEVIIRLRV 59
            || |.|.||.:...|.        .|.|  :|:.:     :.|.....|     |.|...:|...
Mouse    50 LP-GSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTC 113

  Fly    60 WRETRTIILSNNGLQV---GENVLLVRRNTGGRV-TVRKMWQASSVHQLGIVFNSMLWLGEEYTL 120
            .:.|..||:.:..|..   |.:.:::|...|... .:.|.........|.:.....|..|.:|.:
Mouse   114 NQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEM 178

  Fly   121 VVQFSGQLS-RASGYFVGGYM--DSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHP 182
            ..||.|:|: ..:|::...||  |.|   :.:|.||:....|...||||:.....|.|.:.|.:|
Mouse   179 DSQFQGELADDLAGFYRSEYMEGDVK---KVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYP 240

  Fly   183 RGTNAVSNMRVLKTSDHEKD-DYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLR 246
            ....|:|||...::..:.:| ....|.|..||.||...||:.::.|.|.:|.. ..|..:..|.|
Mouse   241 NNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVS-ANGVQIGIWAR 304

  Fly   247 PKIAD--QGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYS 309
            |...|  |||||:::|..|:.||...:...||..|.||:.|||....:.|:.|||:|.|::.::.
Mouse   305 PSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFD 369

  Fly   310 AQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELS 371
            :|.|:...|::|.:.:|.|.||.|..:|...|.:   ||:.|.:.||.....|..||.|...:|.
Mouse   370 SQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLM 434

  Fly   372 MVRQALAVLVEDSKSSAYPMSL-AYASKSS-------DTQANQKSALLFRMLHSLIGTQAFLNAL 428
            ::.....|:..|:.:|::|:|. |...|:.       |:....|.|.:.|||.|.:....|...|
Mouse   435 VLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGL 499

  Fly   429 RLYLQRSHKGSSSNQAF--LWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTN 491
            ..||   |....||..:  ||..||:..:.|.:::....|..:||.|.:|.|:|:|.|    :||
Mouse   500 SSYL---HTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV----NTN 557

  Fly   492 EVTVTQERFLRNPGKLMQKRQQ---CWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNE 553
            ...::|:.||.:....:.:..:   .|..|:.|..:|.:...      ||..:..|:|     ..
Mouse   558 TGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHY------WLDVEKNQSA-----KF 611

  Fly   554 VAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTY 618
            ....::|::.|:.:.....:.|||.||:.:.|.|. |:.|.|....|||:|.|..|||.|.::..
Mouse   612 QTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQ-TDLSVIPVINRAQIIHDSFNLASAKMIPI 675

  Fly   619 DLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRD-------LLQTKFDELF 676
            .|||:....|..|.|::.||||.:.|.:......::.:....|.:::.       ..|.:.:...
Mouse   676 TLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWV 740

  Fly   677 KRDGSAAENANITELMVIVLQLSCRTDLESCADFALKEFAG--LTLETNRIPVDLSETIYCTAIQ 739
            .|..:..|..|    .:..:..:|.:.|:.|.|..::.::.  .....|.|..:|..|:||.||.
Mouse   741 NRPPTLMEQYN----EINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIA 801

  Fly   740 FGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVA 804
            ||.|.:|......:..:.:..|...|.||:|||::.|.|::.|:......|:.|.|......::|
Mouse   802 FGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIA 866

  Fly   805 QNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF 869
            .|..|:.:...::..|.|.:.:.||..:...|.|:..:.:..::|.||..|..| :.| .:..||
Mouse   867 SNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQF-KAD-NSATGF 929

  Fly   870 EI---AFRRILELGEDNISW 886
            ..   |..:.||....||.|
Mouse   930 GTGTRALEQALEKTRANIDW 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	83/328 (25%)
		Peptidase_M1	25..392	CDD:279741	111/399 (28%)
		GluZincin	30..480	CDD:301352	138/492 (28%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		6/14 (43%)
		Metalloprotease	69..966		243/910 (27%)
		M1_APN-Q_like	84..545	CDD:341064	133/467 (28%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		0/3 (0%)
		ERAP1_C	618..945	CDD:403137	86/333 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940