DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and erap1

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_002933475.2	Gene:	erap1 / 100496768	XenbaseID:	XB-GENE-983344	Length:	932	Species:	Xenopus tropicalis

Alignment Length:	976	Identity:	234/976 - (23%)
Similarity:	421/976 - (43%)	Gaps:	160/976 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPWYLIVLHL-CLPIGGTGATAS-------------NLR------PLHYNLSLLTEVEPLKLSGN 48
            ||...:|::| |:......|.|:             |||      ||||:|.    :.|...:..
Frog    14 LPLCFVVVYLMCISFSIQPALAASKALDNAEMFPWKNLRLPTFAAPLHYDLL----IHPNLTTLT 74

  Fly    49 FSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMW--QASSVHQLGIVFNSM 111
            |||...:.:.|.::|..::|.:..|::.:..  ::|..|....::.:.  :.....|:.::....
Frog    75 FSGLTKVTVTVTQKTSFLVLHSKHLEITKTT--IKRKLGKDPVLQDLLLREHPVNEQIALLAADP 137

  Fly   112 LWLGEEYTLVVQFSGQLSR-ASGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPF 175
            |..||.||:.::::..||: ..|::...|.......:.:|.||..|..|.|.||||:...|.|.|
Frog   138 LIPGENYTIYIEYNANLSKNFRGFYKSTYKTKDGEVRVLASTQFEPTAARTAFPCFDEPAFKASF 202

  Fly   176 ILNLAHPRGTNAVSNMRVLKT--------SDHEKDDYVWTTFQQTPAMSVQKLAF------SINR 226
            .:.:......:|||||.|:||        .||         |..:..||...:||      ||::
Frog   203 SIQIRREPKHHAVSNMPVVKTVNIGGGLLEDH---------FAASVKMSTYLVAFIVSDFKSISQ 258

  Fly   227 FTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQ 291
            .||.       |..::.:..|:..||.:||:....:::.|:...|...||..|.|...:||....
Frog   259 VTNH-------GVRISVYATPEKIDQAEYALKAAVKLLDFYEDYFNISYPLPKQDLAAIPDFQSG 316

  Fly   292 SHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYV 353
            :.|:.||.:|.|:|.|:..:.||...|..|...:|.|.||.|..:|.....:   ||:.|.:.::
Frog   317 AMENWGLTTYRESALLHDPKTSTASHKLWVTMIIAHELAHQWFGNLVTMEWWNDLWLNEGFAKFM 381

  Fly   354 SGFAVDNVEPAWRFHE--LSMVRQALAVLVEDSKSSAYPMSLAYASKSS-----DTQANQKSALL 411
            ...:|....|..:..:  |....:|:.|   ||.:|::.:|....:...     |..:..|.|.:
Frog   382 EYVSVRVTYPELQVEDYFLDKCFRAMDV---DSLNSSHAVSTPVENPEEIQEMFDEVSYDKGACI 443

  Fly   412 FRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQE--ESDNQMS-----LRQD------ 463
            ..||...:|.::|...:..||:|....::.|:. ||:::.:  .||...|     .||.
Frog   444 LNMLMDYMGAESFEAGIVDYLRRYSYRNARNED-LWNSMTDVCPSDETNSGYCTKTRQTSHWSEG 507

  Fly   464 --IKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRN------PGKLMQKRQQCWWVPLT 520
              |.|..:|::||:|.|:||:.|  ......|.:.||.:|:.      .|.|       |.:|||
Frog   508 EIIDVKSMMNTWTLQKGFPLVTV--TVKGKYVYLHQEHYLKGSTDTEASGLL-------WHIPLT 563

  Fly   521 FATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGN 585
            :.|           |:..|.|.....|...:..:|:..:|:.||:.:.....:.|:...|..:..
Frog   564 YIT-----------SKSNTVQRFLLMSKTDVLVLAEEVEWIKFNVGMNGYYIVHYEGEGWDALIK 617

  Fly   586 ALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFI-VWQAADTYLEWLHR 649
            .|. .|.::|....||.||:....|...|.:..|.||:...:|:|||:.: |:|..|..:. :::
Frog   618 LLQ-ENHTAISSNDRANLINSAFQLVSIGRLPIDKALSLSLYLKNEDKIMPVFQGMDELIP-IYK 680

  Fly   650 TLRQ---TTIISTFKGFMRDLLQTKFD-ELFKRDGSAAENANITELMVIVLQLSCRTDLESCADF 710
            .:.:   ..:.|..|.::.:||:...| :.:..:||.:|..    |...:|..:|....:.|...
Frog   681 LMEKRDMQEVESQMKKYILNLLRKLIDAQSWTDEGSVSERM----LRSSLLLFACVRQYQPCVQR 741

  Fly   711 ALKEFAGLTLETN---RIPVDLSETIYCTAIQFGTEADWTLLRRLY-TRSNVSEERRILLSAMAC 771
            | :::.....|:|   .:|.|::..:|....|  |...|..|...| |..:.||:.:|.| |:|.
Frog   742 A-EQYFKRWQESNGTISLPRDVASAVYAVGAQ--TPEGWDFLFEKYKTTLSGSEKNQIEL-ALAI 802

  Fly   772 SRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELA 836
            :.....|..|:.....|.::...|:..|...|::||:||.::.::|.:|...:::.:...:..:.
Frog   803 TSLKHKLQWLMEEGMKGDHVRTQDLPHIVLYVSRNPVGYPLSWEFLKNNWGNLVQKFELGSRTVG 867

  Fly   837 QLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELG-------------EDNISWHN 888
            .:|..:.|:.:|:|.           |:.:.||   |..:.|:|             |:||.|.:
Frog   868 DMVVGITKQYSTKEW-----------LEEVTGF---FDSLKEMGSQLRCVQQARETIEENIRWMD 918

  Fly   889 R 889
            :
Frog   919 K 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	73/325 (22%)
		Peptidase_M1	25..392	CDD:279741	102/407 (25%)
		GluZincin	30..480	CDD:301352	124/491 (25%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	121/486 (25%)
erap1	XP_002933475.2	ERAP1_C	592..911	CDD:378732	76/342 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020