DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and anpep

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	909	Identity:	255/909 - (28%)
Similarity:	438/909 - (48%)	Gaps:	81/909 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWR-----------ETRTIILSNNGLQVGE-NV 79
            |.|:||::    |::|. |..|..|     |.|:|           .|..||:.:|.|...: |.
Frog    89 LSPVHYDV----ELQPF-LVKNADG-----LYVFRGKSTAFFICNDATDLIIIHSNKLNHTKFNS 143

  Fly    80 LLVRRNTGGR-VTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMDS 142
            ...:...|.. |.::..:.......|.:...:.|..|::|.|..:|.|:|: ..:|::...|::.
Frog   144 FDAKLQDGATDVALKSTFFQKDKQFLVVQAAANLVPGKQYGLYTEFVGELADDLAGFYRSEYLED 208

  Fly   143 KHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKDDYVWT 207
             ...:.||.||:....|...||||:.....|.|.:.|.:.:...|:||||.:..|...:|...||
Frog   209 -GVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKYRQPYKAMSNMREIDRSTVTEDGQQWT 272

  Fly   208 T--FQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTT----WLRPK-IAD--QGDYAISITPQI 263
            .  |.:||.||...:||.::.|    .|....|.|..|    |.|.| |.|  ||:||:|:|..|
Frog   273 VSKFDKTPKMSSYLVAFIVSEF----EAVGDPGNATVTGVQIWGRKKAIQDENQGEYALSVTKPI 333

  Fly   264 IVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQE 328
            :.||...:..|||..|.||:.|||.:..:.|:.|||:|.|.|.|:..|.|:...|::|.:.:|.|
Frog   334 LDFFAEYYRTPYPLPKSDQVALPDFSAGAMENWGLVTYRETALLFDDQVSSIGNKERVVTVIAHE 398

  Fly   329 FAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYP 390
            .||.|..:|.....:   ||:.|.:.||.....|..||.|...:|.::.....|:..|:.:|::|
Frog   399 LAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHRVMAVDALASSHP 463

  Fly   391 M--------SLAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLW 447
            :        |.:..|...|:.|..|.|.:.|||...:....|::.|..|| :..:.|::..:.||
Frog   464 LTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYL-KGFEYSNTVYSDLW 527

  Fly   448 HTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQ 512
            ..||...:||.:::..:.:..:||:|.:|.|:|::::    ||....|||:.||.:|..::.:..
Frog   528 THLQWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKI----DTATGVVTQKHFLLDPDSVVTRPS 588

  Fly   513 QC---WWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRIT 574
            ..   |.||:::..:..:..:      ||     |..|..:.:.....:.|::.||.:....|:.
Frog   589 PFDYKWKVPISYKISSKEDNI------WL-----QNESETVEDFKITGNDWLLVNLNVTGYYRVN 642

  Fly   575 YDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQA 639
            ||:.||..:.|.|. |:..:|....|||:|.|..|||.|..:|...||:...::..:.|::.|||
Frog   643 YDDNNWSRLLNQLQ-TSHQAIPVINRAQIIDDAFNLARAKQITTIQALDTTKYISADREYMPWQA 706

  Fly   640 ADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAEN--ANITE--LMVIVLQLSC 700
            |.:.|.:..:...:|.:....|.:|:..:...| |.||::.....|  .::|:  ..:..|..:|
Frog   707 ALSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLF-EYFKQETGNWTNRPVSLTDQYCEINTLSTAC 770

  Fly   701 RTDLESCADFALKEFAG--LTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERR 763
            ..|:|.|..||.:.|:.  .|.:.|.|..:|...:||||:..|.|.:|..:...:..:::::|:.
Frog   771 SYDIEDCLKFASELFSQWMATPQQNNIHPNLRTNVYCTAVAQGGEQEWNFVWDRFQLTDIAQEQD 835

  Fly   764 ILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLY 828
            .|.:|:|||:|.|.|::.|..:.....:.:.|.:...|:|..||:|.::|..::....|.:..::
Frog   836 KLRAALACSKEPWILNRFLEYSLDPTMIRRQDAVSTISSVVNNPIGQSLAWDFVRAKWKTLYSMF 900

  Fly   829 GSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF---EIAFRRILELGEDNISWHNR 889
            |.::.....|:..:.:..:||.||..|..| :.|.|| |||   ..|..:.:|..:.||:|.|:
Frog   901 GESSFSFGNLIERVTRRFSTEFELQQLLQF-KADNQN-PGFGTASQALEQAIEKTKANINWVNQ 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	90/325 (28%)
		Peptidase_M1	25..392	CDD:279741	118/398 (30%)
		GluZincin	30..480	CDD:301352	141/483 (29%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	139/478 (29%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	92/330 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110