DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and trhde

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	267/911 - (29%)
Similarity:	428/911 - (46%)	Gaps:	63/911 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILS 69
            ||    .:|.||        ::||||||||.    |.....:..|.|||.:.:.....:|.|::.
Frog   130 PW----TYLRLP--------THLRPLHYNLM----VTAFMNNFTFCGEVNVEIECLNSSRYIVVH 178

  Fly    70 NNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQL-SRASG 133
            .:.|.| |.|.:......|.|.|...:.......|.:|.|..|...:.|.|.:.:|..: :...|
Frog   179 AHRLTV-ERVQVAEDRVAGEVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAIIENELLG 242

  Fly   134 YFVGGYMDSKH-HPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTS 197
            :|...|:  .| ..:.:||||.:|..|...||||:...:.|.|.:::.|.....::|||.| :||
Frog   243 FFRSSYV--LHGERRSLAVTQFSPIHARKAFPCFDEPIYKATFKISIRHQTSYLSLSNMPV-ETS 304

  Fly   198 DHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKI--ADQGDYAISIT 260
            ..|:..:|...|.|||.||...||:::..||.: .|....|..:..:.||..  ...||||::||
Frog   305 VFEEGGWVTDHFSQTPLMSTYYLAWAVCNFTFK-EAVTQSGVVVRLYARPDAIRRGSGDYALNIT 368

  Fly   261 PQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHV 325
            .:::.|:...|..||...|:|.|.:|...|.:.|:.||..:.|...|.....|:......|...:
Frog   369 KRLLEFYEDYFRVPYSLPKLDLLAVPKHPYAAMENWGLSVFVEQRILLDPSISSISYLLDVTMVI 433

  Fly   326 AQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQAL-AVLVEDSKS 386
            ..|..|.|..||.....:   ||..||:.|......|.:.|.|...:...:...| .|::.|..:
Frog   434 VHEICHQWFGDLVTPIWWEDVWLKEGLAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLA 498

  Fly   387 SAYPMSLAYASKSSDTQ------ANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAF 445
            |::|:| ....|::|..      |.:|.|.|.|||.:.:|.:.|...|:.|| .:||..::.:..
Frog   499 SSHPVS-QEVLKATDIDRVFDWIAYKKGAALIRMLANFMGHKVFQRGLQDYL-TTHKYGNAARND 561

  Fly   446 LWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNE-VTVTQERFL-----RNP 504
            ||:||.:...|:..|   :.:.::||.||:|.|||:|.::||..|:: :|:|||.||     |..
Frog   562 LWNTLTKVLKNEGKL---LNIREVMDQWTLQMGYPVITILRNDTTDDIITITQEHFLYNIDKRTR 623

  Fly   505 GKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRLAT 569
            .|..:.:...|.:|||.| .|..|.:|.....|::.:......|.:     ....||:.||....
Frog   624 DKEFRNKSSLWQIPLTIA-VGNTSHISPQAIIWVSNKSEYHRIPSL-----DESNWVLGNLDQIG 682

  Fly   570 PCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEF 634
            ..|:.||.|||:|:.:.|. .|:..|....||.||.|..|||.||.:|.::.|..:.:|..|.:|
Frog   683 YFRVNYDVRNWRLLTDQLM-RNSEVISVSNRAALIDDAFNLARAGYLTQNIPLEIIRYLSEEKDF 746

  Fly   635 IVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDEL----FKRDGSAAENANIT-ELMVI 694
            :.|.||...|..|.:.|.:|...|.|..::...:.|.:..|    ..::|||...:..| ||...
Frog   747 LPWHAASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWPTNGQNGSAVPTSYQTEELRRE 811

  Fly   695 VLQLSCRTDLESCADFALKEFAG-LTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNV 758
            |:.|:|....:.|...|....:. ::...||||.::.:.:|||.:....|..|..:...:..|..
Frog   812 VIMLACSFGNKQCHQKAATMISDWISSNRNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTA 876

  Fly   759 SEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKA 823
            ..|::|||.|:.||.....|::||||:.....:...|.:.:...||:||.|.::|.|:..|..|.
Frog   877 VSEKKILLEALTCSDNRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 941

  Fly   824 IIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIA-FRRILELGEDNISWH 887
            :...||......::|::.:.:.:.||||||.|:.|::   |:..|..:| ..|..|..:.|:.|.
Frog   942 LNARYGEALFMNSKLISGVTEFLNTEEELNELKDFIQ---QHKGGSAVASLSRATETVDANVRWQ 1003

  Fly   888 N 888
            :
Frog  1004 H 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	97/323 (30%)
		Peptidase_M1	25..392	CDD:279741	108/374 (29%)
		GluZincin	30..480	CDD:301352	134/463 (29%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	131/458 (29%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	99/328 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020