DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and erap2

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	940	Identity:	217/940 - (23%)
Similarity:	397/940 - (42%)	Gaps:	103/940 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IKLPWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTI 66
            ::||.|::                   |:||:|.    :.|...:.:|:|.|.|.:.|...|..:
Zfish    43 VRLPNYIV-------------------PVHYHLL----IHPNLTTLSFTGSVKIEIDVKNNTNWV 84

  Fly    67 ILSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSRA 131
            :|.:..|::....:|.............:.:.....|:.|....:|..||:|.|.::|...||..
Zfish    85 VLHSKNLKIYTATVLDEHEAHLSEKTLSVLEYPLHEQIAIFSPKILTSGEKYFLYLEFGAPLSDG 149

  Fly   132 -SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLK 195
             .|::...|.......:.:|.|...|..|....|||:...|.|.:.:.:.......|:|||.:.:
Zfish   150 FHGFYKSTYRTKSGETRVLASTHFEPTSARMALPCFDEPVFKANYTVRIRRGPSHIALSNMPLEQ 214

  Fly   196 T--------SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQ 252
            |        .||         |:.:..||...|||.|..|.: .|.....|..::.:..|:...|
Zfish   215 TVEISNGLFEDH---------FEASVKMSSYLLAFIICDFKS-VSGLTATGINISIYAVPEKWHQ 269

  Fly   253 GDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRA 317
            ..||:....:::.|:...|...||..|:|.:.:||....:.|:.||.:|.|.:.||....|:...
Zfish   270 TQYALEAALRLLEFYEQYFNILYPLPKLDLIAIPDFESGAMENWGLTTYRETSLLYDPDISSASD 334

  Fly   318 KQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAV 379
            |..|...:..|.||.|..:|.....:   ||:.|.:.|:...:|:.|.|..:..: ..:......
Zfish   335 KLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNEGFARYMESVSVEAVYPELKVED-HFLDTCFGA 398

  Fly   380 LVEDSKSSAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGS 439
            :..||.:|:.|:|....|.:.     ||.:.:|.|.:..||...:..:.|.:.:..||:|....:
Zfish   399 IGRDSLNSSRPISSLAESPTQIKEMFDTVSYEKGACILHMLRHFLTDEGFQSGIIRYLRRFSYCN 463

  Fly   440 SSNQAFLWHTL----QEE---------SDNQMSLR------QDIKVSQLMDSWTMQPGYPLIRVV 485
            :.|:. ||.:|    .||         |..|.:..      :.:.:.::|::||:|.|.||:.|.
Zfish   464 ARNED-LWDSLIKTCSEEDFAAGEYCYSSAQATKNAYRFAGEHVDLKKMMNTWTLQKGIPLVTVK 527

  Fly   486 RNYDTNEVTVTQERFLR-----NPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQT 545
            |  ...::.:.|||||:     :|.....:....|.:|||:.|:..|..|..:..        :.
Zfish   528 R--QGRKLHIGQERFLKIVLPDDPSWHSLQDGYLWHIPLTYKTSHSDHEVKHILD--------KK 582

  Fly   546 ASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNL 610
            :..|:|:|...   ||..|..:.....:.|||..|..:...|. .|.:::....||.||.:...|
Zfish   583 SDVLLLDEHVD---WVKLNTDMNGYYIVHYDEEGWNALTELLK-VNHTALSFKDRASLIHNAFQL 643

  Fly   611 AGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDEL 675
            ..||.::.|.||:.:.:|::|...:.......||:..::.:.:..|..........:||...|.:
Zfish   644 VTAGRLSLDRALDLIAYLKSETHNVPLLQGLGYLQSFYKLIEKRKIADVTHNLKTYILQYFKDVI 708

  Fly   676 FKRDGSAAENANITELMVIVLQLSCRTDLESCADFALKEFAGLTLE--TNRIPVDLSETIYCTAI 738
            .|:..|.....:...|...||.|:|..|...|.:.|.:.|......  |..:|.|:|||:|....
Zfish   709 DKQSWSDDGMVSDRRLREDVLSLACDLDYPPCLEKAERLFVSWVKSNGTISLPTDVSETVYMVGA 773

  Fly   739 QFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAV 803
            |  .::.|..|.|.|..|....|:...|||:..|:::..|.:||.|...|..:...::..:...|
Zfish   774 Q--DDSGWVYLLRQYGVSMCETEKSKFLSALTSSKDSEKLSRLLQLGMEGTVIKTQNLPSLIYMV 836

  Fly   804 AQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPG 868
            |:||:|:.:|..::..:...:::.:...:..:.:::...:.:.::.|||..:..|.:: :|.
Zfish   837 ARNPVGHFLAWDFVKKHWNELVEKFPLGSFGIREIIVGTVTQFSSTEELREVESFFKS-IQE--- 897

  Fly   869 FEIAFRRILELG----EDNISWHNRQYHNL 894
             :::..||:::.    |.||.|..|....:
Zfish   898 -QVSQLRIIQVATENVEKNIVWLKRNLETM 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	73/318 (23%)
		Peptidase_M1	25..392	CDD:279741	90/378 (24%)
		GluZincin	30..480	CDD:301352	114/485 (24%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	97/421 (23%)
		M1_APN_2	52..522	CDD:189008	114/485 (24%)
		ERAP1_C	595..911	CDD:288671	73/323 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590503
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950