DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	903	Identity:	250/903 - (27%)
Similarity:	415/903 - (45%)	Gaps:	79/903 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRPLHYNLSLLTEVEP----LKLSGNFSGEVIIRLRVWRETRTIILSNNGLQV----GENVLLVR 83
            |.|.:||::|...::|    |.:   |:|...:..:..|||..||:..|.|.:    |....|..
Zfish    52 LFPHYYNITLWPRLQPDDHGLYV---FTGNSSVVFKCLRETDIIIIHCNKLNLTSEDGYLAKLSA 113

  Fly    84 RNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLS-RASGYFVGGYMDSKHHPQ 147
            .:|....:|:|.|.......|.:..|..|..||.|.|..:|.|:|: ..:|.:...| |.....:
Zfish   114 FSTSEVPSVKKTWIEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEY-DEDGEKK 177

  Fly   148 WIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKD--DYVWTTFQ 210
            .:|.:|:.|..|...||||:.....|.|.:.|.|.|||.|:||...::..|...|  ....|||:
Zfish   178 IVATSQMHPTHARKTFPCFDEPAMKAVFHITLIHDRGTVALSNGMEIENVDTIVDGQPVTVTTFE 242

  Fly   211 QTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIAD--QGDYAISITPQIIVFFISLFGK 273
            .|..||...||..::.:||.|||:   |..:..|.|.|..:  .||||::||..|:.||.:.:..
Zfish   243 PTKIMSSYLLALVVSDYTNVTSAD---GTLIRIWARKKAIEDGHGDYALNITGPILKFFENYYNV 304

  Fly   274 PYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLE 338
            |||..|.||:.|||..:.:.|:.|||.|.|:..||....|:...|::.|:.:|.|.||.|..:|.
Zfish   305 PYPLSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWFGNLV 369

  Fly   339 NAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKSS 400
            ....:   ||:.|.:.|||....|..||:|...:|.:::....|...|:.:|::|:|    ||..
Zfish   370 TLKWWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLS----SKEE 430

  Fly   401 ------------DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEE 453
                        ||.:..|.|.:.|||...:....|:..|..||......::..:. ||..|| .
Zfish   431 DIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGED-LWDHLQ-T 493

  Fly   454 SDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQC---W 515
            :.|:......:.|..:||.|.:|.|:|::.|    :|....|:|..||.:|...:|:....   |
Zfish   494 AVNKTGTVLPLSVKVIMDRWVLQMGFPVVTV----NTTTGQVSQMHFLLDPESSLQRTSPFNYEW 554

  Fly   516 WVPLTFATAGI--DSFVSTLPSEWLTCQGRQTASPLILNEV-AQPDKWVVFNLRLATPCRITYDE 577
            .||:.:..:.:  ..|       ||.   .:||   :.|:: ....:||:.||.:....|:.||.
Zfish   555 IVPINWMKSKMVQSRF-------WLL---ERTA---VYNDMKTTGSEWVLLNLNITGYYRVNYDI 606

  Fly   578 RNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADT 642
            .||:.:.|.|: .|...|....|||::.|..|||.|.::...|||....:|..|.|::.||:|..
Zfish   607 GNWERLLNQLA-ENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALN 670

  Fly   643 YLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFK---RDGSAAENANITEL-MVIVLQLSCRTD 703
            .|::.:....||.:....:.:.:..:...|| .||   .|.|...:.:..:. .|..::.:|.|.
Zfish   671 NLDYFYLMFTQTEVYRLLQSYTKKQVTPLFD-YFKTITEDWSDVPSGHTDQYNQVNAIRFACSTG 734

  Fly   704 LESCADFALKEFAGLTLETNRIPV--DLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILL 766
            ::.|.:.....:.....:.|..|:  :|..|:||:||..|...:|.....::..:.:..::  |:
Zfish   735 VDECQNLTSSWYKQWMDQPNHNPIHPNLRSTVYCSAIATGGAEEWDFGWTMFKNAAIEADK--LM 797

  Fly   767 SAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSN 831
            |::||::....|.:.|........:.|.|...:...:|.||.|..:|.:::.:..:.:...||..
Zfish   798 SSLACAKNQTLLKRYLGYTLDPSMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTEYGVG 862

  Fly   832 TDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGF---EIAFRRILELGEDNISW 886
            :...|.|::.:.|..:||.||..|..| ::|...: ||   ..|..:.:|..:.||.|
Zfish   863 SFNFASLISGITKTFSTEAELEQLLKF-KSDNSEI-GFGSATAALEQAIEKTKANIKW 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	80/325 (25%)
		Peptidase_M1	25..392	CDD:279741	122/380 (32%)
		GluZincin	30..480	CDD:301352	145/477 (30%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	127/408 (31%)
		M1_APN_2	57..520	CDD:189008	145/475 (31%)
		ERAP1_C	590..911	CDD:288671	80/326 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040