DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43347 and CG10654

DIOPT Version :9

Sequence 1:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster
Sequence 2:	NP_001261767.1	Gene:	CG10654 / 39428	FlyBaseID:	FBgn0036294	Length:	412	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	88/455 - (19%)
Similarity:	154/455 - (33%)	Gaps:	130/455 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   935 CRECSIAHDHKLCPLRNACGNVTDAVDL--------GEWIERRNLEALAKLKA------------ 979
            ||.|.:     |...::||.|:....||        || ...|:|.....||:
  Fly    40 CRACLV-----LLGPQDACHNLDSEQDLASKYYGCTGE-DAVRDLPPQLVLKSICECCYQLVQKF 98

  Fly   980 -DAQRQAKRASGRQRHEDDDMEDMEDMDM-----------DMDESSQLSELETKPLITFAEASVP 1032
             |.||..  |...:..|    :.::|:|:           |:|..|:.:| .|.|   .|::..|
  Fly    99 HDFQRMC--AESLRNFE----KLLQDIDIGCHKLEDHTWHDLDTPSESNE-STNP---EAQSHAP 153

  Fly  1033 AEFELHNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYLLCC 1097
            .             :.|..|:.:|  :.|.:..|:..           |......||
  Fly   154 C-------------IAATQEIVSF--IWPQVCLPLAV-----------ILSRITLGA-------- 184

  Fly  1098 DNPNASNWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRN--GMELLYWSDDCNTMWRKKHTE 1160
                                      |::.:.|.:.....:.  |.|.|..|.......:::...
  Fly   185 --------------------------SLEEEVYVIEDESAKQDLGQEKLSISSKLLGARKRRGVR 223

  Fly  1161 KT-NCGGCNLKFEHPLYYRTHCSVFHDPSMSLTIRKYHCKVCGEPVLGKDNIMKHAAEKHDGKGA 1224
            .| .|..|:..|..|.....|... |:     .:|.|.|..|.:.....:.:..|..:.|:...|
  Fly   224 HTLECRICHRGFYKPSLLEAHMQQ-HE-----GLRPYTCVHCAKSYARANLLESHLRQMHNNADA 282

  Fly  1225 ----YQCQFCSKFF-----LRLNYLEMHRTYGCASNPNRSRPVCDFCGRKFCQPQKLKAHIKRMH 1280
                |.|..|:|.:     |:.:....|..|..:.:|: :|.:|:.||:.|.:...|..| |.:|
  Fly   283 ARIIYACPSCNKVYTANRSLKYHMRRTHERYHESESPD-ARHICEECGKCFARKAHLTRH-KMVH 345

  Fly  1281 SDMAEVLRDFQCKLCSKLLGSRAALQRHSKEVHSRNSTVVSCPRCQKLFQNRSNLKIHMLTHSGV 1345
            ..:..  |.:.|:.|.:...::..:..|....|...:.::.|.:|.::|||...|..|...|..:
  Fly   346 GSVEG--RRYCCECCDRRFYTKENMVDHLLRKHGNKNLLLRCRKCGRIFQNSVELNAHGRKHKAM 408

Fly 1346 1345
Fly 409 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	18/78 (23%)
		C2H2 Zn finger	1198..1219	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1227..1255	CDD:275368	7/32 (22%)
		C2H2 Zn finger	1259..1280	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1292..1313	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1322..1342	CDD:275368	7/19 (37%)
		zf-H2C2_2	1334..1361	CDD:290200	3/12 (25%)
		C2H2 Zn finger	1350..1373	CDD:275368
CG10654	NP_001261767.1	zf-AD	39..115	CDD:285071	20/86 (23%)
		C2H2 Zn finger	228..248	CDD:275368	5/20 (25%)
		C2H2 Zn finger	256..313	CDD:275368	11/56 (20%)
		C2H2 Zn finger	289..314	CDD:275368	5/24 (21%)
		zf-C2H2	323..345	CDD:278523	7/22 (32%)
		C2H2 Zn finger	325..345	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	3/20 (15%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100