DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43347 and CG1529

DIOPT Version :9

Sequence 1:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster
Sequence 2:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	91/440 - (20%)
Similarity:	162/440 - (36%)	Gaps:	127/440 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1227 CQFCSKFFLRLNYLE-----MHRTYGCASNPNRSRP-VCDFCGRKFCQPQKLKAHIKRMHSDMAE 1285
            |..|.|...:|.|||     :|:.|        |:| :|..|.:.|.:.::|::|::..|..:.:
  Fly   171 CDQCGKQVYKLPYLEAHIRSVHQGY--------SKPFLCRSCDKSFTRYEQLRSHMRNAHPQLEQ 227

  Fly  1286 V---LRDFQCKLCSKLLGSRAALQRHSKEVHSRNSTVVSCPRCQKLFQNRSNLKIHMLTHSGV-R 1346
            :   |||..|:||::...::.||..|.|....|...|  |..|......|:.|..|:.||:.. .
  Fly   228 LQQELRDLICELCNRQYSTKNALGEHLKRHAQRKEHV--CEHCGVAKVTRTELLTHLRTHNPTWE 290

  Fly  1347 PFKCAEPECNAAFTTKQCLQFHYKKVHNYTQE-QMPKIERSVAYTFDAYSGGMKVDFLGKQTATA 1410
            .|||  .:|...|..|..:..|.:.||...:. |....|:.    |..::..::.:.|      .
  Fly   291 RFKC--EQCPQLFRHKSAISRHVRVVHEGQRRFQCGHCEKK----FGTHASQVRHERL------H 343

  Fly  1411 TPASAASAQAQPRPNAAVVSPSSFTEQAPRRRRKSLEDQSSMLSGSLQSDAEFSDDNLFEAIKKS 1475
            |.::.:...|:..|.|.:..      |.|...|::||
  Fly   344 TESTGSGEAAEEWPFACIHC------QKPCVSRQTLE---------------------------- 374

  Fly  1476 GKSIKDLCRNEPNLSLLSSKISSIFGDKVPSATASLSASVSAVASSGARKRKRKKEPVVPAQQQL 1540
                         |.|...:                           |||..||:..
  Fly   375 -------------LHLRRHR---------------------------ARKTHRKRRE-------- 391

  Fly  1541 HLHQQQQQQQQ----QQQQSQHQQQHQQQHAQQLQHQQLQQQHAQQHQQQQHHLHQQHQQLHHDP 1601
            |..:.|:|:|:    |:|.::..||.|.:..::|:.:.|.:      :..::.:..|..|..::.
  Fly   392 HSRESQEQEQEHDRDQEQGAREAQQDQLRKGEKLRQRDLSR------ESHRNEVTMQTSQRPNEC 450

  Fly  1602 QQQHPQYHPHQLHAHALPHQQQQQQQQQQQQQQQLHGDPDDEEVENARLE 1651
            ||....|.|......|...:.:|:.....:.|.::  :.|.|..::||||
  Fly   451 QQGQESYDPEPDPLEASQCKLEQEDALDPEWQHKI--EQDAESQDSARLE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	14/46 (30%)
		C2H2 Zn finger	1198..1219	CDD:275368
		C2H2 Zn finger	1227..1255	CDD:275368	9/32 (28%)
		C2H2 Zn finger	1259..1280	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1292..1313	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1322..1342	CDD:275368	5/19 (26%)
		zf-H2C2_2	1334..1361	CDD:290200	9/27 (33%)
		C2H2 Zn finger	1350..1373	CDD:275368	5/22 (23%)
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071
		C2H2 Zn finger	171..192	CDD:275368	7/20 (35%)
		zf-C2H2_2	201..>257	CDD:289522	16/55 (29%)
		C2H2 Zn finger	201..222	CDD:275368	5/20 (25%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-C2H2_8	268..349	CDD:292531	20/92 (22%)
		C2H2 Zn finger	294..315	CDD:275368	5/22 (23%)
		C2H2 Zn finger	323..343	CDD:275368	3/29 (10%)
		C2H2 Zn finger	360..380	CDD:275368	7/66 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100