DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43347 and ztf-15

DIOPT Version :9

Sequence 1:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster
Sequence 2:	NP_492052.2	Gene:	ztf-15 / 172470	WormBaseID:	WBGene00011066	Length:	729	Species:	Caenorhabditis elegans

Alignment Length:	825	Identity:	145/825 - (17%)
Similarity:	266/825 - (32%)	Gaps:	284/825 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1009 MDESSQ---LSELETKPLITFAEASVPAEFELHNVEPNVTGVFARTEVR-AFTKLGPLIGQPVQT 1069
            |:||.|   |..:|.:  |......:|.|..|.:::    .:|....:| :.||     ..|..:
Worm     1 MEESDQTVLLPNVENE--IGSFYHDMPDEKLLRHIK----AIFDEASLRPSLTK-----NVPSTS 54

  Fly  1070 GEVREGSDMKWIFEMCEAGADKSYLLCCDNP------------------NASNWLRFVRPAPSY- 1115
            .:|.|..:...|.:......|:.||...:||                  ::.|.::::....:|
Worm    55 SQVTEELNKVEIRDPKHEMQDEQYLSIFENPSGVQYNQADGSFSWNNRFHSDNSVQYINVLNNYG 119

  Fly  1116 ---------------------EERNV---------NLVSIDRQAYFVSCRDLRNGMELLYWSDDC 1150
                                 |||..         ||.|.....|:..    |.|..::    :|
Worm   120 CEGADTLLNQSDSSDETDESIEERRTPRGNRQSRSNLTSKPSAKYWTK----RGGDPIV----NC 176

  Fly  1151 NTMWRKKHTEKTNCGGCNLKFEHPLYYRTHCSVFHDPSMSLTIRKYHCKVCGEPVLGKDNIMKHA 1215
                        :|..|..||.     ...|.:.|............|.:||:....:.:|..|.
Worm   177 ------------SCSICGSKFS-----TIRCLLDHRHQEHSLKDMMMCGLCGKEFSKRTHIYLHL 224

  Fly  1216 AEKHDGKGAYQCQFCSKFFLRLNYLEMHR---------------------------------TYG 1247
            ::::.   .|.|..|:..|....:||.||                                 .:|
Worm   225 SQEYK---VYHCDGCNTSFASKWHLEKHRCKENETIDDKKRRRTGRVNAEEIKVIKEEIQDEEFG 286

  Fly  1248 --CASNPNRSRP-------VCDFCGRKFCQPQKLKAHIKRMHSDMAEVLRDFQCKLCSKLLGSRA 1303
              ..||.|..:.       .|..||:|:.....|..| :....:..:.:::|:|.:|.:...|..
Worm   287 GVVLSNENHEKSKEDRFQFACVLCGKKYQHYHWLLKH-RTKCLETTDEIQEFKCNVCYRRYNSSF 350

  Fly  1304 ALQRHSKEVHSRNS-------TVVSCPRCQKLFQNRSNLKIHMLTHSGVRPFKCAEPECNAAFTT 1361
            ..:||.::.:|..:       ..:|||.|.|.:||......|          |...|:...|.:
Worm   351 WFERHMEKCNSSTALPPALLDQTISCPNCHKKYQNEYWFDYH----------KKHCPDITPALS- 404

  Fly  1362 KQCLQFHYKKVH---NYTQEQMPKIERSVAYTFDAYSGGMKV----DFLGKQTATATPASAASAQ 1419
                     .||   |..:::.|: |..::...|....|::.    |....:.|.||.:|::|:.
Worm   405 ---------DVHLDVNSLRDRRPR-EGEISVVPDVNLFGIEPEREDDNDDDEDADATISSSSSST 459

  Fly  1420 AQPRPNAAVVSPSSFTEQ------APRRRRKSLEDQSSMLS--------GSLQS-----DAEFSD 1465
            ..     .|..|.|...:      :....||.:...::||:        .:|.|     ..|:|
Worm   460 GN-----LVNIPCSICGKFCVGVASLLHHRKQIHGLTAMLTCGVCTKKFNTLSSIRRHMSMEYS- 518

  Fly  1466 DNLFEAIKKSGKSIKD---LCRNE---------------PNLSLLSSKISSIFGDKVPSATASLS 1512
              :|.. ::.|::..|   |.|:|               .|:|:|          |.|...|:.
Worm   519 --IFRC-QQCGRNCIDRTTLDRHECFKPYKIRDKRLFNIQNISVL----------KCPDCRATF- 569

  Fly  1513 ASVSAVASSGARKRKRKKEPVVPAQQQLHLHQQQQQ-----QQQQQQQSQHQQQHQQQHAQQLQH 1572
            |:::.::.                      |::..|     ...||..|...:||   |......
Worm   570 ANLNVLSE----------------------HRKTCQYGNVFDNIQQPGSSSLRQH---HRSDTNG 609

  Fly  1573 QQLQQQ--------------------HAQQHQQQQ--HHLHQQH-QQLH--HDPQQQHPQYHPHQ 1612
            ..||::                    ||..|..|.  .|.|:.| :::.  ::..:..|.|  ..
Worm   610 AALQRKITSRVRLDSNTPEKWTCRDCHASFHNLQALCSHRHESHGKEMFQCNNCSETLPNY--RA 672

  Fly  1613 LHAHALPHQQQQQQQQQQQQQQQLHGDPDDEEVENARLEQVRRKQ 1657
            ||.|.:.|.:..:...:...::....|.:.:.::|.::..|...:
Worm   673 LHDHNMMHCRNNRSTNETTTRRYSEEDINYDYMDNVQIFVVEESE 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	21/111 (19%)
		C2H2 Zn finger	1198..1219	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1227..1255	CDD:275368	11/62 (18%)
		C2H2 Zn finger	1259..1280	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1292..1313	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1322..1342	CDD:275368	7/19 (37%)
		zf-H2C2_2	1334..1361	CDD:290200	4/26 (15%)
		C2H2 Zn finger	1350..1373	CDD:275368	2/22 (9%)
ztf-15	NP_492052.2	C2H2 Zn finger	178..199	CDD:275368	6/25 (24%)
		C2H2 Zn finger	207..223	CDD:275368	4/15 (27%)
		C2H2 Zn finger	233..250	CDD:275368	5/16 (31%)
		SFP1	<337..395	CDD:227516	16/67 (24%)
		C2H2 Zn finger	467..488	CDD:275368	3/20 (15%)
		C2H2 Zn finger	496..514	CDD:275368	2/17 (12%)
		C2H2 Zn finger	522..538	CDD:275368	3/16 (19%)
		C2H2 Zn finger	562..581	CDD:275368	4/41 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100