DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and Drgx

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_001097075.2 Gene:Drgx / 5740176 FlyBaseID:FBgn0085369 Length:587 Species:Drosophila melanogaster


Alignment Length:348 Identity:83/348 - (23%)
Similarity:136/348 - (39%) Gaps:87/348 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    54 QTIPSLNP-GSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAA 117
            |..|:|:| |.||       |:               |...:||:              ||....
  Fly     5 QCPPALHPCGPHP-------PR---------------LPTLDYPF--------------AATHPY 33

Human   118 TAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDL 182
            |:.:..||.  |.|:.....     .||.||.:|..||.|||..|....|.....|.::|..::|
  Fly    34 TSYSYHPAI--HDETFVRRK-----QRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINL 91

Human   183 TERQVKVWFQNRRMKHKRQTQCK------ENQNSEGKCKSLEDSE--------KVEEDEEEKTLF 233
            ||.:|:|||||||.|.::..:.|      ||..|......|.||.        ::::|.::....
  Fly    92 TEARVQVWFQNRRAKWRKAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPR 156

Human   234 EQALS--VSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNE---------KNLKHF 287
            :::.|  .:|.:.::..::   ::.|..::|.|......|....||:||:         ::|...
  Fly   157 QRSHSPLANGQMEQQHSHS---HSHSHSRSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSI 218

Human   288 QHQSPTVPNCLSTMGQNC----GAG---------LNNDSPEALEVP-SLQDFSVFSTDSCLQLSD 338
            ...||: |:.:....::.    |.|         .|.|||..:..| ||...|..:..|....|.
  Fly   219 SAGSPS-PSGMHREREHTPLVGGGGQGPSSPSNSRNTDSPIEVGGPMSLTTGSRMAASSNNSASS 282

Human   339 AVSPSLPGSLDSPVDISADSLDF 361
            ..:|:.|.:...|...:|.:..|
  Fly   283 TPTPTTPHAPQMPHSSAAAAAAF 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 9/39 (23%)
Antp-type hexapeptide 94..99 2/4 (50%)
Homeodomain 144..200 CDD:459649 26/55 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 8/44 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 6/21 (29%)
DrgxNP_001097075.2 Homeodomain 53..109 CDD:459649 26/55 (47%)
OAR 428..446 CDD:461067
Blue background indicates that the domain is not in the aligned region.

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