DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and E5

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_524825.1 Gene:E5 / 45396 FlyBaseID:FBgn0008646 Length:524 Species:Drosophila melanogaster


Alignment Length:336 Identity:93/336 - (27%)
Similarity:134/336 - (39%) Gaps:106/336 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    14 SQPSLAECLTSFPP-VADTFQSSSIKTSTLSH---------STLIPP----PFEQTIPSLNPGSH 64
            |||         || :|..||.:    :.|:|         ...:||    |.....|.|.||..
  Fly   190 SQP---------PPFLAAQFQMA----AALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQI 241

Human    65 PRHGAGGRPKPSPAGSRGSPVPAG----ALQP-------PEYPWMKEKKAAKKTALLPAAAAAAT 118
            |.....|.|.|      |.|.|.|    ...|       |.|||:    .::...:.|..     
  Fly   242 PLGIFPGGPHP------GHPPPHGHHPFGSAPHLIRDSYPLYPWL----LSRHGRIFPRF----- 291

Human   119 AAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLT 183
                 |.....:...:        .:|:|||::.||||:||..|..|.|:....|.::|..|.||
  Fly   292 -----PGNFLFQPFRK--------PKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLT 343

Human   184 ERQVKVWFQNRRMKHKRQTQ-------CKENQNS----------------EGKCKSLEDSE---- 221
            |.||||||||||.||||..|       .|.|:.|                :|...|.||:|    
  Fly   344 ETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPED 408

Human   222 --KVEEDEEEKTLFEQALSVSGALLEREGY-----TFQQN-ALSQQQAPNGHNGDSQSFPVSPLT 278
              ::|||:|::.:   .:...|:.::.|.:     .|||. |..|||....:.|::.:  :||..
  Fly   409 EDEIEEDDEDEVI---DMDDYGSEMDAEEHQRLREQFQQQLAQHQQQFMQQNAGEAAT--LSPQQ 468

Human   279 SNEKNLKHFQH 289
            .::...:|.||
  Fly   469 QHQLLQQHQQH 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 18/74 (24%)
Antp-type hexapeptide 94..99 3/4 (75%)
Homeodomain 144..200 CDD:459649 31/55 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 15/59 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 6/21 (29%)
E5NP_524825.1 Homeodomain 304..360 CDD:459649 31/55 (56%)

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