DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and lbe

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_524435.2 Gene:lbe / 42542 FlyBaseID:FBgn0011278 Length:479 Species:Drosophila melanogaster


Alignment Length:339 Identity:77/339 - (22%)
Similarity:113/339 - (33%) Gaps:149/339 - (43%)


- Green bases have known domain annotations that are detailed below.


Human    23 TSFPPVA--------------DTFQSSSIKTSTLSHS------TLIPPPFEQTIPSLNPGSHPRH 67
            |..||.|              :..:|.|| ...|.||      ::.|||....:..  |.|.|..
  Fly   108 TPSPPSAVPEPQTNQTTKSAIEGVKSFSI-ADILGHSEKQREESVSPPPNANLLAP--PASRPIA 169

Human    68 GAGGRPKP-------SPAGSRGSPVPAGAL-QP---------PEYPWMK------EKKAA----- 104
            .:||..:|       .||.:....:|:|.: :|         |..|::.      |::.|     
  Fly   170 PSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHR 234

Human   105 -------------KKTALLPAAAAA---------ATAAATGPA-CLS------------------ 128
                         :...:.||..|:         .::::.|.. |.|                  
  Fly   235 QLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEE 299

Human   129 --HKESLEIADGSGGGS-------------------------------------RRLRTAYTNTQ 154
              .|:|.|...|||..:                                     |:.|||:||.|
  Fly   300 AQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQ 364

Human   155 LLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLED 219
            :.||||.|.:.|||....|.||||.|.|:..||..||||||.|.||                  |
  Fly   365 IFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKR------------------D 411

Human   220 SEKVEEDEEEKTLF 233
            .|::::|.:...:|
  Fly   412 IEELKKDFDSVKVF 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 17/73 (23%)
Antp-type hexapeptide 94..99 1/4 (25%)
Homeodomain 144..200 CDD:459649 31/55 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279
lbeNP_524435.2 Homeodomain 354..410 CDD:459649 31/55 (56%)
Blue background indicates that the domain is not in the aligned region.

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