DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and lbl

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_001262805.1 Gene:lbl / 42541 FlyBaseID:FBgn0008651 Length:410 Species:Drosophila melanogaster


Alignment Length:349 Identity:84/349 - (24%)
Similarity:119/349 - (34%) Gaps:117/349 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     9 IGFINSQ---PSLAECLTSFPPVA-DTFQSSSIKTSTLSHSTLIPPPFEQTIP------------ 57
            :..||.:   |.:..|.   ||.| .||.|.:     |.||      :||.:.            
  Fly    90 LALINERLQIPLVPNCP---PPAALHTFLSPA-----LLHS------YEQRLAWDYQRQLQEHFQ 140

Human    58 ---------SLNPGSHPRHGAGGRPKPSPAGSRG-----SPVPAGALQ----------PPEYPWM 98
                     :|||................:.|.|     ||..|..::          |.:.|..
  Fly   141 AQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEE 205

Human    99 KEKKAAKKTALLPAAAAAATAAAT-----GPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLEL 158
            :.|.|:|.:...|..|....:...     .||.|    ::.....:....|:.|||:||.|:.||
  Fly   206 QPKGASKSSGDTPLDALFQLSTKNFDEEQDPATL----NIFATRSNPKKKRKSRTAFTNQQIFEL 266

Human   159 EKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR-------QTQCKE---------- 206
            ||.|.:.|||....|.|||..|.|:..||..||||||.|.||       ..||::          
  Fly   267 EKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKIPDQSADPNR 331

Human   207 ----------------NQNSEGKCKSLEDSEKVEEDEEEK-----------TLFEQALSVSGALL 244
                            :..|.|..:.: |.::..|.|::|           ||...:   .|.||
  Fly   332 SHHNHPHYHQQHQHYAHMQSIGSDRDM-DKDRCREKEKDKDKEELRMLKLMTLMRYS---DGKLL 392

Human   245 EREGYTFQQNALSQQQAPNGHNGD 268
                  :||...|....|:..|.|
  Fly   393 ------YQQPPASYLPIPHRQNAD 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 13/86 (15%)
Antp-type hexapeptide 94..99 1/4 (25%)
Homeodomain 144..200 CDD:459649 30/55 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 9/63 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 4/12 (33%)
lblNP_001262805.1 COG5576 206..332 CDD:227863 42/129 (33%)
Homeodomain 252..308 CDD:459649 30/55 (55%)

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