DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and HHEX

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_650938.2 Gene:HHEX / 42495 FlyBaseID:FBgn0038852 Length:323 Species:Drosophila melanogaster


Alignment Length:242 Identity:61/242 - (25%)
Similarity:93/242 - (38%) Gaps:67/242 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    34 SSSIKTSTLSHSTLIPPP---FEQTIPSLNPGSHPRHGAGGRPKPS---PAGSRGSPVPAGALQP 92
            |:.:..::|..:.:.|.|   |.|.:..|            :..||   |.....:...|.|:||
  Fly    96 SAVLAPTSLRFNPIYPDPASLFYQQVLQL------------QKNPSLFMPHFQAAAVAAAAAVQP 148

Human    93 PEY-----PWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTN 152
            ..|     |:..:.:....    ||:||||......||...:..:..:.  ..||..|    :|:
  Fly   149 TAYCDQYSPFTMDCEGFPN----PASAAAALYCNAYPAASFYMSNFGVK--RKGGQIR----FTS 203

Human   153 TQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEG----- 212
            .|...||..|..:|||....|..:|..|.||:||||.||||||.|.:|....|.:.:::|     
  Fly   204 QQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGA 268

Human   213 ----------------------KCKSLED-------SEKVEEDEEEK 230
                                  :|....|       ||..|:|:|::
  Fly   269 AVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDEDE 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 12/56 (21%)
Antp-type hexapeptide 94..99 2/9 (22%)
Homeodomain 144..200 CDD:459649 25/55 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 9/64 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279
HHEXNP_650938.2 Homeodomain 200..251 CDD:459649 25/54 (46%)
Blue background indicates that the domain is not in the aligned region.

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