DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and abd-A

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_732176.1 Gene:abd-A / 42037 FlyBaseID:FBgn0000014 Length:590 Species:Drosophila melanogaster


Alignment Length:318 Identity:93/318 - (29%)
Similarity:126/318 - (39%) Gaps:86/318 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    28 VADTFQSSSIKTST-------LSHSTLIPPPFEQT------IPSL-----NPGSHPRHGAGGRPK 74
            |.:::||.|:..|.       ..|:|.........      :.||     .|.|....||||   
  Fly   296 VMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNACTQPASGVMPGAGG--- 357

Human    75 PSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGS 139
               ||.      ||....|.||||                 ..|.....|.     |.:...|.:
  Fly   358 ---AGG------AGIADLPRYPWM-----------------TLTDWMGSPF-----ERVVCGDFN 391

Human   140 GGGS---RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 201
            |...   ||.|..||..|.||||||||||.||.|.||:|||..|.|||||:|:||||||||.|::
  Fly   392 GPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKE 456

Human   202 TQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFE-QALSVSGALLEREGYTFQQNALSQQQAPNGH 265
            .:..:..|.:.: :..|:.||::..|..|:..: :.:.......:::....||....|||.|..|
  Fly   457 LRAVKEINEQAR-RDREEQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQQQQQHQQQQQQPQDH 520

Human   266 NGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQN---------CGAGLNNDSP 314
            :        |.:..|..:|.|            |.:|||         .|.|:....|
  Fly   521 H--------SIIAHNPGHLHH------------SVVGQNDLKLGLGMGVGVGVGGIGP 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 14/61 (23%)
Antp-type hexapeptide 94..99 3/4 (75%)
Homeodomain 144..200 CDD:459649 39/55 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 6/21 (29%)
abd-ANP_732176.1 Homeodomain 399..455 CDD:459649 39/55 (71%)
Abdominal-A 456..478 CDD:403567 4/22 (18%)

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