DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HOXA2 and Ubx

DIOPT Version :9

Sequence 1:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster

Alignment Length:	230	Identity:	70/230 - (30%)
Similarity:	93/230 - (40%)	Gaps:	57/230 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    60 NPGSHPRHGAGGRPKPSPAGSRGSPVPAG-------------------------------ALQPP 93
            :|.||....|||....|........|.:|                               |....
  Fly   174 SPVSHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHT 238

Human    94 EYPWM-------KEKKAAKKTALLPAAAAAATAAATGPACLSHKESLE---IAD--GSGGGSRRL 146
            .||||       ::...:|..:.|......:|....     .:.|||.   :.|  |:.|..||.
  Fly   239 FYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGK-----RYSESLAGSLLPDWLGTNGLRRRG 298

Human   147 RTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSE 211
            |..||..|.||||||||.|.||.|.||:|:|..|.|||||:|:||||||||.|::.|.
  Fly   299 RQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQA------- 356

Human   212 GKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLER 246
              .|.|.:.||..:.::.......|.:|.|..|::
  Fly   357 --IKELNEQEKQAQAQKAAAAAAAAAAVQGGHLDQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		10/63 (16%)
		Antp-type hexapeptide	94..99		4/11 (36%)
		Homeobox	147..200	CDD:395001	35/52 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810