DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA2 and Antp

DIOPT Version :9

Sequence 1:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	66/194 - (34%)
Similarity:	78/194 - (40%)	Gaps:	70/194 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    26 PPVADTFQSSSIKTSTLSHSTLIPP------PFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSP 84
            |||....|.       :.|....||      |.:.|.||.||.|.               |.|.|
  Fly   238 PPVGAPPQG-------MMHQGQGPPQMHQGHPGQHTPPSQNPNSQ---------------SSGMP 280

Human    85 VPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTA 149
            .|.       ||||:.:..                     .|...|              |.|..
  Fly   281 SPL-------YPWMRSQFG---------------------KCQERK--------------RGRQT 303

Human   150 YTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGK 213
            ||..|.||||||||||:||.|.||:|||..|.|||||:|:||||||||.|::.:.|....|.|:
  Fly   304 YTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGEPGSGGE 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		14/56 (25%)
		Antp-type hexapeptide	94..99		3/4 (75%)
		Homeobox	147..200	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	27/131 (21%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	37/52 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810