DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and ftz

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_477498.1 Gene:ftz / 40834 FlyBaseID:FBgn0001077 Length:410 Species:Drosophila melanogaster


Alignment Length:312 Identity:86/312 - (27%)
Similarity:122/312 - (39%) Gaps:74/312 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    12 INSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIP-----PPFEQTIPSLNPGSHPRHGAGG 71
            :...|:::..:|:.|  |.::....:...|.|.|..:.     .|..||....|         |.
  Fly   134 VKKAPAVSTKVTASP--APSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKN---------GD 187

Human    72 RPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKT---ALLPAAAAAATAAATGPACLSHKESL 133
            ...|.|......|...|...||:.|..|...|..:.   .::.|...|      |....||.|..
  Fly   188 FATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGA------GDFNWSHIEET 246

Human   134 EIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKH 198
            ..:|..  .|:|.|..||..|.||||||||||:|:.|.||::||..|.|:|||:|:||||||||.
  Fly   247 LASDCK--DSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKS 309

Human   199 KRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPN 263
            |:                            ::|| :.:....||     |||..   |...:|.:
  Fly   310 KK----------------------------DRTL-DSSPEHCGA-----GYTAM---LPPLEATS 337

Human   264 GHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPE 315
            .....:.|.|| |:         :.|...|......:...:.|.||.||.|:
  Fly   338 TATTGAPSVPV-PM---------YHHHQTTAAYPAYSHSHSHGYGLLNDYPQ 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 11/55 (20%)
Antp-type hexapeptide 94..99 1/4 (25%)
Homeodomain 144..200 CDD:459649 35/55 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 1/30 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 5/21 (24%)
ftzNP_477498.1 FTZ 1..248 CDD:397787 27/130 (21%)
Homeodomain 255..311 CDD:459649 35/55 (64%)
KLF1_2_4_N <321..404 CDD:425360 19/77 (25%)

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